A5036199657- Gut microbiota and health
- Eosinophilic Esophagitis
- Inflammatory Bowel Disease
- Gastroesophageal reflux and treatments
- Immune Cell Function and Interaction
- Maternal and fetal healthcare
- Cytomegalovirus and herpesvirus research
- Gestational Trophoblastic Disease Studies
- Helicobacter pylori-related gastroenterology studies
- Metabolism, Diabetes, and Cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pregnancy and preeclampsia studies
- Digestive system and related health
- Gastrointestinal disorders and treatments
- IL-33, ST2, and ILC Pathways
- Gastrointestinal motility and disorders
- Immune Response and Inflammation
- Genetic Syndromes and Imprinting
- Microscopic Colitis
- Sarcoma Diagnosis and Treatment
- Infant Nutrition and Health
- Histiocytic Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Genomic variations and chromosomal abnormalities
- Neonatal Respiratory Health Research
The University of Texas Health Science Center at Houston
2012-2024
Women & Infants Hospital of Rhode Island
2022-2024
Providence College
2022-2024
Brown University
2024
Baylor College of Medicine
2005-2015
Texas Children's Hospital
2006-2015
The University of Texas at Austin
2012-2015
University of Houston
2009
Boston Children's Hospital
2006
Regulatory T (T reg) cell deficiency causes lethal, CD4+ cell–driven autoimmune diseases. Stem transplantation is used to treat these diseases, but this procedure limited by the availability of a suitable donor. The intestinal microbiota drives host immune homeostasis regulating differentiation and expansion reg, Th1, Th2 cells. It currently unclear if reg deficiency–mediated disorders can be treated targeting enteric microbiota. Here, we demonstrate that Foxp3+ results in gut microbial...
Hyperinsulinemic hypoglycemia is the most common cause of severe, persistent neonatal hypoglycemia. The treatment hyperinsulinemic that unresponsive to diazoxide subtotal pancreatectomy. We examined effectiveness mammalian target rapamycin (mTOR) inhibitor sirolimus in four infants with severe had been maximal doses (20 mg per kilogram body weight day) and octreotide (35 μg day). All patients a clear glycemic response sirolimus, although one patient required small dose maintain...
The connection between intestinal micro-biota and host physiology is increasingly becoming recognized. details of this dynamic interaction, however, remain to be explored. Toll-like receptor 2 (Tlr2) important for its role in bacterial recognition, inflammation, obesity-related metabolic changes. Therefore, we sought determine the epigenomic metagenomic consequences Tlr2 deficiency colonic mucosa mice gain insights into biological pathways that shape interface gut mammalian host. Colonic...
Background and aims: Bacteriotherapy aimed at addressing dysbiosis may be therapeutic for Inflammatory Bowel Diseases (IBDs). We sought to determine if defined Bacteroides-based bacteriotherapy could an effective consistent alternative fecal microbiota transplantation (FMT) in a murine model of IBD. Methods: induced experimental colitis 8- 12-week-old C57BL/6 mice using 2-3% dextran sodium sulfate. Mice were simultaneously treated by oral gavage with triple-Bacteroides cocktail, individual...
It is unclear whether the broad inflammatory response shown in neonatal necrotizing enterocolitis (NEC) cause or effect of tissue injury. Toll-like receptors (TLRs) on intestinal dendritic, mononuclear, and epithelial cells recognize bacterial ligands damaged tissues, thus activating response. The present study aimed to determine active TLR signaling would precede histological injury NEC. Newborn rat pups were divided into four groups: dam fed, fed-hypoxic, formula fed-hypoxic (NEC). ileal...
Decreased consumption of dietary fibers, such as cellulose, has been proposed to promote the emergence inflammatory bowel diseases (IBD: Crohn disease [CD] and ulcerative colitis [UC]) where intestinal microbes are recognized play an etiologic role. However, it is not known if transient fiber during critical developmental periods may prevent consecutive inflammation. The incidence IBD peaks in young adulthood indicating that pediatric environmental exposures be important etiology this group....
