A5053487113- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Advanced Neuroimaging Techniques and Applications
- Preterm Birth and Chorioamnionitis
- Neuroscience of respiration and sleep
- Cerebral Palsy and Movement Disorders
- Infant Nutrition and Health
- Fetal and Pediatric Neurological Disorders
- Retinopathy of Prematurity Studies
- Cardiovascular Conditions and Treatments
- Congenital Diaphragmatic Hernia Studies
- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Pregnancy and preeclampsia studies
- Chemokine receptors and signaling
- Language Development and Disorders
- Birth, Development, and Health
- Cancer, Hypoxia, and Metabolism
- Congenital Heart Disease Studies
- Neonatal and Maternal Infections
University of Oulu
2010-2022
Oulu University Hospital
2014-2022
This study investigated the association of prenatal and neonatal factors with cognitive outcomes in schoolchildren born very preterm without impairments at age nine.We recruited a prospective regional cohort 154 low gestational (VLGA) children <32 weeks 90 term-born comparison between November 1998 2002 Oulu University Hospital, Finland. Cognitive outcome was assessed using an inclusive neuropsychological test repertoire nine.The final group comprised 77 VLGA cerebral palsy or any impairment...
Rationale: Bronchopulmonary dysplasia increases the risk of disability in extremely preterm infants. Although pathophysiology remains uncertain, prior exposure to intermittent hypoxemia may play a role this relationship. Objectives: To determine association between prolonged episodes and severe bronchopulmonary dysplasia. Methods: A post hoc analysis infants Canadian Oxygen Trial who survived 36 weeks' postmenstrual age was performed. saturations <80% for ⩾1 minute proportion time per day...
We examined the long-term outcomes and safety of early intravenous paracetamol for ductus arteriosus closure at a corrected age two years.This was follow-up 2013-2014 randomised, double-blind Preterm Infant's Paracetamol Study Oulu University Hospital, Finland, which recruited 48 very preterm infants within 24 hours birth. They received or placebo four days. In 2015-2017, we followed up 44 (92%) years age. This included clinical neurodevelopmental assessments parental medical history...
Intraventricular hemorrhage (IVH) in very preterm infants is a common disease associated with long-term consequences. Risk factors of IVH remain to be further defined.To determine whether specific immunoproteins at birth predict the risk and their receptors are localized bleeding site.A prospective cohort consisted 163 born before 32 weeks gestation. Altogether 107 cord blood 12 cytokines from peripheral obtained 1 7 days after were analyzed. Serial brain ultrasounds assessed....
Fetal growth restriction is associated with short-term and long-term mortality morbidity. We hypothesized that adverse outcome in children fetal at primary school age fetoplacental circulatory abnormalities.Comprehensive ultrasonographic assessment of hemodynamics was performed 72 growth-restricted fetuses prenatally, data were collected. At the median 9 years, morbidity determined using medical charts questionnaires. The impact abnormal on significant developmental disorders or delay...
Objective. To investigate whether blood cytokines during the perinatal period predict risk of cerebral palsy (CP) in preterm infants.Methods. This prospective cohort study comprised 169 children born before 32 weeks gestation. Cord was drawn at birth, and 109 were analyzed using microarrays. Eleven further measured from both cord peripheral on days 1 7. Cerebral confirmed 5 years age.Results. diagnosed 19 children. Five clusters scored factor analysis. According to logistic regression...
Abstract Aim This study evaluated the role of preterm birth and fetal growth restriction on white matter maturation in schoolchildren without any severe neurodevelopmental impairment. Methods The group comprised 56 very children 21 term born between November 1998 2002 at Oulu University Hospital, Finland. mean gestational age was 28.7 (24.1–31.9) weeks. All underwent diffusion tensor imaging a 9.0 (8.6–9.6) years. Voxel‐wise statistical analyses data were carried out using tract‐based...
This Finnish study compared language and reading abilities between schoolchildren born at a very low gestational age (VLGA) of <32 weeks term analysed any associations antenatal neonatal risk factors skills in the VLGA group.We prospectively followed 76 children 50 when they reached mean 9.0 (8.1-10.0) years. They attended mainstream schools had no severe neurosensory disabilities. Receptive ability, rapid naming word were evaluated using standardised tests.Children group lower scores for...
Prematurity and hereditary factors predispose to cerebral palsy (CP). Previously, low cord blood levels of the anti-inflammatory chemokine CCL18 have been found be associated with risk CP in preterm children.To investigate association between single nucleotide polymorphisms (SNPs) susceptibility CP, as well SNPs CCL18.The original population comprised very-low-gestational-age (VLGA; <32 weeks) children from northern central Finland (25 cases, 195 controls). Five were genotyped examined for...
Abstract Aim Our aim was to study whether prematurity, associated with prenatal and neonatal risk factors, affects specific literacy skills among school children born at a very low gestational age (VLGA) of <32 weeks. Methods The group comprised 76 prospectively followed VLGA between November 1998 2002 Oulu University Hospital, Finland, 51 term controls. median the 29.0 (24.1‐31.9) All were examined 8.9 (8.0‐9.9) years in 2007 2011. Reading fluency, comprehension spelling evaluated using...
Very preterm birth can disturb brain maturation and subject these high-risk children to neurocognitive difficulties later.The aim of the study was evaluate impact prematurity on microstructure frontostriatal tracts in with no severe neurologic impairment, whether diffusion tensor imaging metrics correlate executive functioning.The prospective cohort comprised 54 very (mean gestational age 28.8 weeks) 20 age- gender-matched term children. None had impairment. The underwent neuropsychological...
Prematurity and perinatal risk factors may influence white matter microstructure. In turn, these maturational changes language development in this high-risk population of children.To evaluate differences the microstructure association tracts between preterm term children with appropriate growth those fetal restriction to study whether diffusion tensor metrics correlate abilities schoolchildren no severe neurological impairment.This prospectively followed 56 very (mean gestational age: 28.7...
<h3>Background</h3> Cerebral palsy (CP) is a nonprogressive motor impairment syndrome caused by damage in the developing brain and it reveals clustering to preterm infants. Recently, genetic factors have been suggested as risk modifiers for CP. However, individual genes causing predisposition CP are still poorly understood. Low cord blood levels of CCL18 found associate with Since gene restricted primates, may be considered candidate functionality human brain. <h3>Aims</h3> To investigate...