A5043937732- Supramolecular Self-Assembly in Materials
- Polydiacetylene-based materials and applications
- Antimicrobial Peptides and Activities
- Luminescence and Fluorescent Materials
- 2D Materials and Applications
- Electrospun Nanofibers in Biomedical Applications
- Chemical Synthesis and Analysis
- Advanced Sensor and Energy Harvesting Materials
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Conducting polymers and applications
- Cephalopods and Marine Biology
- Diatoms and Algae Research
- Silk-based biomaterials and applications
- Photochromic and Fluorescence Chemistry
- Neuroscience and Neural Engineering
- Wound Healing and Treatments
- Planarian Biology and Electrostimulation
- Biomimetic flight and propulsion mechanisms
- Microfluidic and Bio-sensing Technologies
- Micro and Nano Robotics
- Photoreceptor and optogenetics research
Harvard University
2018-2025
University of California, Irvine
2021-2024
Samueli Institute
2021-2024
Physical Sciences (United States)
2023-2024
Irvine University
2024
UC Irvine Health
2023
Johns Hopkins University
2014-2019
Inspire
2019
Harvard University Press
2019
University of Baltimore
2014-2015
Biohybrid systems have been developed to better understand the design principles and coordination mechanisms of biological systems. We consider whether two functional regulatory features heart-mechanoelectrical signaling automaticity-could be transferred a synthetic analog another fluid transport system: swimming fish. By leveraging cardiac mechanoelectrical signaling, we recreated reciprocal contraction relaxation in muscular bilayer construct where each occurs automatically as response...
Helical alignments within the heart's musculature have been speculated to be important in achieving physiological pumping efficiencies. Testing this possibility is difficult, however, because it challenging reproduce fine spatial features and complex structures of using current techniques. Here we report focused rotary jet spinning (FRJS), an additive manufacturing approach that enables rapid fabrication micro/nanofiber scaffolds with programmable three-dimensional geometries. Seeding these...
We report a peptide-based multichromophoric hydrogelator system, wherein π-electron units with different inherent spectral energies are spatially controlled within peptidic 1-D nanostructures to create localized energy gradients in aqueous environments. This is accomplished by mixing π-conjugated peptides prior initiating self-assembly through solution acidification. can vary the kinetics of assembly and degree self-sorting choice trigger, which changes The hydrolysis glucono-δ-lactone (GdL)...
Endothelial extracellular vesicles containing cardioprotective proteins rescue engineered human cardiac tissue in an ischemia-reperfusion injury model.
Engineering bioscaffolds for improved cutaneous tissue regeneration remains a healthcare challenge because of the increasing number patients suffering from acute and chronic wounds. To help address this problem, we propose to utilize alfalfa, an ancient medicinal plant that contains antibacterial/oxygenating chlorophylls bioactive phytoestrogens, as building block regenerative wound dressings. Alfalfa carries genistein, which is major phytoestrogen known accelerate skin repair. The scaffolds...
Steady-state and time-resolved photophysical measurements demonstrate energy transfer within π-conjugated peptide nanostructures composed of oligo-(
π-Conjugated peptide materials are attractive for bioelectronics due to their unique photophysical characteristics, biofunctional interfaces, and processability under aqueous conditions. In order be relevant electrical applications, these types of must able support the passage current transmission applied voltages. Presented herein is an investigation both voltage activities one-dimensional π-conjugated nanostructures. Observations nanostructures as semiconducting gate layers in organic...
An investigation of how systematic variation peptide sequence influences the nanoscale and bulk properties 1D-nanostructure forming peptide–π–peptide hydrogelators is reported herein.
In biomimetic design, researchers recreate existing biological structures to form functional devices. For biohybrid robotic swimmers assembled with tissue engineering, this is problematic because most devices operate at different length scales than their naturally occurring counterparts, resulting in reduced performance. To overcome these challenges, here, we demonstrate how machine learning–directed optimization (ML-DO) can be used inform the design of a robot, outperforming other nonlinear...
