A5028616356- Immune Cell Function and Interaction
- Autism Spectrum Disorder Research
- T-cell and B-cell Immunology
- Genetics and Neurodevelopmental Disorders
- Immunotherapy and Immune Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Birth, Development, and Health
- Tryptophan and brain disorders
- Cytomegalovirus and herpesvirus research
- Diabetes and associated disorders
- Retinal Development and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Virology and Viral Diseases
- Neuroscience and Neural Engineering
- Cellular transport and secretion
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine regulation and behavior
- Neurological disorders and treatments
- Chromatin Remodeling and Cancer
- Mosquito-borne diseases and control
- Neural dynamics and brain function
- Adenosine and Purinergic Signaling
- Congenital heart defects research
- Telomeres, Telomerase, and Senescence
University of Trento
2014-2025
Universität Innsbruck
2016-2025
Center for Neuroscience and Cognitive Systems
2023
Ludwig Boltzmann Institute for Age Research
2020
The bone marrow (BM) plays a key role in the long-term maintenance of immunological memory. However, impact aging on production survival factors for effector/memory T cells and plasma human BM has not been studied. We now show that expression molecules involved memory changes with age. While IL-15, which protects potentially harmful CD8+ CD28- senescent cells, increases, IL-7 decreases. IL-6, may synergize is also overexpressed. In contrast, proliferation-inducing ligand, cell factor,...
BackgroundThe bone marrow (BM) is a major reservoir of resting memory T cells and long-lived plasma cells, capable providing protection against recurrent infections. Whether the age-related accumulation adipose tissue in BM affects functionality maintenance not well understood.MethodsFor first time, we compare human femur (fMAT) subcutaneous white thigh (tsWAT) obtained from same donors. Therefore, used microarrays for comparative global gene expression analysis, employed assays to analyse...
Abstract After repeated antigen exposure, both memory and terminally differentiated cells can be generated within CD8 + T cells. Although, during their differentiation, activated may first lose CD28, CD28 − eventually express CD57 as a subsequent step, population of (DP) identified in the peripheral blood. How this is distinct from (DN) cells, better characterized non‐activated/early‐activated senescent‐like cell subsets currently unknown. Here, RNA expression four isolated human PBMCs was...
Abstract Abnormal tactile response is an integral feature of Autism Spectrum Disorders (ASDs), and hypo-responsiveness to stimuli often associated with the severity ASDs core symptoms. Patients Phelan-McDermid syndrome (PMS), caused by mutations in SHANK3 gene, show ASD-like symptoms aberrant responses. The neural underpinnings these abnormalities are still poorly understood. Here we investigated, Shank3b−/− adult mice, substrates whisker-guided behaviors, a key component rodents’...
Sensory abnormalities are a common feature in autism spectrum disorders (ASDs). Tactile responsiveness is altered autistic individuals, with hypo-responsiveness being associated the severity of ASD core symptoms. Similarly, sensory have been described mice lacking ASD-associated genes. Loss-of-function mutations CNTNAP2 result cortical dysplasia-focal epilepsy syndrome (CDFE) and autism. Likewise, Cntnap2-/- show deficits relevant symptoms human ASDs, considered reliable model to study ASDs....
Cytomegalovirus (CMV) has been described as a contributor to immunosenescence, thus exacerbating age-related diseases. In persons with latent CMV infection, the CD8+ T cell compartment is irreversibly changed, leading accumulation of highly differentiated virus-specific cells in peripheral blood. The bone marrow (BM) shown play major role long-term survival antigen-experienced cells. Effector are preferentially maintained by cytokine IL-15, expression which increases old age. However, impact...
CD4+ regulatory T cells have been intensively studied during aging, but little is still known about age-related changes of other cell subsets. It was therefore the goal present study to analyze CD8+HLADR+ in old age, a population reported suppressive activity and be connected specific genetic variants. We demonstrate strong increase number with age cohort female Sardinians as well elderly male persons from Austria. also show that lack classical activation molecules such CD69 CD25, contain...
Genome-wide association studies indicated the homeobox-containing transcription factor Engrailed-2 ( En2 ) as a candidate gene for autism spectrum disorders (ASD). Accordingly, knock-out −/− mice show anatomical and behavioral “ASD-like” features, including decreased sociability learning deficits. The molecular pathways underlying these deficits in are not known. Deficits signaling involving neurofibromin extracellular-regulated kinase (ERK) have been associated with impaired learning. Here...
Obesity has been associated with chronic inflammation and oxidative stress. Both conditions play a determinant role in the pathogenesis of age-related diseases, such as immunosenescence. Adipose tissue can modulate function immune system secretion molecules influencing phenotype cells. The importance bone marrow (BM) maintenance antigen-experienced adaptive cells documented mice. Recently, some groups have investigated survival effector/memory T human BM. Despite this, whether high body mass...
Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental Q8 conditions characterized by deficits in social interaction/communication and restrictive/repetitive behaviors. Recent studies highlight the role immune system dysfunction inflammation ASD pathophysiology. Indeed, elevated levels pro-inflammatory cytokines were described brain peripheral blood individuals. Despite this, how this profile evolves with aging whether it may be associated behavioral unknown. In work,...
Fc receptor for IgM (FcμR)-deficient mice display dysregulated function of neutrophils, dendritic cells, and B cells. The relevance FcμR to human T cells is still unknown. We show that mostly stored inside the cell surface expression tightly regulated. Decreased on from elderly individuals associated with alterations in methylation pattern FCMR gene. Binding internalization stimulate transport ensure sustained uptake. Concurrently, accumulates within cell, other receptors increases, among...
Antigen-experienced immune cells migrate back to the bone marrow (BM), where they are maintained in BM survival niches for an extended period. The composition of T cell subpopulations changes with age, leading accumulation highly differentiated and a loss naïve cells. While innate also affected by little is known about interactions between different adaptive populations BM. In this study, phenotype function isolated from human peripheral blood (PB) was analysed detail using flow cytometry,...
Aging is characterized by reduced immune responses, a process known as immunosenescence. Shortly after their generation, antigen-experienced adaptive cells, such CD8+ and CD4+ T migrate into the bone marrow (BM), in which they can be maintained for long periods of time within survival niches. Interestingly, we recently observed how oxidative stress may negatively support maintenance immunological memory BM old age. To assess whether generation could improved scavenging oxygen radicals,...
Abstract Autism Spectrum Disorder (ASD) includes a range of neurodevelopmental disabilities characterized by social interaction deficits, communication impairments, and repetitive behaviors. Previous studies have shown that pro-inflammatory conditions play key role in ASD. Here we reported increased levels molecules related to inflammation are present the cerebellum peripheral blood (PB) mice lacking Shank3b, established model syndromic In parallel, immune dysfunction was documented bone...
Autism spectrum disorder (ASD) includes a range of neurodevelopmental disabilities characterized by social interaction deficits, communication impairments, and repetitive behaviors. Previous studies have shown that pro-inflammatory conditions play key role in ASD. Despite this, how oxidative stress inflammation may contribute to ASD-related behaviors is still poorly understood. Here, we reported increased levels molecules related are present the cerebellum peripheral blood (PB) mice lacking...
Abstract Autism Spectrum Disorder (ASD) is a highly prevalent neurodevelopmental condition characterized by social communication deficits and repetitive/restricted behaviors. Several studies showed that inflammation may contribute to ASD. Here we used RT-qPCR, RNA sequencing, immunohistochemistry, flow cytometry show pro-inflammatory molecules were increased in the cerebellum periphery of mice lacking Cntnap2 ( −/− ), robust model In parallel, oxidative stress was present mutant animals....