A5021904397- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Nitric Oxide and Endothelin Effects
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Blood Pressure and Hypertension Studies
- Renin-Angiotensin System Studies
- Cerebrovascular and Carotid Artery Diseases
- Sodium Intake and Health
- Cardiac and Coronary Surgery Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Ischemia and Reperfusion
- Frailty in Older Adults
- Radiation Dose and Imaging
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Receptor Mechanisms and Signaling
- Aortic aneurysm repair treatments
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Healthcare Systems and Public Health
Freeman Hospital
2015-2024
Institute of Catalysis and Petrochemistry
2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2014-2024
Newcastle University
2012-2023
Radiance Technologies (United States)
2023
Forth Valley Royal Hospital
2017
Ziekenhuis Oost-Limburg
2017
Institut Arnault Tzanck
2017
St. Antonius Ziekenhuis
2017
Toronto Public Health
2014
Collecting duct (CD)-derived endothelin-1 (ET-1) inhibits renal Na reabsorption and its deficiency increases blood pressure (BP). The role of CD endothelin B (ETB) receptors in mediating these effects is unknown. CD-specific knockout the ETB receptor was achieved using an aquaporin-2 promoter-Cre recombinase transgene loxP-flanked gene (CD KO). Systolic BP mice with receptor, ETA KO) ET-1 KO), their respective controls were compared during normal- high-salt diet. On a normal-sodium diet, KO...
<h3>Objectives</h3> Treatment options for coronary chronic total occlusions (CTO) are limited, with low historical success rates from percutaneous intervention (PCI). We report procedural outcomes of CTO PCI 7 centres dedicated operators trained in hybrid approaches comprising antegrade/retrograde wire escalation (AWE/RWE) and dissection re-entry (ADR/RDR) techniques. <h3>Methods</h3> Clinical data were collected consecutive unselected patients between 2012 2014. Lesion complexity was graded...
Lymphocytes contribute to ischemia/reperfusion (I/R) injury in several organ systems, but their relevance ST elevation myocardial infarction (STEMI) is unknown. Our goal was characterize lymphocyte dynamics individuals after primary percutaneous coronary intervention (PPCI), assess the prognostic of these cells, and explore mechanisms lymphocyte-associated injury.Lymphocyte counts were retrospectively analyzed 1,377 STEMI patients, post-PPCI lymphopenia assessed by Cox proportional hazards...
The collecting duct (CD) endothelin (ET) system regulates blood pressure (BP) and Na excretion. CD-specific knockout (KO) of ET-1 causes hypertension, KO the ETA receptor does not alter BP, while ETB increases BP to a lesser extent than CD KO. These findings suggest paracrine role for CD-derived ET-1; however, they do exclude compensation loss one ET by other. To examine this, mice with both receptors were generated (CD ETA/B KO). excreted less urinary controls during acute or chronic...
To examine: (i) the temporal changes in management pattern; (ii) reasons for any treatment disparities; (iii) relationship between invasive and outcome, among acute coronary syndrome (ACS) patients with vs. without kidney dysfunction.Canadian ACS I, II registries Global Registry of Acute Coronary Events (GRACE) were prospective, multi-centre, observational studies ACS. From 1999 to 2007, non-ST elevation (NSTE) recruited I (n = 3295; 1999-2001), 1956; 2002-2003), GRACE 6491; 2004-2007)...
Objectives This study sought to create a contemporary scoring tool predict technical outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) from patients treated by hybrid operators with differing experience levels. Background Current systems need regular updating cope the positive evolutions regarding materials, techniques, and outcomes, while at same time being applicable for broad range operators. Methods Clinical angiographic characteristics 880 CTO‐PCIs...
Despite advances in understanding the physiological role of collaterals coronary chronic total occlusions (CTOs), collateral anatomy remains poorly defined. Our aim was to define and interventional utility within a large population patients with CTOs.We studied angiograms 481 519 CTOs at six centres U.K. over four years. Detailed angiographic analysis performed by cardiologists specialising CTO percutaneous intervention (PCI). All visible connection (CC) grade ≥1 were recorded. A subgroup...
