A5031218271- Extracellular vesicles in disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- CRISPR and Genetic Engineering
- Chronic Disease Management Strategies
- Delphi Technique in Research
- Viral Infections and Vectors
- Childhood Cancer Survivors' Quality of Life
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Nutrition, Genetics, and Disease
- PARP inhibition in cancer therapy
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Nanocluster Synthesis and Applications
- Lung Cancer Diagnosis and Treatment
University of Aveiro
2021-2025
University Medical Center Groningen
2025
University of Groningen
2025
Institute for Biomedicine
2021
Objective Reduced functional capacity and muscle weakness are two major contributors to impairment in chronic obstructive pulmonary disease (COPD). The underlying causes of poorly understood and, therefore, we sought investigate the contribution genetic factors. Methods We conducted a cross-sectional analysis sociodemographic, clinical information people with COPD. Hierarchical clustering based on (6-minute walk test 1-minute sit-to-stand test) strength (quadriceps isometric handgrip...
Exosomes are small extracellular vesicles (EVs) present in human biofluids that can transport specific disease-associated molecules. Consequently blood-derived exosomes have emerged as important peripheral biomarker sources for a wide range of diseases, among them Alzheimer's disease (AD). Although there is no effective cure AD, an accurate diagnosis, relying on easily accessible biofluids, still necessary to discriminate this from other dementias, test potential therapies and even monitor...
Background Populations seem to respond differently the global pandemic of severe acute respiratory syndrome coronavirus 2. Recent studies show individual variability in both susceptibility and clinical response COVID-19 infection. People with chronic obstructive pulmonary disease (COPD) constitute one risk groups, being already associated a poor prognosis upon This study aims contributing unveil underlying reasons for such people COPD observed across worldwide populations, by looking at...
The potential of exosomes as biomarker resources for diagnostics and even therapeutics has intensified research in the field, including context Alzheimer´s disease (AD). search biomarkers peripheral biofluids is advancing mainly due to easy access it offers. In study presented here, emphasis was given bioinformatic identification putative exosomal candidates AD. proteomes cerebrospinal fluid (CSF), serum plasma, were obtained from three databases (ExoCarta, EVpedia Vesiclepedia),...
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Genetic predisposition for meaningful health-domains of daily life such as peripheral muscle weakness and reduced functional capacity in patients with COPD is yet unknown. We aimed to find genetic variants associated status. A cross-sectional study was conducted. Peripheral strength assessed quadriceps maximum voluntary contraction handgrip strength. Functional determined using the six-minute walk test 1-minute sit-to-stand test. Hierarchical cluster analysis based on principal component...
Reduced exercise capacity and muscle weakness are two major contributors to impaired functional status in chronic obstructive pulmonary disease (COPD). The underlying causes of impairment poorly understood and, therefore, we sought investigate the contribution genetic factors.We conducted a cross-sectional analysis sociodemographic, clinical, information people with COPD. Hierarchical clustering based on (6-minute walk test 1-minute sit-to-stand test) strength (quadriceps isometric handgrip...
People with COPD vary substantially on their pulmonary (e.g., airway obstruction) and extra-pulmonary symptoms, functional status) manifestations. The aim of this study was to relate high heterogeneity the patient's genetic Background, namely focusing polymorphisms associated COPD-associated phenotypes features. Summary statistics for features (emphysema, FEV1, FEV1/FVC, smoking, BMI, asthma, responsiveness, coronary heart disease, blood pressure, artery enlargement, resting rate oxygen...
Abstract Exosomes are small extracellular vesicles (EVs) present in human biofluids that can transport specific disease-associated molecules. Consequently blood-derived exosomes have emerged as important peripheral biomarker sources for a wide range of diseases, among them Alzheimer’s disease (AD). Although there is no effective cure AD, an accurate diagnosis, relying on easily accessible biofluids, still necessary to discriminate this from other dementias, test potential therapies and even...
Populations respond differently to the current global pandemic of covid-19. This study explores role individual factors in differential response covid-19, by looking at genetic background worldwide populations. Significant SNPs (susceptibility: rs286914/rs12329760; severity: rs657152/rs11385942) were selected from literature and their allelic frequencies used calculate probability having multiple risk alleles each population. Portuguese (n=623), Spanish (n=9761) Italian (n=6363) populations...
There is strong individual variability in both susceptibility and clinical response to covid-19 infection. People with chronic obstructive pulmonary disease (COPD) constitute one of risk groups for poor outcomes upon This study contributes unveil the underlying reasons such by looking at genetic background people COPD. 255 COPD (66±9y; 72%♂; FEV1 53.01±20.31pp) 243 controls (67±10y; 80%♂; 100.46±19.19pp) were clinically characterized genotyped using saliva samples. Covid-19 associated SNPs...
Abstract Background Exosomes are small extracellular vesicles (EVs) present in human biofluids that can carry disease-specific molecules. Blood-derived exosomes emerged as interesting peripheral sources of biomarkers for a wide range diseases, and their potential is also being addressed Alzheimer’s disease (AD) context. There no effective cure or blood-based molecular diagnostic tools first clinical AD screening, which motivates research this area to identify putative valuable blood-derived...