A5101488632- Calpain Protease Function and Regulation
- Cardiomyopathy and Myosin Studies
- Parathyroid Disorders and Treatments
- Hepatitis C virus research
- RNA regulation and disease
- Liver Disease Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Neurological and metabolic disorders
- Monoclonal and Polyclonal Antibodies Research
- Dialysis and Renal Disease Management
- Hepatitis B Virus Studies
- Herpesvirus Infections and Treatments
- Chronic Lymphocytic Leukemia Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Tracheal and airway disorders
- Meat and Animal Product Quality
- Sarcoidosis and Beryllium Toxicity Research
- Foreign Body Medical Cases
- Topic Modeling
- Systemic Lupus Erythematosus Research
- NF-κB Signaling Pathways
- Soft tissue tumor case studies
- Neurological disorders and treatments
- Colorectal Cancer Treatments and Studies
- Tendon Structure and Treatment
Central University Hospital of Asturias
2023
Universidad Politécnica de Madrid
2022
Shenzhen University
2022
University of South Dakota
2022
Università Campus Bio-Medico
2022
University of Aveiro
2022
Karlstad University
2022
Cleveland Clinic Florida
2021
Hospital General Universitario de Ciudad Real
2018
Complejo Hospitalario Universitario de Santiago
2006-2015
Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation infertility, hyperandrogenemia, and frequently insulin resistance. This study investigated whether polymorphisms in the CAPN10 gene are related with PCOS etiology. The allelic frequencies genotypes of UCSNP-44, 43, 19, 63 were determined 55 well women polycystic ovaries 93 unrelated healthy controls using spectrofluorimetric analyses real-time PCR. Our data indicate that UCSNP-44 allele associated Spanish population (P...
BackgroundDifficult facemask ventilation is perilous in children whose tracheas are difficult to intubate. We hypothesised that certain physical characteristics and anaesthetic factors associated with mask paediatric patients who also had tracheal intubation.MethodsWe queried a multicentre registry for experienced "difficult" or "impossible" ventilation. Patient case known before attempt were included consideration this regularised multivariable regression analysis. Incidence of...
BackgroundThe Paediatric Difficult Intubation Collaborative identified multiple attempts and persistence with direct laryngoscopy as risk factors for complications in children difficult tracheal intubations subsequently engaged initiatives to reduce repeated children. We hypothesised these efforts would lead fewer attempts, decrease complications.MethodsPaediatric patients less than 18 years of age were enrolled the Registry. define those whom (1) an attending or consultant obtained a...
Abstract Recently, several research groups have evaluated CAPN10 gene in polycystic ovarian syndrome (PCOS) patients and other phenotypes, including hirsutism or intermediate phenotypes of PCOS. Molecular genetic analysis indicates that different alleles may play a role PCOS susceptibility could be associated with idiopathic hirsutism. However, these observations are not exempt from controversy, because independent studies cannot replicate preliminary findings. We present haplotype-phenotype...
Cardiovascular disease is the leading cause of morbidity and mortality in industrialized world. Familial aggregation cardiovascular risk factors a frequent finding, but genetic affecting its presentation are still poorly understood. The calpain 10 gene (CAPN10) has been associated with type 2 diabetes (T2DM), complex metabolic disorder increased disease. Moreover, CAPN10 presence syndrome (MS) T2DM polycystic ovary (PCOS). In this work, we have analysed whether polymorphisms UCSNP44, -43,...
Genes implicated in common complex disorders such as obesity, type 2 diabetes mellitus (T2DM) or cardiovascular diseases are not disease specific, since clinically related also share genetic components. Cysteine protease Calpain 10 (CAPN10) has been associated with T2DM, hypertension, hypercholesterolemia, increased body mass index (BMI) and polycystic ovary syndrome (PCOS), a reproductive disorder of women which isunlin resistance seems to play pathogenic role. The calpain 5 gene (CAPN5)...
Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation infertility, hyperandrogenemia, and frequently insulin resistance. This study investigated whether polymorphisms in the CAPN10 gene are related with PCOS etiology. The allelic frequencies genotypes of UCSNP-44, 43, 19, 63 were determined 55 well women polycystic ovaries 93 unrelated healthy controls using spectrofluorimetric analyses real-time PCR. Our data indicate that UCSNP-44 allele associated Spanish population (P...
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. The aim the present study was to investigate role CALPAIN-5 (CAPN5) gene PCOS susceptibility. METHODS: We analysed four intronic polymorphisms CAPN5 148 well-characterized with and 606 unrelated controls. performed case-control an intracohort analysis clinical characteristics associated PCOS. RESULTS: Analysis haplotypes distribution between population compared controls showed strong...
The administration of a cholesterol‐lowering drug, 4,4‐(isopropylidenedithio) bis(2,6‐di‐tbutylphenol), probucol (DH‐581) at dosage 1,000 mg. per day for 6 months, usually did not affect other serum solutes, enzymes, hepatic indices, tests thyroid function, plasma 11(OH)‐corticosferoids (including diurnal variation, dexamethasone suppression, and ACTH stimulation effects), urinary creatinine, creatinine clearance, 17‐ketosteroids, Porter‐Silber chromogens, 11‐desoxycortisol metabolites, the...
Intravenous tolbutamide evoked an exaggerated hyperinsulinemia in persons with mild glucose intolerance, i.e. those equivocal Glucose Tolerance Sums or so-called chemical latent diabetes. The tolbutamide-induced was greater who were older and overweight. Such hyperinsulinemic responses association this limited degree of intolerance also present the younger members non-overweight group.
Lung cancer is the leading cause of death. More than 236,740 new cases lung patients are expected in 2022, with an estimation more 130,180 deaths. Improving survival rates or patient's quality life partially covered by a common element: treatments. Cancer treatments well known for toxic outcomes and secondary effects on patients. These toxicities different health problems that impact life. Reducing without decline positive effect important goal aims to be pursued from clinical perspective....
We analyzed the influence of 6 and 24 h treatment with fibric acid derivatives bezafibrate (10 μg/ml), gemfibrozil (23 fenofibrate (30 (μg/ml) on α-actinin, troponin-T, tropomyosin proteins in cytoplasmic cytoskeletal fractions cultured chick myocardiocyte s. The findings sodium dodecyl sul-fate-gel electrophoresis immunoblotting showed that all three drugs modified cellular subcellular protein levels different ways: produced most significant alterations both fractions, modifying troponin T,...