The question of whether DNA methylation contributes to the stabilization gene expression patterns in differentiated mammalian tissues remains controversial. Using genome-wide profiling, we screened 3757 promoters for changes during postnatal liver development test hypothesis that developmental and are temporally correlated. We identified 31 genes gained 111 lost from embryonic day 17.5 21. Promoters undergoing tended not be associated with CpG islands. At most studied, promoter were changes,...
Abdominal pain is the most common indication for oesophagogastroduodenoscopy (OGD) in children. However, existing studies examining diagnostic outcomes of OGD children with abdominal are limited.
Monozygotic twin and other epidemiologic studies indicate that epigenetic processes may play an important role in the pathogenesis of inflammatory bowel diseases commonly affect colonic mucosa. The peak onset these disorders young adulthood suggests changes normally occurring mucosa shortly before could be etiologic factors. We assessed developmental colitis susceptibility during physiologically relevant period childhood mice [postnatal day 30 (P30) to P90] concurrent DNA methylation gene...
Abstract Background Regulatory T cell (Treg) deficiency leads to IPEX syndrome, a lethal autoimmune disease, in Human and mice. Dysbiosis of the gut microbiota Treg-deficient scurfy (SF) mice has been described, but date, role remains be determined. Results To examine how antibiotic-modified can inhibit Treg deficiency-induced inflammation SF mice, were treated with three different antibiotics. Different antibiotics resulted distinct metabolome changes led varied efficacy prolonging lifespan...
Clear cell sarcoma of soft tissue (CCS-ST) is a rare malignant neoplasm characterized by tumor-defining translocation [t(12;22) (q13;q12)], resulting in the EWS-ATF1 gene fusion. An extremely limited number visceral CCS-ST cases have been reported literature. Here authors report Hispanic adolescent male with large infiltra-tive mass involving small bowel. The tumor was evaluated light microscopy, immunocytochemistry, electron cytogenetics, and molecular genetics. cells were strongly positive...
Dietary influences may affect microbiome composition and host immune responses, thereby modulating propensity toward inflammatory bowel diseases (IBDs): Crohn disease (CD) ulcerative colitis (UC). n-6 fatty acids have been associated with UC in prospective studies. However, the critical developmental period when (n-6) consumption induce is not known. We examined effects of transiently increased during pediatric development on subsequent dextran-sulfate-sodium (DSS)-induced acute murine...
Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS; OMIM%249210) is a rare and severe form of congenital intestinal urinary dysfunction malformation. Histologic studies suggest that the predominant manifestation smooth muscle myopathy. Molecular observations have linked disease to neuronal nicotinic acetylcholine receptor (ηAChR), namely absence functional α3 subunit ηAChR in patients with MMIHS. We describe case MMIHS association de novo deletion proximal long arm chromosome...
ABSTRACT Objectives: Multiple characteristics of industrialization have been proposed to contribute the global emergence inflammatory bowel diseases (IBDs: Crohn disease and ulcerative colitis). Major changes in eating habits during last decades effectiveness exclusive enteral nutrition treatment indicate etiologic importance dietary intake IBDs. A uniform characteristic developing countries (where incidence IBD is low) their consistent nature for prolonged periods; however, potentially...
Zika virus is increasingly recognized as a fetal pathogen worldwide. We describe the first case of neonatal demise with travel-associated infection in United States America, including novel prenatal ultrasound finding. A young Latina presented to our health care system Southeast Texas for at 23 weeks gestation. Fetal Dandy-Walker malformation, asymmetric cerebral ventriculomegaly, single umbilical artery, hypoechoic knee, dorsal foot edema, and mild polyhydramnios were noted upon initial...
Abstract Objective Preeclampsia is a multifactorial placental disease that can occur after delivery. The pathophysiology of postpartum preeclampsia remains unknown. objective was to describe findings in preeclampsia. Study Design This case–control study, comparing the histologic four groups 30 patients with preeclampsia, early-onset late-onset and normotensive controls. Results Placentas had mean weight not different from at similar gestational age (479.0 ± 152.7 vs. 521.3 144.1 g, p =...