A5025799283- Bone Metabolism and Diseases
- Metabolism, Diabetes, and Cancer
- RNA Research and Splicing
- Bone health and osteoporosis research
- Diabetes Treatment and Management
- Veterinary Pharmacology and Anesthesia
- COVID-19 Clinical Research Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Immune cells in cancer
- Bioinformatics and Genomic Networks
- Diabetes and associated disorders
- Epigenetics and DNA Methylation
- Bone health and treatments
- Anesthesia and Neurotoxicity Research
- Pancreatic function and diabetes
- Growth Hormone and Insulin-like Growth Factors
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Pediatric Pain Management Techniques
- Biomarkers in Disease Mechanisms
- Science and Education Research
- Pituitary Gland Disorders and Treatments
- Osteomyelitis and Bone Disorders Research
- Proteins in Food Systems
Hammersmith Hospital
2020-2023
Imperial College London
2017-2023
Royal Veterinary College
2015-2018
Centre for Inflammation Research
2017
Centre National de la Recherche Scientifique
2001
Iron is an essential metal that fine-tunes the innate immune response by regulating macrophage function, but integrative view of transcriptional and metabolic responses to iron perturbation in macrophages lacking. Here, we induced acute chelation primary human measured their responses. Acute deprivation causes anti-proliferative Warburg transcriptome, characterized ATF4-dependent signature. Iron-deprived show inhibition oxidative phosphorylation a concomitant increase glycolysis, large...
End-stage kidney disease (ESKD) patients are at high risk of severe COVID-19. We measured 436 circulating proteins in serial blood samples from hospitalised and non-hospitalised ESKD with COVID-19 (n = 256 55 patients). Comparison to 51 non-infected revealed 221 differentially expressed proteins, consistent results a separate subcohort 46 patients. Two hundred three were associated clinical severity, including IL6, markers monocyte recruitment (e.g. CCL2, CCL7), neutrophil activation...
Functional characterisation of cell-type-specific regulatory networks is key to establish a causal link between genetic variation and phenotype. The osteoclast offers unique model for interrogating the contribution co-regulated genes in vivo phenotype as its multinucleation resorption activities determine quantifiable skeletal traits. Here we took advantage trans-regulated gene network (MMnet, macrophage network) which found be significantly enriched GWAS variants associated with...
Abstract Macrophages undergo plasma membrane fusion and cell multinucleation to form multinucleated giant cells (MGCs) such as osteoclasts in bone, Langhans (LGCs) part of granulomas or foreign‐body (FBGCs) reaction exogenous material. How per se contributes functional specialization mature mononuclear macrophages remains poorly understood humans. Here, we integrate comparative transcriptomics with assays purified human osteoclasts, LGCs FBGCs. Strikingly, all three types MGCs, causes a...
Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine (bGH) transgenic mice to analyze the high serum levels BMD, architecture, mechanical Five-month-old hemizygous male bGH were compared age- sex-matched nontransgenic littermates controls (NT; n=16/group). Bone BMD analyzed in tibia lumbar vertebrae using...
Type 2 diabetes mellitus (T2DM) is associated with skeletal complications, including an increased risk of fractures. Reduced blood supply and bone strength may contribute to this fragility. We hypothesized that long-term administration Exenatide, a glucagon-like peptide-1 receptor agonist, would improve architecture T2DM mice by increasing flow bone, thereby stimulating formation. In study, we used model obesity severe T2DM, the leptin receptor-deficient db/db mouse assess alterations in...
Beyond the presence of insulin receptors, little is known mechanisms underlying biological effects in placenta. We show that phosphorylation MAPK and protein kinase B were enhanced 286 ± 23% 393 17% upon stimulation JAr placental cells. activation was prevented by pretreatment with PD98059 but unaffected wortmannin. Insulin abolished wortmannin, suggesting it dependent on phosphatidylinositol 3- activation. Despite phosphorylation, GLUT4 translocation, glucose uptake, glycogen synthesis not...
Niemann-Pick Disease, type C (NPC) is a fatal, neurodegenerative, lysosomal storage disorder. It rare disease with broad phenotypic spectrum and variable age of onset. These issues make it difficult to develop universally accepted clinical outcome measure assess urgently needed therapies. To this end, investigators have defined emerging, severity scales. The average time from initial symptom diagnosis approximately 4 years. Further, some patients may not travel specialized centers even after...
Abstract End-stage kidney disease (ESKD) patients are at high risk of severe COVID-19. We measured 436 circulating proteins in serial blood samples from hospitalised and non-hospitalised ESKD with COVID-19 (n=256 55 patients). Comparison to 51 non-infected revealed 221 differentially expressed proteins, consistent results a separate subcohort 46 patients. 203 were associated clinical severity, including IL6, markers monocyte recruitment (e.g. CCL2, CCL7), neutrophil activation proteinase-3)...
Abstract Functional characterisation of cell-type specific regulatory networks is key to establish a causal link between genetic variation and phenotype. The osteoclast offers unique model for interrogating the contribution co-regulated genes in vivo phenotype as its multinucleation resorption activities determine quantifiable skeletal traits. Here we took advantage trans -regulated gene network (MMnet, macrophage network) which found be significantly enriched GWAS variants associated with...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Niemann-Pick Disease, type C (NPC) is a fatal, neurodegenerative, lysosomal storage disorder.It rare disease with broad phenotypic spectrum and variable age of onset.These issues make it difficult to develop universally accepted clinical outcome measure assess urgently needed therapies.To this end, investigators have defined emerging, severity scales.The average time from initial symptom diagnosis approximately 4 years.Further, some patients may not travel specialized centers even after...