A5078224814- Viral Infections and Vectors
- Mosquito-borne diseases and control
- interferon and immune responses
- Virology and Viral Diseases
- COVID-19 Impact on Reproduction
- Respiratory viral infections research
- Inflammasome and immune disorders
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Bacteriophages and microbial interactions
- Veterinary Equine Medical Research
- Veterinary Orthopedics and Neurology
- High Altitude and Hypoxia
- Intestinal and Peritoneal Adhesions
- Drug-Induced Adverse Reactions
- Osteoarthritis Treatment and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Aortic Thrombus and Embolism
- Flavonoids in Medical Research
- Growth Hormone and Insulin-like Growth Factors
- Retinal and Optic Conditions
- Oral microbiology and periodontitis research
- IL-33, ST2, and ILC Pathways
- Autoimmune and Inflammatory Disorders Research
- Biochemical and Structural Characterization
Washington University in St. Louis
2016-2023
Tennessee State University
2014
Patients with stimulator of interferon genes (STING)-associated vasculopathy onset in infancy (SAVI) develop systemic inflammation characterized by vasculopathy, interstitial lung disease, ulcerative skin lesions, and premature death. Autosomal dominant mutations STING are thought to trigger activation IRF3 subsequent up-regulation (IFN)-stimulated (ISGs) patients SAVI. We generated heterozygous N153S knock-in mice as a model These spontaneously developed within the lung, hypercytokinemia, T...
West Nile and Powassan viruses cause fetal demise in mice replicate human placental tissue.
A variety of human rheumatologic disease-causing mutations have recently been identified. Some these are found in viral nucleic acid-sensing proteins, but whether viruses can influence the onset or progression diseases is less well understood. One such autoinflammatory disease, called STING-associated vasculopathy with infancy (SAVI), affects children and leads to severe lung disease. We generated mice a SAVI-associated STING mutation infected them γHV68, common DNA virus that related...
Here, we report our studies of immune-mediated regulation Zika virus (ZIKV), herpes simplex 1 (HSV-1), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the human cornea. We find that ZIKV can be transmitted via corneal transplantation mice. However, explants, does not replicate efficiently SARS-CoV-2 at all. Additionally, demonstrate type III interferon (IFN-λ) its receptor (IFNλR1) are expressed epithelium. Treatment explants with IFN-λ, treatment mice IFN-λ eye...
STING gain-of-function causes autoimmunity and immunodeficiency in mice STING-associated vasculopathy with onset infancy (SAVI) humans. Here, we report that prevents development of lymph nodes Peyer's patches. We show the absence secondary lymphoid organs is associated diminished numbers innate cells (ILCs), including tissue inducer (LTi) cells. Although wild-type (WT) α4β7+ progenitors differentiate efficiently into LTi cells, do not. Furthermore, impairs all types ILCs. Patients mutations...
STING modulates immunity by responding to bacterial and endogenous cyclic dinucleotides (CDNs). Humans mice with gain-of-function mutations develop a syndrome known as STING-associated vasculopathy onset in infancy (SAVI), which is characterized inflammatory or fibrosing lung disease. We hypothesized that hyperresponsiveness of CDNs might explain autoinflammatory disease SAVI mice. report depletion gut microbes oral antibiotics (vancomycin, neomycin, ampicillin [VNA]) nearly eliminates mice,...
Lesions of the lateral trochlear ridge (LTR) distal femur were investigated in four pony or cross horses. The animals all geldings and six to 15 months age. bilateral three ponies unilateral one. Femoropatellar joint effusion lameness present two ponies; clinical signs absent others. proximal LTR was affected animals. radiographic appearance lesions a subchondral defect containing mineralised bodies. Arthroscopic postmortem examination findings included an osteochondral flap, fissured...
Autosomal dominant STAT1 mutations in humans have been associated with chronic mucocutaneous candidiasis (CMC), as well increased susceptibility to herpesvirus infections. Prior studies focused on mucosal and Th17-mediated immunity against Candida, but mechanisms of impaired antiviral not previously examined. To begin explore the STAT1-associated immunodeficiency herpesviruses, we generated heterozygous R274W knock-in mice that a frequently reported mutation In primary macrophages...