Sébastien Lefebvre

ORCID: 0000-0003-0722-1853
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About
Contact & Profiles
Research Areas
  • Animal Ecology and Behavior Studies
  • Vitamin K Research Studies
  • Poisoning and overdose treatments
  • Pharmacogenetics and Drug Metabolism
  • Pesticide Exposure and Toxicity
  • Yersinia bacterium, plague, ectoparasites research
  • Plant chemical constituents analysis
  • Diet and metabolism studies
  • Culinary Culture and Tourism
  • Insect and Pesticide Research
  • Horticultural and Viticultural Research
  • Phytochemical compounds biological activities
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Plant and fungal interactions
  • Semantic Web and Ontologies
  • Vitamin C and Antioxidants Research
  • Agriculture Sustainability and Environmental Impact
  • Muscle metabolism and nutrition
  • Insect Pheromone Research and Control
  • French Urban and Social Studies
  • Hormonal Regulation and Hypertension
  • Agriculture and Rural Development Research
  • Zoonotic diseases and public health
  • Drug-Induced Adverse Reactions
  • Edible Oils Quality and Analysis

Gouvernance, Risque, Environnement, Développement
2015-2023

Institut de Sciences des Matériaux de Mulhouse
2023

Université Claude Bernard Lyon 1
2016-2022

VetAgro Sup
2016-2022

Département Santé Animale
2018-2022

Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean
2021

Université de Sherbrooke
2021

Groupe Up (France)
2019

Institut National de la Recherche Agronomique
2015

Centre Hospitalier Territorial de Nouvelle-Calédonie
2009

Leptospirosis, a bacterial zoonosis with worldwide distribution, represents major public health challenge. It is caused by the spirochete Leptospira, whose main reservoir in urban environments brown rat ( Rattus norvegicus ). Understanding transmission dynamics of this disease within population essential for controlling risk human infection. In study, an original capture method was used to analyze variations carriage and load according age two distinct populations rats, provide better...

10.1155/tbed/3451406 article EN cc-by Transboundary and Emerging Diseases 2025-01-01

Second-generation anticoagulant rodenticides (SGARs) have been used since the 1980s for pest management. They are highly efficient even in warfarin-resistant rodents. Nevertheless, because of their tissue persistence, nontarget poisoning by SGARs is commonly described wildlife. Due to this major problem, a new generation anticoagulants must be developed limit risk. This study proposes method developing revisiting old based on concept stereochemistry. Each current SGAR mixture diastereomers....

10.1124/dmd.116.073791 article EN Drug Metabolism and Disposition 2016-12-02

Vitamin K is crucial for many physiological processes such as coagulation, energy metabolism, and arterial calcification prevention due to its involvement in the activation of several vitamin K-dependent proteins. During this activation, converted into epoxide, which must be re-reduced by VKORC1 enzyme. Various mutations have been described humans. While these widely associated with anticoagulant resistance, their association a modification status enzyme efficiency has never considered....

10.3390/nu11092076 article EN Nutrients 2019-09-03

Anticoagulant rodenticides (ARs) are important tools for controlling rodent pests, but they also pose a health threat to non-target species. ARs one of the most common causes pet poisoning. However, exposure domestic animals subclinical doses is poorly documented. To study random dogs and cats ARs, feces from showing no clinical signs rodenticide poisoning were collected network French Belgian veterinarians. We analyzed fresh 304 289 by liquid chromatography-tandem mass spectrometry. This...

10.3389/ftox.2022.907892 article EN cc-by Frontiers in Toxicology 2022-05-11
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