A5069547800- Gut microbiota and health
- Ancient Mediterranean Archaeology and History
- Liver Disease and Transplantation
- Vascular Procedures and Complications
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Orthopedic Infections and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Theatre and Performance Studies
- Aortic aneurysm repair treatments
- Archaeology and Historical Studies
- Advanced Surface Polishing Techniques
- Spine and Intervertebral Disc Pathology
- Gastrointestinal motility and disorders
- Central Venous Catheters and Hemodialysis
- Colorectal Cancer Screening and Detection
- Canadian Identity and History
- Abdominal vascular conditions and treatments
- Streptococcal Infections and Treatments
- Soil Carbon and Nitrogen Dynamics
- Weed Control and Herbicide Applications
- Congenital Heart Disease Studies
- Theater, Performance, and Music History
- Long-Term Effects of COVID-19
- Vascular anomalies and interventions
Mayo Clinic in Florida
2016-2025
Mayo Clinic
2017-2024
University of Central Florida
2022
WinnMed
2020-2022
Mayo Clinic in Arizona
2017-2021
Washington State University
2021
Idaho National Laboratory
2020
Colorado Permanente Medical Group
2009-2020
University of Virginia
2017
Montana State University
2016-2017
Abstract Globally breast cancer is the leading cause of death among women. The consists epithelium, stroma and a mucosal immune system that make up complex microenvironment. Growing awareness role microbes in microenvironment recently has led to series findings important for human health. microbiome been implicated development progression at variety body sites including stomach, colon, liver, lung skin. In this study, we assessed tissue microbial signatures intraoperatively obtained samples...
Adenomatous polyps are the most common precursor to colorectal cancer, second leading cause of cancer-related death in United States. We sought learn more about early events carcinogenesis by investigating shifts gut microbiota patients with adenomas.We analyzed 16S rRNA gene sequences from fecal adenomas (n = 233) and without 547).Multiple taxa were significantly abundant adenomas, including Bilophila, Desulfovibrio, proinflammatory bacteria genus Mogibacterium, multiple Bacteroidetes...
This study examines the anatomic distribution of emboli on pulmonary angiography and attempts to determine relationship vessel size interobserver agreement, two factors having important implications in comparing with cross-sectional imaging for embolism.One hundred twenty-five consecutive angiograms were reviewed retrospectively by three interventional radiologists. Initial interpretations recorded compared agreement a per-patient per-embolus basis. Discordant all radiologists consensus...
The inflammatory tumoral-immune response alters the physiology of tumor microenvironment, which may attenuate genomic instability. In addition to inducing immune responses, several pathogenic bacteria produce genotoxins. However extent microbial contribution microenvironment biology remains unknown. We utilized Cancer Genome Atlas, (TCGA) breast cancer data perform a novel experiment utilizing unmapped and mapped RNA sequencing read evidence minimize laboratory costs effort. Our objective...
Objective The intestinal lumen contains several proteases. Our aim was to determine the role of faecal proteases in mediating barrier dysfunction and symptoms IBS. Design 39 patients with IBS 25 healthy volunteers completed questionnaires, assessments vivo permeability, ex colonic function Ussing chambers, tight junction (TJ) proteins, ultrastructural morphology 16 s sequencing microbiota rRNA. A casein-based assay used measure proteolytic activity (PA) supernatants (FSNs). Colonic...
1. Modernist writers and the ethos of professionalism 2. Fiction from a newspaperised world: Henry James's The Reverberator 3. newspaperman kicked out: Sacred Fount literary authority 4. plots murder: un/original stories in Theodore Dreiser's An American Tragedy 5. Reading John Dos Passos: reading mass culture USA 6. Miss Lonelyhearts: Nathanael West's comic-strip novel 7. Making usual kind sense: Hollywood, West critics Day Locust Notes Reference List Index.
There are altered mucosal functions in irritable bowel syndrome with diarrhoea (IBS-D); ~30% of patients IBS-D have abnormal bile acid (BA) metabolism (ABAM) and (summarised as BAD).
The purpose of this research was to study the efficacy and outcomes transjugular intrahepatic shunt (TIPS) in end-stage liver disease (ESLD) patients with portal vein thrombosis (PVT) eligible for orthotopic transplant. Nine consecutive PVT underwent TIPS as a nonemergent elective outpatient procedure. primary indication maintain patency optimal surgical outcome. Eight contrast enhanced computed tomography (CT) 1 magnetic resonance imaging diagnosing PVT. Shunt creation determined by...
PURPOSE: To prospectively determine the safety and efficacy of gadolinium-based blood pool magnetic resonance (MR) imaging contrast agent gadofosveset in patients known to have or suspected having peripheral vascular disease. MATERIALS AND METHODS: Ethical committee approval patient written informed consent were obtained. This study was compliant with Health Insurance Portability Accountability Act. Adults disease received (0.03 mmol per kilogram body weight) for MR angiography aortoiliac...
Recent human microbiome studies have revealed an essential role of the in health and disease, opening up possibility building microbiome-based predictive models for individualized medicine. One unique characteristic data is existence a phylogenetic tree that relates all microbial species. It has frequently been observed cluster or clusters bacteria at varying depths are associated with some clinical biological outcome due to shared function (clustered signal). Moreover, many cases, we...
Stromal and immune cell composition alterations in benign breast tissue associate with future cancer risk. Pilot data suggest the innate microbiome of normal differs between women without cancer. Microbiome might explain microenvironment variations associated disease status.Prospectively-collected sterile tissues from (n=16) or malignant (n=17) underwent 16SrRNA sequencing Illumina MiSeq Hybrid-denovo pipeline processing. Breast was scored for fibrosis fat percentages infiltrates (lobulitis)...
Primary sclerosing cholangitis (PSC) is a major risk factor for cholangiocarcinoma (CCA). We investigated biliary and fecal microbiota to determine whether specific microbes in the bile or stool are associated with PSC CCA.Bile was obtained from 32 patients PSC, 23 CCA 26 without 17 controls. Over 90% of samples were perihilar CCA. Stool 31 (11 matched bile), 16 (10 11 (6 bile). Microbiota composition assessed using 16SrRNA-marker-based sequencing compared between groups.Bile has unique...
Abnormalities in the gut microbiome are associated with suppressed Th2 response (Belizario et al., 2018 Mediators Inflamm. 2018:2037838) and predisposition to atopic disease such as asthma eczema. We investigated if this applies eosinophilic esophagitis (EoE). Stool bacterial DNA was extracted followed by 16S rRNA amplification from 12 patients controls. Alpha- beta-diversity were analyzed. Only two had or atopy one patient on budesonide. No PPIs. Patients EoE lower microbiota alpha...
Preterm birth (PTB) is the largest contributor to infant death in sub-Saharan Africa and globally. With a global estimate of 773,600, Nigeria has third highest rate PTB worldwide. There have been number microbiome profiling studies identify vaginal microbiomes suggestive preterm healthy outcome. However, on pregnancy are sparse with none performed Nigeria. Moreover, few considered concurrent impact steroid hormones We assessed two key determinants progression gain deeper understanding...