A5102880004- Pharmaceutical and Antibiotic Environmental Impacts
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Environmental Toxicology and Ecotoxicology
- Carcinogens and Genotoxicity Assessment
- Retinal Diseases and Treatments
- Cancer-related molecular mechanisms research
- Advanced Computational Techniques and Applications
- Heat Transfer and Optimization
- Evaluation Methods in Various Fields
- Glaucoma and retinal disorders
- Computational Drug Discovery Methods
- Pesticide and Herbicide Environmental Studies
- Retinal Imaging and Analysis
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Sensor and Control Systems
- Power Quality and Harmonics
- Flavonoids in Medical Research
- Environmental remediation with nanomaterials
- Traditional Chinese Medicine Analysis
- Advanced biosensing and bioanalysis techniques
- Mycobacterium research and diagnosis
- Power Systems Fault Detection
- Whipple's Disease and Interleukins
- Electrical and Bioimpedance Tomography
Hefei University of Technology
2024
Twelfth Guangzhou City People's Hospital
2018-2022
First People’s Hospital of Jingmen
2019-2022
Hubei University of Chinese Medicine
2021
RWTH Aachen University
2013-2020
Heilongjiang Provincial Hospital
2018
Electric Power Research Institute
2018
South Central Minzu University
2014-2017
State Ethnic Affairs Commission
2017
Daqing Oilfield General Hospital
2016
Interest in the risks posed by trace concentrations of pharmaceuticals and personal care products (PPCPs) surface waters is increasing, particularly with regard to potential effects long-term, low-dose exposures aquatic organisms. In most cases, actual studies on PPCPs were risk assessments at screening-level, accurate estimates scarce. this study, exposure ecotoxicity data 50 collected based our previous studies, a multiple-level environmental assessment was performed. The selected are...
The construction of the Three Gorges Dam (TGD) in Yangtze River raises great concern ecotoxicological research since large amounts pollutants enter Reservoir (TGR) water bodies after TGD impoundment. In this work, effect-directed analysis (EDA), combining effect assessment, fractionation procedure, and target nontarget analyses, was used to characterize aryl hydrocarbon receptor (AhR) agonists sediments TGR. Priority polycyclic aromatic hydrocarbons (PAHs) containing four five rings were...
Tricolsan (TCS), an antimicrobial agent, is considered as emerging pollutant due to its wide dispersive use in personal care products and high aquatic toxicity. In the present study, phase I metabolism of triclosan was investigated through laboratory electrochemical simulation studies. The formed (EC) cell were identified by online offline coupling with QTRAP high-resolution FTICR mass spectrometers, respectively. sequential formation disappearance each product, continuous increase voltage...
Effect-directed analysis (EDA) is a powerful strategy to identify biologically active compounds in environmental samples. However, current EDA studies, fractionation and handling procedures are laborious, consist of multiple evaporation steps, thus bear the risk contamination decreased recoveries target compounds. The low resulting throughput has been one major bottlenecks EDA. Here, we propose high-throughput (HT-EDA) work-flow combining reversed phase high-performance liquid chromatography...
Diabetic retinopathy is a major complication of diabetes. Increasing evidence has indicated that microRNAs (miRs) serves an important role in diabetic retinopathy. However, the expression and mechanism miR‑217 high glucose‑induced human retinal pigment epithelial cells ARPE‑19 still unclear. Therefore, aim this study was to investigate cell damage, further explore molecular mechanisms. In our study, we found compared with control group, upregulated cells. addition, TargetScan dual‑luciferase...
Diabetic retinopathy (DR) is one of the most common microvascular complications diabetes mellitus, which leads to neuronal and vascular dysfunction in retina with a final outcome complete loss vision. The aim present study was investigate effects dihydromyricetin (DHM), natural flavanol compound, on diabetic identify its potential mechanisms.Retinal pigment epithelial cell line (ARPE-19) treated high glucose (HG) used simulate DR model vitro. After treatment different concentrations DHM,...
In this study, in vitro bioassays were performed to assess the ecotoxicological potential of sediments from Yangtze River estuary. The cytotoxicity and aryl hydrocarbon receptor (AhR)-mediated toxicity sediment extracts with rainbow trout (Oncorhynchus mykiss) liver cells determined by neutral red retention 7-ethoxyresorufin-O-deethylase assays. AhR-mediated activity estuary ranged low level moderate compared ecotoxicity other river systems. However, releases approximately 14 times greater...
The traditional Chinese medicine Scutellaria barbata D. Don (S. barbata) has been reported to exhibit anti-cancer and anti-inflammation activities. ethanol extract of S. confirmed attenuate diabetic retinopathy (DR). This study aimed investigate the effects underlying mechanisms polysaccharides isolated from (PSB) on proliferation angiogenesis retinal vascular endothelial cells (RVECs) in DR.Human RVECs (HRVECs) were cultured normal glucose (NG, 5.5 mM), mannitol (MA, 30 high (HG, mM) HG...
Microarray expression profiles of lncRNAs and mRNAs were investigated in HepG2 cells treated with 20 μg/ml ginsenoside Rh2 as well Rh2-untreated cells. analysis showed 618 upregulated 161 downregulated compared the control group. Moreover, three differentially expressed validated by quantitative real-time polymerase chain reaction (qRT-PCR). This may be beneficial to patients an anti-cancer treatment potentially provide novel targets for HCC (hepatocellular carcinoma) therapy.
Sediments in estuaries are of important environmental concern because they may act as pollution sinks and sources to the overlying water body. These sediments can be accumulated by benthic organisms. This study assessed mutagenic potential sediment extracts from Yangtze River estuary using Ames fluctuation assay with Salmonella typhimurium his (-) strain TA98 (frameshift mutagen indicator) TA100 (baseshift indicator). Most samples were TA98, regardless presence or absence exogenous metabolic...
This study aimed to estimate the prevalence of visual impairment and identify factors associated with it in China.Data for this cross-sectional were retrieved from China Health Retirement Longitudinal Study (CHARLS) a total 16,480 subjects who completed questionnaire between June 2011 March 2012. The was estimated considering complex survey design response rate. Associated identified using weighted logistic regression analysis.The overall among middle-aged older Chinese adults 6.22%....