A5053149349- Child Abuse and Trauma
- Child and Adolescent Psychosocial and Emotional Development
- Early Childhood Education and Development
- Identity, Memory, and Therapy
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Maternal Mental Health During Pregnancy and Postpartum
- Posttraumatic Stress Disorder Research
- Cognitive Abilities and Testing
- Suicide and Self-Harm Studies
- Stress Responses and Cortisol
- Psychosomatic Disorders and Their Treatments
- Attachment and Relationship Dynamics
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Death Anxiety and Social Exclusion
- Deception detection and forensic psychology
- Child Welfare and Adoption
- Schizophrenia research and treatment
- Resilience and Mental Health
- Neuroendocrine regulation and behavior
- Infant Development and Preterm Care
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
University College London
2014-2024
Anna Freud Centre
2016-2024
Language Science (South Korea)
2018
Universitätsklinikum Aachen
2014
Early-life adversity (ELA) is one of the major risk factors for serious mental and physical health risks later in life. ELA has been associated with dysfunctional neurodevelopment, especially brain structures such as hippocampus, dysfunction stress system, including hypothalamic-pituitary-adrenal (HPA) axis. Children who have experienced are also more likely to suffer from disorders depression The exact interplay aberrant neurodevelopment HPA axis psychopathology not yet clear. We...
Abstract Cognitive control is required to organize thoughts and actions critical for the pursuit of long-term goals. Childhood cognitive relates other domains functioning predicts later-life success well-being. In this study, we used a randomized controlled trial test whether can be improved through pre-registered 8-week intervention in 235 children aged 6–13 years targeting response inhibition leads changes multiple behavioral neural outcomes compared speed training. We show long-lasting...
Childhood maltreatment is associated with alterations in neural architecture that potentially put these children at increased risk for psychopathology. Alterations white matter (WM) tracts have been reported, however no study to date has investigated WM connectivity brain networks maltreated quantify global and local abnormalities through graph theoretical analyses of DTI data. We aimed a multilevel investigation examining the DTI-based structural connectome its associations basal cortisol...
Children exposed to maltreatment show neural sensitivity facial cues signalling threat. However, little is known about how influences the processing of social threat more broadly, and whether atypical relates psychiatric risk.Forty-one 10- 14-year-old children underwent a rejection-themed emotional Stroop task during functional magnetic resonance imaging: 21 with documented history (11 F) 19 comparison no F). Groups were matched on age, pubertal status, gender, IQ, socioeconomic ethnicity...
Background Altered autobiographical memory (ABM) functioning has been implicated in the pathogenesis of depression and posttraumatic stress disorder may represent one mechanism by which childhood maltreatment elevates psychiatric risk. Aims To investigate impact on ABM functioning. Method Thirty-four children with documented 33 matched controls recalled specific ABMs response to emotionally valenced cue words during functional magnetic resonance imaging. Results Children experience showed...
Alterations in reinforcement-based decision making may be associated with increased psychiatric vulnerability children who have experienced maltreatment. A probabilistic passive avoidance task and a model-based functional magnetic resonance imaging analytic approach were implemented to assess the neurocomputational components underlying making: (a) reinforcement expectancies (the representation of outcomes stimulus) (b) prediction error signaling ability detect differences between expected...
Abstract While maltreatment is known to impact social and emotional functioning, threat processing, neural structure, the potentially dimorphic influence of sex on these outcomes remains relatively understudied. We investigated differences across domains in a large community sample children aged 10 14 years ( n = 122) comprising 62 with verified experience 60 well-matched nonmaltreated peers. The maltreated group relative comparison exhibited poorer functioning (more peer problems heightened...
Abstract Background Childhood maltreatment is robustly associated with increased risk of poor mental health outcome and changes in brain function. The authors investigated whether childhood experience abuse (e.g. physical, emotional sexual abuse) neglect (physical deprivation) was differentially neural reactivity to threat. Methods Participants were drawn from an existing study allocated one four groups based on self-report experience: individuals experiences ( n = 70); 87); combined 50);...
Childhood maltreatment is one of the most potent predictors future psychopathology, including internalizing disorders. It remains unclear whether heightened amygdala reactivity to threat and elevated stress exposure may be implicated in pathogenesis maintenance disorders among individuals with a history childhood maltreatment.
ObjectiveChildhood maltreatment has been associated with major depressive disorder (MDD). Atypical self-generated thoughts (SGT), lacking in positive and privileging negative content—a feature of ruminative thinking—might represent one vulnerability factor for developing depression. Rumination MDD linked to alterations resting-state functional connectivity (RSFC) the subgenual anterior cingulate cortex (sgACC) default mode network fronto-parietal (FPN). This study aimed investigate online...
An extensive literature has detailed how maltreatment experience impacts brain structure in children and adolescents. However, there is a dearth of studies on the influence surface based indices, to date no study investigated sex influences impact cortical thickness, area local gyrification. We differences these measures large community sample aged 10–14 years (n = 122) comprising 62 with verified 60 matched non-maltreated controls. The maltreated group relative controls presented pattern...
Maltreatment is associated with increased risk of a range psychiatric disorders, many which are characterized by altered risk-taking propensity. Currently, little known about the neural correlates in children exposed to maltreatment, nor whether their atypically modulated peer influence. Seventy-five 10- 14-year-old [maltreated (MT) group: N = 41; non-maltreated Group (NMT): 34] performed Balloon Analogue Risk Task (BART), under three different influence conditions: while alone, being...
It has been debated whether children who have experienced early life stress (ELS), such as caregiver separation show elevated risk for stress-related psychiatric disorders and a multi-symptom psychopathological profile that is not fully reflected in categorical assessments. In this study, we investigated dimensional measures of psychopathology permanent out-of-home care, taking into account potential neuroendocrine interactions. the current 25 had placed care before age 3 (years) 26 controls...
Abstract Objectives Childhood maltreatment is associated with altered neural reactivity during autobiographical memory (ABM) recall and a pattern of overgeneral (OGM). Altered ABM OGM have been linked psychopathology poorer social functioning. The present study investigated the association between subsequent socio-emotional functioning (measured two years later) in sample adolescents ( N = 20; group, MT) without 17; non-MT group) documented childhood histories. Method At baseline, (aged 12.6...
Previous studies have shown that the experience of childhood maltreatment can influence recognition and processing emotional cues these effects extend into adulthood. Such alterations in cognitive may important implications for infant affect parenting behavior. This study investigated whether altered attentional faces a community sample mothers, using an established visual search task. Increased scores on measure were associated with decreased preferential bias toward (indexed by slower...
Abstract Altered autobiographical memory (ABM) processing characterizes some individuals with experiences of childhood maltreatment. This fMRI study ABM evaluated potential developmental plasticity in neural functioning following Adolescents ( N = 19; MT group) and without 18; Non-MT documented maltreatment recalled specific ABMs response to emotionally valenced cue words during at baseline (age 12.71 ± 1.48) follow-up (14.88 1.53 years). Psychological assessments were collected both...
Objectives: Although clear advances have been achieved in the study of early-onset schizophrenia (EOS), little is known to date about premorbid and prodromal neuropsychological functioning EOS. Method: Here, we report on a case an adolescent male with EOS who underwent testing before after illness onset. Results: Marked cognitive deficits domains attention, set-shifting, verbal memory were present both pre-onset during course schizophrenia, though only persisted illness-onset antipsychotic...
Childhood maltreatment is associated with altered neurocognitive functioning, which thought to reflect, in part, adaptation early adverse environmental experiences. However, we continue lack a precise mechanistic understanding linking atypical processing social functioning and psychiatric outcomes following adversity.