A5075424317- Malaria Research and Control
- Mosquito-borne diseases and control
- Invertebrate Immune Response Mechanisms
- Genomics and Phylogenetic Studies
- HIV Research and Treatment
- vaccines and immunoinformatics approaches
- Complement system in diseases
- Molecular Biology Techniques and Applications
- Multiple Myeloma Research and Treatments
- Parasite Biology and Host Interactions
- Caveolin-1 and cellular processes
Instituut voor Tropische Geneeskunde
2019-2024
University of Antwerp
2022-2023
Research Institute for Tropical Medicine
2023
Antwerp Management School
2022
Abstract Pathogen genomic epidemiology has the potential to provide a deep understanding of population dynamics, facilitating strategic planning interventions, monitoring their impact, and enabling timely responses, thereby supporting control elimination efforts parasitic tropical diseases. Plasmodium vivax , responsible for most malaria cases outside Africa, shows high genetic diversity at level, driven by factors like sub‐patent infections, hidden reservoir hypnozoites, early transmission...
Malaria is caused by parasites of the genus
The Plasmodium vivax reticulocyte invasion process is still poorly understood, with only a few receptor-ligand interactions identified to date. Individuals the Southeast Asian ovalocytosis (SAO) phenotype have deletion in band 3 protein on surface of erythrocytes, and are reported lower incidence clinical P. malaria. Based this observation, has been put forward as receptor for invasion, although direct proof lacking. In study, we combined functional ex vivo assays transcriptome sequencing...
Abstract Plasmodium vivax parasites preferentially invade reticulocyte cells in a multistep process that is still poorly understood. In this study, we used ex vivo invasion assays and population genetic analyses to investigate the involvement of complement receptor 1 (CR1) P . invasion. First, observed reticulocytes was consistently reduced when CR1 surface expression through enzymatic cleavage, presence naturally low-CR1-expressing compared with high-CR1-expressing cells, addition soluble...
Abstract Background Whole-genome sequencing (WGS) is becoming an increasingly popular tool to study the population genetics and drug resistance of Plasmodium spp. However, predominance human DNA in a malaria patient blood sample requires time-consuming lab procedures filter out or enrich DNA. Here, we investigated potential adaptive sampling for while unenriched samples on minION device. Results To compare versus regular sequencing, dilution series consisting 0% up 100% P. falciparum was...
Abstract Background Plasmodium vivax is the second most important cause of human malaria worldwide, and accounts for majority cases in South America. A high-quality reference genome exists Papua Indonesia (PvP01) Thailand (PvW1), but lacking specifically America would be beneficial though, as P. a genetically diverse parasite with geographical clustering. Results This study presents new assembly American isolate, referred to PvPAM ( Peruvian AMazon). The was obtained from low input patient...
Pathogen genomic epidemiology has the potential to provide a deep understanding of population dynamics, facilitating strategic planning interventions, monitoring their impact, and enabling timely responses, thereby supporting control elimination efforts parasitic tropical diseases. Plasmodium vivax, responsible for most malaria cases outside Africa, shows high genetic diversity at level, driven by factors like sub-patent infections, hidden reservoir hypnozoites, early transmission...
Abstract Background Plasmodium vivax is the second most important cause of human malaria worldwide, and accounts for majority cases in South America. A high-quality reference genome exists Papua Indonesia (PvP01) Thailand (PvW1), but lacking specifically America would be beneficial though, as P. a genetically diverse parasite with geographical clustering. Results This study presents new assembly American isolate, referred to PvPAM. The was obtained from low input patient sample Peruvian...