Three-dimensional (3D) printing is a manufacturing process in which an object created by specialist printers designed to print additive layers create 3D object. Whilst there are initial promising medical applications of printing, lack evidence support its use remains barrier for larger scale adoption into clinical practice. Endovascular virtual reality (VR) simulation plays important role the safe training future endovascular practitioners, but existing VR models have disadvantages including...
Endothelin B receptors in different tissues regulate diverse physiological responses including vasoconstriction, vasodilatation, clearance of endothelin-1, and renal tubular sodium reabsorption. To examine the role endothelial cell endothelin these processes, we generated cell-specific receptor knockout mice using a Cre- loxP approach. We have demonstrated loss expression function preservation nonendothelial receptor-mediated through binding functional assays. Ablation exclusively from cells...
Acute coronary syndrome (ACS) patients in the highest risk categories are least likely to receive evidence-based treatments (EBTs). We sought determine why physicians do not prescribe EBTs for with non-ST-segment-elevation ACSs and factors determining use of these after 1 year.One thousand nine hundred fifty-six ACS were enrolled prospective, multicenter Canadian registry II between October 2002 December 2003. Each patient's physician gave reasons guideline-indicated medication(s) was...
Development of the CrossBoss and Stingray devices for antegrade dissection reentry (ADR) chronic total occlusions has improved historically suboptimal outcomes. However, outcomes, safety, failure modes technique have to be studied in a larger patient cohort. This preplanned substudy RECHARGE registry (Registry Hybrid Procedures France, Netherlands, Belgium United Kingdom) aims evaluate value use ADR determine its future position contemporary occlusion intervention.Patients were selected if...
Background— Small observational studies demonstrate the feasibility of transradial approach for chronic total occlusion (CTO) percutaneous coronary intervention. The aim current study is to assess technical success, complication rates, and procedural efficiency in fully (fTRA) transfemoral (TFA) a large prospective European registry adopting hybrid algorithm CTO intervention (Registry CrossBoss Hybrid Procedures France, Netherlands, Belgium United Kingdom, RECHARGE registry). Methods...
Inactivation of endothelin B receptors (ET ), either through selective pharmacological antagonism or genetic mutation, increases the circulating concentration endothelin-1 (ET-1), suggesting ET plays an important role in clearance this peptide. However, cellular site -mediated has not yet been determined. We have used a novel mouse model endothelial cell-specific knockout (KO) (EC –/– ) to evaluate relative contribution EC-ET ET-1. Phenotypic evidence EC-specific KO was confirmed by...
Early identification of higher risk patients presenting with ST-elevation myocardial infarction (STEMI) and undergoing primary percutaneous coronary intervention (PPCI) will allow a more aggressive strategy approach. The aim this study was to evaluate the shock index (ratio heart rate/systolic blood pressure on admission) as predictor mortality post PPCI in addition other parameters. We analysed prospectively collected data 3049 STEMI treated large tertiary centre between March 2008–December...
AimsTo assess the impact of thrombus aspiration during primary percutaneous coronary intervention (PPCI) on mortality patients with ST-elevation myocardial infarction (STEMI) patients.
Percutaneous coronary intervention for complex disease is associated with a high risk of cardiogenic shock. This can cause harm and limit the quality revascularization achieved, especially when left ventricular function impaired at outset. Elective percutaneous unloading increasingly used to mitigate adverse events in patients undergoing high-risk intervention, but this strategy has fiscal clinical costs not supported by robust evidence.
We aimed to determine clinical outcomes 1 year after successful chronic total occlusion (CTO) PCI and, in particular, whether use of dissection and re‐entry strategies affects outcomes. Hybrid approaches have increased the procedural success CTO percutaneous coronary intervention (PCI) but longer‐term are unknown, particularly relation techniques. Data were collected for consecutive PCIs performed by hybrid‐trained operators from 7 United Kingdom (UK) centres between 2012 2014. The primary...
There is mounting evidence of a higher incidence coronary heart disease in cytomegalovirus-seropositive individuals.The aim this study was to investigate whether acute myocardial infarction triggers an inflammatory T-cell response that might lead accelerated immunosenescence patients.Thirty-four patients with undergoing primary percutaneous intervention were longitudinally studied within 3 months after reperfusion (Cohort A). In addition, 54 and chronic analyzed cross-sectional B)....