This work presents a strategy for generating composite hydrogels bearing photoconductive conduits held by supramolecular interactions and are compatible with digital light processing (DLP) printing. Conductive polymers typically processed...
The tunability of chromatic phases adapted by chromogenic polymers such as polydiacetylene (PDA) is key to their utility for robust sensing applications. Here, we investigated the influence charged peptide interactions on structure-dependent thermochromicity amphiphilic PDAs. Solid-state NMR and circular dichroism analyses show that our oppositely peptide-PDA samples have distinct degrees structural order, with coassembled sample being in between β-sheet-like positive relatively disordered...
The conduction efficiency of ions in excitable tissues and charged species organic conjugated materials both benefit from having ordered domains anisotropic pathways. In this study, a photocurrent-generating cardiac biointerface is presented, particularly for investigating the sensitivity cardiomyocytes to geometrically comply biomacromolecular cues differentially assembled on conductive nanogrooved substrate. Through polymeric surface-templated approach, photoconductive substrates with...
The deployment of organic molecules in high-performance devices strongly relies on the formation well-ordered domains, which is often complicated by dynamic and sensitive nature supramolecular interactions. Here, we engineered assembly water-processable, optoelectronic π-conjugated peptides into well-defined organic-inorganic heterointerfaced assemblies leveraging long-range anisotropic ordering 1D van der Waals (vdW) crystals composed subnanometer-thick transition metal sulfide chains (MS 3...
Advances in supramolecular assembly have enabled the design and synthesis of functional materials with well-defined structures across multiple length scales. Biopolymer-synthetic hybrid can assemble into a broad range structural diversity through precisely controlled noncovalent interactions between subunits. Despite recent progress, there is need to understand mechanisms underlying biohybrid/synthetic molecular building blocks, which ultimately control emergent properties hierarchical...
This photophysical study characterizes the generality of intermolecular electronic interactions present within nanomaterials derived from self-assembling oligopeptides with embedded π-conjugated oligophenylenevinylene (OPV) subunits stilbene and distyrylbenzene that in principle two distinct β-sheet motifs. Two different synthetic approaches led to upon self-assembly are expected self-assemble into multimeric aggregates stabilized by β-sheet-like secondary structures. The target molecules...
Supramolecular assembly is a powerful method that can be used to generate materials with well-defined structures across multiple length scales. assemblies consisting of biopolymer-synthetic polymer subunits are specifically known exhibit exceptional structural and functional diversity as well programmable control noncovalent interactions through hydrogen bonding in biopolymer subunits. Despite recent progress, there need quantitatively understand under nonequilibrium conditions. In this...
Abstract Peptides naturally have stimuli‐adaptive structural conformations that are advantageous for endowing synthetic materials with dynamic functionalities. Here, we report a carbodiimide‐based approach, combined electrostatic modulation, to instruct π‐conjugated peptides self‐assemble and be responsive thermal disassembly cues upon consumption of the assembly trigger. Quaterthiophene‐functionalized utilized as model system herein study formation nanostructures at non‐equilibrium states....
Precision control via molecular structure over adaptive conjugated polymer properties in aqueous environments is critical for realizing their biomedical applications. Here, we unravel the dependence of amphiphilic peptide-polydiacetylene (PDA) conjugate on characteristic steric and hydrophobic contributions within peptide segments that serve as a biomimetic template diacetylene polymerization water. We investigated functional impacts volume polarity changes brought by dipeptide substitution...
Self-assembling peptides are extensively exploited as bioactive materials in applications such regenerative medicine and drug delivery despite the fact that their relatively weak noncovalent interactions often render them susceptible to mechanical destruction solvent erosion. Herein, we describe how covalent cross-linking enhances stability of self-assembling π-conjugated peptide hydrogels. We designed short peptide-chromophore-peptide sequences displaying different reactive functional...