A5070490547- Occupational and environmental lung diseases
- Metal complexes synthesis and properties
- Pleural and Pulmonary Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Cancer Research and Treatments
- Organometallic Complex Synthesis and Catalysis
- Advanced biosensing and bioanalysis techniques
- Aluminum toxicity and tolerance in plants and animals
- DNA and Nucleic Acid Chemistry
- Pharmacology and Obesity Treatment
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Ferrocene Chemistry and Applications
- Ocular Surface and Contact Lens
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- Multiple Sclerosis Research Studies
- Colorectal Cancer Screening and Detection
- Ocular Infections and Treatments
Asbestos Diseases Research Institute
2020-2025
Concord Repatriation General Hospital
2022
Ionis Pharmaceuticals (United States)
2018-2022
The Ohio State University
2020
Augusta University
2020
Western Sydney University
2014-2018
Camden and Campbelltown Hospitals
2016-2018
Case Western Reserve University
2013
Alethia Biotherapeutics (Canada)
2005
University of Illinois Urbana-Champaign
1988-1990
Background The Regulatory T cell (Treg) lineage is defined by the transcription factor FOXP3, which controls immune-suppressive gene expression profiles. Tregs are often recruited in high frequencies to tumor microenvironment where they can suppress antitumor immunity. We hypothesized that pharmacological inhibition of FOXP3 systemically delivered, unformulated constrained ethyl-modified antisense oligonucleotides could modulate activity and augment immunity providing therapeutic benefit...
The United States Preventive Services Task Force recently recommended against routine prostate cancer screening, stating that the risks of screening outweigh benefits. We determined impact this recommendation on in a large health system.We obtained data all specific antigen tests performed at University Hospitals Case Medical Center and affiliated hospitals northeastern Ohio from January 2008 to December 2012. examined total number ordered with time adjusted for patient volume by fitting...
Abstract Background Finding effective and curative treatment for mesothelioma remains challenging. While the introduction of immunotherapy combinations using ipilimumab (anti-CTLA-4) nivolumab (anti-PD-1) have offered hope some patients, a large proportion cases, particularly epithelial subtype, minimal benefit from this. Methods Our study was inspired by results AdvanTG-105 phase I clinical trial, which showed partial response with anti-TIGIT/PD-1 in two epithelioid patients. Here, we...
Abstract Objective Single‐nucleotide polymorphisms (SNPs) in the SLC22A4 gene encoding organic cation transporter OCTN1 have been associated with rheumatoid arthritis (RA) Japanese population and Crohn's disease a Canadian cohort. The RA‐associated disease–associated SNPs include, respectively, an intronic variant (slc2F2) exonic (1672T). We used case–control approach to investigate prevalence of these variants RA cohort determine whether share susceptibility alleles. Methods Nine hundred...
The diagnosis of malignant pleural mesothelioma (MPM) can be difficult, in part due to the difficulty distinguishing between MPM and reactive mesothelial hyperplasia (RMH). tumor suppressor gene, CDKN2A, is frequently silenced by epigenetic mechanisms many cancers; case it mostly via genomic deletion. Co-deletion CDKN2A methylthioadenosine phosphorylase (MTAP) genes has been researched extensively discovered a highly specific characteristic MPM. Most studies have used FISH detect deletion...
Cisplatin has been widely used for the treatment of cancer and its antitumour activity is attributed to capacity form DNA adducts, predominantly at guanine residues, which impede cellular processes such as replication transcription. However, there are associated toxicity drug resistance issues plague use. This prompted development screening a range chemotherapeutic analogues towards improved efficacy. The biological properties three novel platinum-based compounds consisting varying...
Summary An experimental model of keratoconjunctivitis sicca ( kcs ) was produced by removing the lacrimal gland and third eyelid from left eye 6 cats. The right each cat intact used as a control. After 2 weeks, cats were euthanatized central portion upper both eyes excised. Histologic sections stained with either hematoxylin eosin or battery biotinylated lectins including concanavalin A cona ), soybean agglutinin sba wheat germ wga succinylated s-wga Ulex europaeus I uea Dolichos biflorus...
