A5051998462- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Ion channel regulation and function
- Neuroscience of respiration and sleep
- Pharmacological Effects and Toxicity Studies
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Diet and metabolism studies
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Drug Transport and Resistance Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Photoreceptor and optogenetics research
- Anesthesia and Neurotoxicity Research
- Amino Acid Enzymes and Metabolism
- Biochemical effects in animals
- EEG and Brain-Computer Interfaces
Kent Hastanesi
2020-2025
Acıbadem Adana Hospital
2020-2025
Acıbadem University
2021-2024
Neurosciences Institute
2024
Marmara University
2013-2023
Maltepe University
2020-2022
Eastern Mediterranean University
2018
Weatherford College
2003
Boğaziçi University
1992
Summary: Purpose: To determine potential changes in the plasma concentrations of oxcarbazepine (OXC) and its metabolites during pregnancy puerperium. Methods: Five women receiving OXC monotherapy were followed prospectively Four enrolled first trimester, one woman, 2 weeks before delivery. Steady‐state OXC, active R ‐(‐)‐ S ‐(+)‐monohydroxy derivatives (MHD), additional metabolite carbamazepine‐10,11‐ trans ‐dihydrodiol (DHD) measured at regular intervals by an enantioselective HPLC assay....
Grayanotoxins are known to occur in honey produced from the nectar of Rhododendrons family Ericaceae. extracted sample obtained a patient who experienced severe bradycardia and hypotension after ingesting two tablespoonfuls corresponded Rhododendron ponticum tetrades. Anaesthetized albino rats were injected with extract intracerebroventricularly or intraperitoneally. The intracerebroventricular dose was equivalent 50 mg i.p. doses mg, 1 kg-1 5 g honey. Marked respiratory rate depression...
Most dorsal thalamic nuclei send axons to specific areas of the neocortex and sectors reticular nucleus; then sends reciprocal connections back same nucleus, directly as well indirectly through a relay in nucleus. This can be regarded 'canonical' circuit sensory thalamus. For pathways that link thalamus hippocampal formation, only few comparable have been described. The reuniens nucleus some its major cortical efferents formation. present study shows cells formation are retrogradely labelled...
Originally derived from a Wistar rat strain, proportion of which displayed spontaneous absence-type seizures, Genetic Absence Epilepsy Rats Strasbourg (GAERS) represent the most widely utilized animal model genetic generalized epilepsy. Here we compare seizure, behavioral, and brain morphometric characteristics four main GAERS colonies that are being actively studied internationally: two Melbourne (MELB STRAS-MELB), one Grenoble (GREN), Istanbul (ISTAN).Electroencephalography (EEG)...
Chemokine (CXC motif) ligand 8 (CXCL8) is a pro-inflammatory chemokine binding to CXCR1/2 receptors, elevated in the serum of patients with Temporal Lobe Epilepsy (TLE). Its murine ortholog CXCL1, implicated seizure generation and neuronal loss. This study evaluates anti-epileptogenic anti-seizure effect reparixin, an allosteric antagonist amygdaloid kindling rat model TLE. Reparixin was administered via osmotic pumps (8mg/kg/h) during period over 14 days seizures induced twice daily by...
Chemokine (CXC motif) ligand 8 (CXCL8) is a pro-inflammatory chemokine binding to CXC motif receptors 1/2 (CXCR1/2). Patients with temporal lobe epilepsy (TLE) exhibit increased serum CXCL8 levels. 1 (CXCL1), murine ortholog of CXCL8, has been implicated in seizure generation and neuronal loss. This study evaluated the antiepileptogenic antiseizure effects reparixin amygdaloid kindling rat model TLE. Reparixin was administered during period for 14 days, seizures were induced twice daily via...
The posterior hypothalamic nucleus has been implicated as an area controlling autonomic activity. afferent input to the will provide evidence its role in function. In present study, we aimed identify detailed anatomical projections from cortical, subcortical and brainstem structures, using horseradish peroxidase (HRP) retrograde axonal transport technique rat. Subsequent injection of HRP into nucleus, extensive cell labelling was observed bilaterally various areas cerebral cortex including...
This prospective observational study describes the pharmacokinetic characteristics of favipiravir in adult patients hospitalized for mild to moderate COVID‐19 with a positive RT‐PCR test. Favipiravir was administered 5 days, loading dose 3200 mg and maintenance 1200 mg/day. Serial blood samples were collected on Day 2 4 therapy. Laboratory findings ( n = 21) in‐hospital mortality recorded. concentrations exhibited substantial variability significant decrease during treatment COVID‐19. The...
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and the <i>I</i><sub>h</sub> current they generate contribute to pathophysiological mechanisms of absence seizures (ASs), but their precise role in neocortical thalamic neuronal populations, main components network underlying AS generation, remains controversial. In diverse genetic models, amplitude is smaller neurons either larger or unchanged thalamocortical (TC) compared with nonepileptic strains. A lower expression HCN...
Spontaneous 7–10 Hz spike‐wave discharges (SWDs) are the electroencephalographic hallmark of absence seizures, as can be observed in WAG/Rij well GAERS, two commonly used well‐validated genetic rat models epilepsy. A local upregulation sodium channels within perioral region primary somatosensory cortex indicated an initiation site for SWDs rats, line with a new theory that assumes have cortical focal origin cortex. We tested whether bilateral microinfusion at this channel blocker phenytoin,...
We showed previously that genetic absence epilepsy rats from Strasbourg (GAERS) resist secondary generalization of focal limbic seizures after electrical kindling. now investigate the effect intra-amygdaloid injection kainic acid, as another model temporal lobe epilepsy, focusing on epileptogenesis, spike-and-wave discharges (SWDs), and transition basal to SWD states in GAERS. The EEG was recorded hippocampus cortex adult GAERS Wistar before acid injections into basolateral amygdala for 3...
Summary: The involvement of the thalamus in limbic epileptogenesis has recently drawn attention to connectivity between nuclei and structures. Thalamo‐limbic circuits are thought regulate seizure activity whereas thalamocortical involved expression generation spike‐and‐wave discharges (SWDs) absence epilepsy models. Genetic Absence Epilepsy Rats From Strasbourg (GAERS) WAG/Rij (Wistar Albino Glaxo from Rijswijk) well‐defined genetic animal models epilepsy. We aimed examine duration...
Drug-drug interactions (DDIs) can impact patient safety. Occurrence of clinically important DDIs is higher for intensive care unit (ICU) patients. This observational study aimed to evaluate the potential in medical ICU patients a university hospital.The Medical Pharmacology Department organized consultation reports order detect DDIs. To focus on DDIs, C, D, or X risk rating categories Lexi-Interact online database were analyzed. Frequency and clinical detected. Relationship between number...