A5058329121- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Nanoparticle-Based Drug Delivery
- Parkinson's Disease Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Mitochondrial Function and Pathology
- Mesenchymal stem cell research
- Glioma Diagnosis and Treatment
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Neurotransmitter Receptor Influence on Behavior
- Xenotransplantation and immune response
- Pain Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- 3D Printing in Biomedical Research
- Cerebrospinal fluid and hydrocephalus
- Retinal Development and Disorders
- Advanced biosensing and bioanalysis techniques
Providence College
2007-2020
Mirna Therapeutics (United States)
2018-2020
University of Rhode Island
2020
NsGene (Denmark)
2012-2014
University of South Florida
1993-2013
Incyte (United States)
2007-2012
Weatherford College
2009
California Institute for Regenerative Medicine
2009
Brown University
1991-2005
Veterans Health Administration
2004
Vaccines are largely ineffective for patients with established cancer, as advanced disease requires potent and sustained activation of CD8(+) cytotoxic T lymphocytes (CTLs) to kill tumor cells clear the disease. Recent studies have found that subsets dendritic (DCs) specialize in antigen cross-presentation production cytokines, which regulate both CTLs regulatory (Treg) shut down effector cell responses. Here, we addressed hypothesis coordinated regulation a DC network, plasmacytoid DCs...
Delivery of neurotrophic molecules to the CNS has gained considerable attention as a potential treatment strategy for neurological disorders. In present study, DHFR-based expression vector containing human ciliary factor (hCNTF) was transfected into baby hamster kidney fibroblast cell line (BHK). Using polymeric device, encapsulated BHK-control cells and those secreting hCNTF (BHK-hCNTF) were transplanted unilaterally rat lateral ventricle. Twelve days later, same animals received unilateral...
Effective treatments for neurodegenerative disorders are limited by our inability to alter the progression of diseases. A number proteins have specific neuroprotective activities in vitro; however, delivery these factors into central nervous system over long term at therapeutic levels has been difficult achieve. BHK cells engineered express and release human nerve growth factor were encapsulated an immunoisolation polymeric device transplanted both fimbria-fornix-lesioned rat brains naive...
Choroid plexus (CP) secretes a cocktail of neurotrophic factors. In the present study, CP from neonatal pigs was encapsulated within alginate microcapsules for in vitro and vivo neuroprotective studies.In studies involved serum deprivation rat embryonic cortical neurons treatment with range concentrations conditioned media CP. For studies, rats received 1-hour middle cerebral artery occlusion followed by intracranial transplantation or unencapsulated CP, empty capsules, no transplant....
Vascular endothelial growth factor (VEGF) is a potent proangiogenic peptide and its administration has been considered as potential neuroprotective strategy following cerebral stroke. Because VEGF short half-life limited access to the brain parenchyma systemic administration, approaches are being developed deliver it directly site of infarction. In present study, was incorporated into sustained release hydrogel delivery system examine benefits in rat model ischemia. The loaded with (1 μg)...
Brain-derived neurotrophic factor (BDNF) may represent a therapeutic for chronic epilepsy, but evaluating its potential is complicated by difficulties in delivery to the brain. Here, we describe effects on epileptic seizures of encapsulated cell biodelivery (ECB) devices filled with genetically modified human cells engineered release BDNF. These devices, implanted into hippocampus pilocarpine-treated rats, highly decreased frequency spontaneous more than 80%. benefits were associated...
Cognitive deficits are the most enduring and disabling sequelae of human traumatic brain injury (TBI), but quantifying magnitude, duration, pattern cognitive produced by different types TBI has received little emphasis in preclinical animal models. The objective present study was to use a battery behavioral tests determine if impact sites produce patterns how long can be detected after TBI. Prior surgery, rats were trained criteria on delayed nonmatching position, radial arm maze, rotarod...
R ecent developments in biotechnology have resulted a number of powerful new protein therapies for many heretofore untreatable conditions, including hepatitis C, multiple sclerosis, hormonal disorders, and different cancers. In spite this, the use most drugs is limited by
The present study examined whether implants of epidermal growth factor (EGF)-responsive stems cells derived from transgenic mice in which the glial fibrillary acid protein (GFAP) promoter directs expression human nerve (hNGF) could prevent degeneration striatal neurons a rodent model Huntington's disease (HD). Rats received intrastriatal transplants GFAP-hNGF stem or control followed 9 days later by an injection quinolinic (QA). Nissl stains revealed large lesions rats receiving grafts,...