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Pui Wang

ORCID: 0000-0003-0745-1130
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A5057213660
Research Areas
  • Immunotherapy and Immune Responses
  • vaccines and immunoinformatics approaches
  • CAR-T cell therapy research
  • Cancer Immunotherapy and Biomarkers
  • Influenza Virus Research Studies
  • Respiratory viral infections research
  • SARS-CoV-2 and COVID-19 Research
  • Immune Response and Inflammation
  • Viral gastroenteritis research and epidemiology
  • Immune Cell Function and Interaction

University of Hong Kong
 2022-2025

HKU-Pasteur Research Pole
 2025

Chinese University of Hong Kong
 2024

 An intranasal influenza virus-vectored vaccine prevents SARS-CoV-2 replication in respiratory tissues of mice and hamsters
OPENALEX - Publications 
Shaofeng Deng Ying Liu Rachel Chun-Yee Tam Pin Chen Jinxia Zhang and 12 more Bobo Wing-Yee Mok Teng Long Anja Kukic Runhong Zhou Haoran Xu Wenjun Song Jasper Fuk‐Woo Chan Kelvin Kai‐Wang To Zhiwei Chen Kwok‐Yung Yuen Pui Wang Honglin Chen

Abstract Current available vaccines for COVID-19 are effective in reducing severe diseases and deaths caused by SARS-CoV-2 infection but less optimal preventing infection. Next-generation which able to induce mucosal immunity the upper respiratory prevent or reduce infections highly transmissible variants of urgently needed. We have developed an intranasal vaccine candidate based on a live attenuated influenza virus (LAIV) with deleted NS1 gene that encodes cell surface expression...

10.1038/s41467-023-37697-1 article EN cc-by Nature Communications 2023-04-12
 Intranasal influenza virus-vectored vaccine offers protection against clade 2.3.4.4b H5N1 infection in small animal models
OPENALEX - Publications 
Ying Liu Shaofeng Deng Shuang Ren Rachel Chun-Yee Tam Siwen Liu and 5 more Jinxia Zhang Kelvin Kai‐Wang To Kwok‐Yung Yuen Honglin Chen Pui Wang

10.1038/s41467-025-58504-z article EN cc-by-nc-nd Nature Communications 2025-04-01
 A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8+ T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

Abstract Memory T cells play a key role in immune protection against cancer. Vaccine-induced tissue-resident memory (TRM) the lung have been shown to protect metastasis. Identifying source of TRM can help improve strategies, preventing tumor Here, we found that prime-boost vaccination approach using intramuscular DNA vaccine priming, followed by intranasal live-attenuated influenza-vectored (LAIV) boosting induced higher frequencies CD8+ compared with other regimens. cells, but not...

10.1158/0008-5472.can-23-3257 article EN cc-by-nc-nd Cancer Research 2024-07-18
 Supplementary Figure 10 from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;p&gt;Kinetic changes of CD8+ T subclusters and other subpopulations in response to different immunization approaches&lt;/p&gt;

10.1158/0008-5472.27142770 preprint EN 2024-10-01
 Data from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;div&gt;Abstract&lt;p&gt;Memory T cells play a key role in immune protection against cancer. Vaccine-induced tissue-resident memory (T&lt;sub&gt;RM&lt;/sub&gt;) the lung have been shown to protect metastasis. Identifying source of T&lt;sub&gt;RM&lt;/sub&gt; can help improve strategies, preventing tumor Here, we found that prime-boost vaccination approach using intramuscular DNA vaccine priming, followed by intranasal live-attenuated influenza-vectored (LAIV) boosting induced higher...

10.1158/0008-5472.c.7474557 preprint EN 2024-10-01
 Supplementary Figure 8 from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;p&gt;Supplementary Figure 8&lt;/p&gt;

10.1158/0008-5472.27142746 preprint EN 2024-10-01
 Supplementary Figure 7 from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;p&gt;Characterization of circulating genes across tissues and vaccination groups&lt;/p&gt;

10.1158/0008-5472.27142749 preprint EN 2024-10-01
 Supplementary Figure 1 from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;p&gt;Gag mosaic expressing LAIV vaccine construction and characterization&lt;/p&gt;

10.1158/0008-5472.27142773 preprint EN 2024-10-01
 Supplementary Figure 9 from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;p&gt;Supplementary Figure 9&lt;/p&gt;

10.1158/0008-5472.27142743 preprint EN 2024-10-01
 Supplementary Figure 2 from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;p&gt;Enhanced memory T cell response by systematic prime-nasal booster immunization in lung&lt;/p&gt;

10.1158/0008-5472.27142764 preprint EN 2024-10-01
 Supplementary Figure 6 from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;p&gt;Supplementary Figure 6&lt;/p&gt;

10.1158/0008-5472.27142752 preprint EN 2024-10-01
 Supplementary Figure 3 from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;p&gt;Enhanced memory T cell response by systematic prime-nasal booster immunization in the spleen&lt;/p&gt;

10.1158/0008-5472.27142761 preprint EN 2024-10-01
 Supplementary Figure 11 from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;p&gt;Effect of CXCR3 ligand-receptor interaction on TCM cell recruitment at day 14 post booster immunization&lt;/p&gt;

10.1158/0008-5472.27142767 preprint EN 2024-10-01
 Supplementary Figure 5 from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;p&gt;Antigen non-specific T cell response induced by V1 vaccination at day 30 post different depletion&lt;/p&gt;

10.1158/0008-5472.27142755 preprint EN 2024-10-01
 Supplementary Figure 4 from A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8<sup>+</sup> T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
OPENALEX - Publications 
Haoran Xu Ming Yue Runhong Zhou Pui Wang Michael Yik-Chun Wong and 14 more Jinlin Wang Huarong Huang Bohao Chen Yufei Mo Rachel Chun-Yee Tam Biao Zhou Zhenglong Du Haode Huang Li Liu Zhiwu Tan Kwok‐Yung Yuen You‐Qiang Song Honglin Chen Zhiwei Chen

&lt;p&gt;Systematic prime-nasal booster immunization enhanced the protection against mesothelioma lung metastasis and confirmation of T-cell depletion in tumor challenge model&lt;/p&gt;

10.1158/0008-5472.27142758 preprint EN 2024-10-01
 An intranasal influenza virus-vectored vaccine blocks SARS-CoV-2 replication in respiratory tissues of mice and hamsters
OPENALEX - Publications 
Shaofeng Deng Ying Liu Rachel Tam Pin Chen Jinxia Zhang and 12 more Bobo Wing-Yee Mok Teng Long Anja Kukic Runhong Zhou Haoran Xu Wenjun Song Jasper Fuk‐Woo Chan Kelvin Kai‐Wang To Zhiwei Chen Pui Wang Kwok‐Yung Yuen Honglin Chen

Abstract We have developed an intranasal vaccine candidate based on a live attenuated influenza virus (LAIV) with deleted NS1 gene that encodes cell surface expression of the receptor-binding-domain (RBD) SARS-CoV-2 spike protein, designated DelNS1-RBD4N-DAF. Immune responses and protection against challenge following administration DelNS1-RBD4N-DAF vaccines were analyzed in mice compared intramuscular injection BioNTech BNT162b2 mRNA hamsters. LAIVs induced high levels neutralizing...

10.21203/rs.3.rs-1880060/v1 preprint EN cc-by Research Square (Research Square) 2022-07-26
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