A5004895996- Pancreatic function and diabetes
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Biochemical effects in animals
- Endoplasmic Reticulum Stress and Disease
- Pancreatitis Pathology and Treatment
- Dietary Effects on Health
- Microbial Metabolites in Food Biotechnology
- Birth, Development, and Health
- Sleep and Wakefulness Research
- Alcohol Consumption and Health Effects
- Phytochemical Studies and Bioactivities
- Pharmacological Effects of Natural Compounds
- Barrier Structure and Function Studies
- Nuts composition and effects
- Vitamin C and Antioxidants Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
Chiang Mai University
2016-2025
Chulabhorn Hospital
2022-2025
Aim To evaluate the renoprotective roles of dapagliflozin in prediabetic rats order to elucidate effects this sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor on renal complications associated with metabolic dysfunction diet‐induced obesity. Methods Obesity was induced by feeding a high‐fat diet (HFD) male Wistar for 16 weeks. HFD‐fed were treated (1 mg/kg/d) or metformin (30 oral gavage 4 weeks after insulin resistance had been established. The characteristics and function lipid...
Gentamicin is a commonly used aminoglycoside antibiotic. However, its therapeutic use limited by nephrotoxicity. The mechanisms of gentamicin-induced nephrotoxicity are principally from renal inflammation and oxidative stress. Since atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, exerts lipid-lowering effects, antioxidant, anti-inflammatory as well anti-apoptotic this study aimed to investigate the protective effects atorvastatin against Male Sprague Dawley rats...
With an increasing prevalence of obesity and metabolic syndrome, exploring the effects delineating mechanisms possible therapeutic agents are critical importance. We examined SGLT2 inhibitor-dapagliflozin on insulin resistance, hepatic gluconeogenesis, injury pancreatic ER stress in high-fat diet-induced obese rats.Male Wistar rats were fed with normal diet (ND) or for 16 weeks. Then given vehicle (HF) dapagliflozin (1 mg/kg/day; HFDapa) metformin (30 HFMet) another 4 weeks.We found that...
Chronic consumption of a high-fat diet induces obesity and impairs the ultra-structure organs tissues. We examined effect sodium-glucose cotransporter 2 (SGLT2) inhibitor-dapagliflozin on renal pancreatic injuries in obese condition. Rats were fed for 16 weeks to induce obesity. After that, dapagliflozin or vildagliptin, 1.0 3.0 mg/kg/day, respectively, was administered by oral gavage 4 weeks. The effects insulin resistance, kidney autophagy, oxidative stress, endoplasmic reticulum (ER)...
Obesity is a risk factor for chronic kidney disease. The expansion of adipose tissues in obesity induces insulin resistance and low-grade systemic inflammation, promoting damage. Our previous studies have demonstrated that agomelatine (AGOM) exerts renoprotective effects experimental models through various mechanisms, including the attenuation ER stress oxidative stress. This study aimed to further explore on renal signaling, necroptosis obese, insulin-resistant rats. was induced rats with...
Hyperglycemia-induced oxidative stress is usually found in diabetic condition. 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, statins, are widely used as cholesterol-lowering medication with several "pleiotropic" effects patients. This study aims to evaluate whether the protective of atorvastatin and insulin on renal function organic anion transporter 3 (Oat3) involve modulation pancreatic type 1 rats. Type diabetes was induced by intraperitoneal injection...
The kidneys release glucose into the systemic circulation through reabsorption and renal gluconeogenesis. Currently, significance of in pathological conditions has become a subject interest. We examined effect sodium-dependent cotransporter 2 inhibitor (SGLT2i) on gluconeogenic enzyme expression obese rats. Male Wistar rats (180–200 g) were fed either normal diet (ND, n = 6) or high-fat diet. At 16 weeks, after confirming degree intolerance, diet-fed randomly subdivided three groups (...
Obesity is acknowledged as being a world health problem and increases the risk of several chronic diseases including kidney disease. High‐fat diet consumption obesity‐related renal disease show close correlation with increased oxidative stress. Black rice bran extract, (BRE) Oryza sativa L. variety “Luem Pua” contains high anthocyanin content. This study evaluated effects an anthocyanin‐rich fraction from BRE on function stress in obese rats. Male Wistar rats were fed normal (ND) or high‐fat...
High-fat diet (HFD) consumption causes obesity and gut dysbiosis which induces kidney injury. It has been reported that prebiotics improve insulin sensitivity decelerate the progression of disease. This study investigates impact fructooligosaccharides (FOS) on renoprotection prevention intestinal barrier injury in obese rats.
Long-term use of a high-fat diet with high-fructose (HFF) intake could promote insulin resistance and induce lipid accumulation leading to kidney injury possibly via impairment the autophagy process enhancement inflammasome pathway. We investigated whether dapagliflozin as monotherapy or combined atorvastatin restore reduce activation associated induced by HFF consumption. Male Wistar rats were given an for 16 weeks then treated without 4 weeks. Impaired glucose tolerance, dyslipidemia,...