The conduction efficiency of ions in excitable tissues and charged species organic conjugated materials both benefit from having ordered domains anisotropic pathways. In this study, a photocurrent-generating cardiac biointerface is presented, particularly for investigating the sensitivity cardiomyocytes to geometrically comply biomacromolecular cues differentially assembled on conductive nanogrooved substrate. Through polymeric surface-templated approach, photoconductive substrates with...

This work presents a strategy for generating composite hydrogels bearing photoconductive conduits held by supramolecular interactions and are compatible with digital light processing (DLP) printing. Conductive polymers typically processed...

The deployment of organic molecules in high-performance devices strongly relies on the formation well-ordered domains, which is often complicated by dynamic and sensitive nature supramolecular interactions. Here, we engineered assembly water-processable, optoelectronic π-conjugated peptides into well-defined organic-inorganic heterointerfaced assemblies leveraging long-range anisotropic ordering 1D van der Waals (vdW) crystals composed subnanometer-thick transition metal sulfide chains (MS 3...

A NAD(P)H-dependent enoate reductase (OYE2p) from Saccharomyces cerevisiae YJM1341 was discovered by genome data mining for asymmetric reduction of (E/Z)-citral to (R)-citronellal with high enantioselectivity. This enzyme heterologously expressed in E. coli and characterized its biocatalytic properties. OYE2p identified activities toward a diverse range ɑ,β-unsaturated compounds bearing conjugated aldehyde, ketone, imide, carboxylic acid ester. showed the highest specific activity at 40 °C...

Oil spills have huge and immediate economically, socially, environmentally adverse impacts. Current methods to remediate oil do not provide a sustainable solution, in terms of cost, ease deployment, further impact on the environment. Here we report an spill remediation solution form oleophilic, hydrophobic, magnetic (OHM) sponge that is economical, efficient, ecofriendly; thereby promising potentially industry-adaptable approach. The OHM can only selectively remove from oil/water interface...

The tunability of chromatic phases adapted by chromogenic polymers such as polydiacetylene (PDA) is key to their utility for robust sensing applications. Here, we investigated the influence charged peptide interactions on structure-dependent thermochromicity amphiphilic PDAs. Solid-state NMR and circular dichroism analyses show that our oppositely peptide-PDA samples have distinct degrees structural order, with coassembled sample being in between β-sheet-like positive relatively disordered...

Abstract Peptides naturally have stimuli‐adaptive structural conformations that are advantageous for endowing synthetic materials with dynamic functionalities. Here, we report a carbodiimide‐based approach, combined electrostatic modulation, to instruct π‐conjugated peptides self‐assemble and be responsive thermal disassembly cues upon consumption of the assembly trigger. Quaterthiophene‐functionalized utilized as model system herein study formation nanostructures at non‐equilibrium states....

Precision control via molecular structure over adaptive conjugated polymer properties in aqueous environments is critical for realizing their biomedical applications. Here, we unravel the dependence of amphiphilic peptide-polydiacetylene (PDA) conjugate on characteristic steric and hydrophobic contributions within peptide segments that serve as a biomimetic template diacetylene polymerization water. We investigated functional impacts volume polarity changes brought by dipeptide substitution...

This study reported an attractive engineered carbonyl reductase from<italic>Gluconobacter oxydans</italic>through a structure-guided rational design to catalyze the synthesis of high concentration (<italic>R</italic>)-HPBE.

Abstract This work investigates the influence of dielectrophoretic forces on structural features and resulting aggregates a chromogenic model system, peptide‐diacetylene (D 3 GV‐DA) amphiphiles. Here, we systematically investigate how non‐uniform electric fields impact (i) peptide‐directed supramolecular assembly stage (ii) topochemical photopolymerization polydiacetylenes (PDAs) in quadrupole‐based dielectrophoresis (DEP) device, as well (iii) manipulation D GV‐DA light‐induced DEP (LiDEP)...

The utility of organic functional units for high-performance materials and devices is highly dependent on the formation ordered domains across extended regimes. As such, development synthetic approaches to achieve precisely material building blocks, a process often complicated by dynamic sensitive nature supramolecular interactions in many molecules, critical realizing efficient emergent physical properties. To this end, we leveraged long-range anisotropic ordering intrinsic class 1D van der...

The anisotropic conduction velocity in cardiac tissues, crucial for ensuring synchronized muscular contractions and overall health, is highly dependent on the orientation of individual myocytes. Similarly, abiotic conducting materials, ordering charge-transporting domains dictate efficiency resulting material. In this study, we present a photocurrent-generating biointerface that investigates sensitivity cardiomyocytes to geometrically comply with biomacromolecular cues differentially...

Precision control over molecular structure-function correlations in adaptive conjugated polymers such as polydiacetylene (PDA) is rarely demonstrated completely aqueous environments due to solvent incompatibility, yet critical for realizing their biomedical applications. For PDAs, the chromogenic transitions that are key stimuli-responsiveness depend on conformation and electronic structure of π-conjugated backbone, which can be influenced by nature flanking, solubilizing groups guide...

The stimuli-responsive chromogenic transitions in polydiacetylenes (PDA) result from the conformational changes that directly alter electronic structure of π-conjugated backbone. In this work, we studied ability electrostatic interactions to modulate chromatic phases afforded by charged, amphiphilic peptide-PDA nanostructures and their coassembly under pH-neutral, aqueous environments. Two oppositely diacetylene-bearing peptide sequences were used as model monomers study. Based on...

Abstract The front cover artwork is provided by Herdeline Ardoña and co‐workers at UC Irvine BioPACIFIC MIP. image illustrates a workflow for supramolecular assembly disassembly processes accessed through carbodiimide‐fueled approach that instructs the self‐assembly hydrolysis‐induced of peptides bearing optoelectronically active units. Read full text Research Article 10.1002/syst.202300003 .

Peptides naturally have stimuli-adaptive structural conformations that are advantageous for endowing synthetic materials with dynamic functionalities. Here, we investigate a carbodiimide-based approach, combined electrostatic modulation, to instruct π-conjugated peptides self-assemble and be responsive thermal disassembly cues upon consumption of the assembly trigger. Quaterthiophene-functionalized utilized as model system herein study formation kinetically trapped structures at...

Precision control over molecular structure-function correlations in adaptive conjugated polymers such as polydiacetylene (PDA) is rarely demonstrated completely aqueous environments due to solvent incompatibility, yet critical for realizing their biomedical applications. For PDAs, the chromogenic transitions that are key stimuli-responsiveness depend on conformation and electronic structure of π-conjugated backbone, which can be influenced by nature flanking, solubilizing groups guide...