The anti-tumour activity of cisplatin is thought to be a result its capacity form DNA adducts which prevent cellular processes such as replication and transcription. These can effectively induce cancer cell death, however, there are range clinical side effects drug resistance issues associated with use. In this study, the biological properties three novel dinuclear platinum-based compounds (that contain alkane bridging linkers eight, ten twelve carbon atoms in length) were characterised...
Malignant pleural mesothelioma (MPM) is a deadly thoracic malignancy and existing treatment options are limited. Chemotherapy remains the most widely used first-line regimen for patients with unresectable MPM, but hampered by drug resistance issues. The current study demonstrated modest enhancement of MPM cell sensitivity to chemotherapy following microRNA (miRNA) transfection in lines, albeit not all tested miRNAs. This effect was more pronounced FAK (PND-1186) small molecule inhibitor...
Purpose: The counseling regarding the treatment option is an important objective in management of early stages breast cancer. In this study, we attempt to compare and analyze dosimetric aspects 3DRT over IMRT whole radiotherapy. Methods Materials: Both right left sided computed tomography simulations 14 women with stage cancer were used for our retrospective study 3DCRT IMRT. dose prescribed was 50 Gy 25 fractions PTV. PTV defined by adding unequal margins directional safety margin status...
Pleural mesothelioma (PM) is a highly aggressive, fast-growing asbestos-induced cancer with limited effective treatments. There has been interest in using naturally occurring anticancer agents derived from plant materials for the treatment of PM. However, it unclear if an aqueous extract Leptospermum polygalifolium (QV0) activity against Here we investigated anti-cancer properties QV0 and Defender® (QV0 dietary formula) vitro vivo, respectively. suppressed growth eight PM cell lines...
Malignant pleural mesothelioma (MPM) is an aggressive malignancy with limited effective treatment options. Focal adhesion kinase (FAK) inhibitors have been shown to efficiently suppress MPM cell growth initially, utility in the current clinical setting. In this study, we utilised a large collection of lines and tissue samples study role E-cadherin (CDH1) microRNA on efficacy FAK MPM. The immunohistochemistry (IHC) results showed that majority FFPE exhibited either absence of, or very low,...
Amide coupling reactions can be used to synthesize bispyridine-based ligands for use as bridging linkers in multinuclear platinum anticancer drugs. Isonicotinic acid, or its derivatives, are coupled variable length diaminoalkane chains under an inert atmosphere anhydrous DMF DMSO with the of a weak base, triethylamine, and agent, 1-propylphosphonic anhydride. The products precipitate from solution upon formation precipitated by addition water. If desired, further purified recrystallization...
Amide coupling reactions can be used to synthesize bispyridine-based ligands for use as bridging linkers in multinuclear platinum anticancer drugs. Isonicotinic acid, or its derivatives, are coupled variable length diaminoalkane chains under an inert atmosphere anhydrous DMF DMSO with the of a weak base, triethylamine, and agent, 1-propylphosphonic anhydride. The products precipitate from solution upon formation precipitated by addition water. If desired, further purified recrystallization...
Abstract Regulatory T cells (Treg) contribute to the progression of cancer through suppression specific anti-tumor effector immune responses. Therefore, inhibition Treg function is an attractive approach for immunotherapy. However, despite substantial effort, Tregs remains a challenge. Foxp3 Treg-specific transcription factor required their development and function. We employed next-generation antisense inhibitors (Gen 2.5 cEt-modified ASOs) selectively inhibit expression in mouse evaluated...
Abstract Colorectal cancer (CRC) is third deadliest in United States, only behind lung and prostate cancer. Myeloid cell involvement tumor development dichotomous. There evidence that they can be immunostimulatory suppressive as well immunosuppressive tumorigenic. These cells seem to play a crucial role angiogenesis & vasculogenesis. The functional fluidity driven by factors present the microenvironment (TME), which alter myeloid gene expression thus phenotype function. Broadly,...