A5064503406- Parathyroid Disorders and Treatments
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Magnesium in Health and Disease
- Acute Kidney Injury Research
- Trace Elements in Health
- Renal and related cancers
- Neurological and metabolic disorders
- Phagocytosis and Immune Regulation
- Pancreatitis Pathology and Treatment
- Nuclear Receptors and Signaling
- Cytokine Signaling Pathways and Interactions
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Biomedical Research and Pathophysiology
- Chronic Kidney Disease and Diabetes
- Mitochondrial Function and Pathology
- Inflammasome and immune disorders
- Arsenic contamination and mitigation
- Pancreatic and Hepatic Oncology Research
- Metabolism and Genetic Disorders
- Endoplasmic Reticulum Stress and Disease
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Cardiac electrophysiology and arrhythmias
Hospital Universitario 12 De Octubre
2020-2025
Research Institute Hospital 12 de Octubre
2024
Hospital Universitario Fundación Jiménez Díaz
2011-2018
Spanish Clinical Research Network
2014-2018
Universidad Autónoma de Madrid
1996-2018
Fundación Renal
2011-2017
Pediatric Nephrology of Alabama
2016
Hospital Universitario de La Princesa
2002
AKI is histologically characterized by necrotic cell death and inflammation. Diverse pathways of regulated necrosis have been reported to contribute AKI, but the molecular regulators involved remain unclear. We explored relative contributions ferroptosis necroptosis folic acid (FA)-induced in mice. FA-AKI mice associates with lipid peroxidation downregulation glutathione metabolism proteins, features that are typical ferroptotic death. show ferrostatin-1 (Fer-1), an inhibitor ferroptosis,...
Tenofovir is an acyclic nucleotide analogue reverse-transcriptase inhibitor structurally similar to the nephrotoxic drugs adefovir and cidofovir. widely used treat HIV infection approved for treatment of hepatitis B virus. Despite initial cell culture clinical trials results supporting renal safety tenofovir, its use associated with a low, albeit significant, risk kidney injury. Proximal tubular secretion tenofovir explains accumulation drug in these mitochondria-rich cells. nephrotoxicity...
Abstract Ischaemic heart disease (IHD) remains a major cause of death and morbidity. Klotho is well‐known anti‐ageing factor with relevant cardioprotective actions, at least when renal dysfunction present, but its actions are much less known function preserved. This study investigated as biomarker potential novel treatment IHD‐associated complications after myocardial infarction (MI) under preserved function. Association between circulating levels cardiac injury was in patients ST‐elevation...
Backgroundp-Cresyl sulphate (p-CS) and p-cresyl glucuronide (p-CG) are uraemic toxins that exhibit pro-inflammatory features in leukocytes associated with the progression of chronic kidney disease (CKD). Tubular cells key targets nephrotoxic agents tubular cell death activation contribute to CKD. However, potential toxicity these compounds on is not fully understood. More specifically, apoptosis has never been studied.
Abstract Current therapy for chronic kidney disease ( CKD ) is unsatisfactory because of an insufficient understanding its pathogenesis. Matrix remodelling‐associated protein 5 MXRA 5, adlican) a human unknown function with high tissue expression, not present in rodents. Given the increased expression injured tissues, including kidneys, we have suggested that may modulate injury. immunoreactivity was observed tubular cells renal biopsies and urine from patients. We then explored factors...
Acute kidney injury (AKI) is characterized by tubular cell death and interstitial inflammation. TWEAK promotes experimental activates the transcription factor NF-κB, a key regulator of genes involved in survival inflammatory response. In search potential therapeutic targets for AKI, we compared transcriptomics database NF-κB-related from murine AKI-kidneys with TWEAK-stimulated cultured cells. Four out twenty-four (17%) were significantly upregulated (false discovery rate, FDR<0.05), while...
The term acute tubular necrosis was thought to represent a misnomer derived from morphological studies of human necropsies and an unregulated passive form cell death which not amenable therapeutic manipulation. Recent advances have improved our understanding in kidney injury. First, apoptosis results loss, but does trigger inflammatory response. However, clumsy attempts at interfering with (e.g. certain caspase inhibitors) may and, thus, inflammation-mediated Second, most revolutionary, the...
Abstract Albuminuria promotes tubular injury and cell death, is associated with faster progression of chronic kidney disease (CKD) to end-stage renal disease. However, the molecular mechanisms regulating death in response albuminuria are not fully understood. Brain abundant signal protein 1 (BASP1) was recently shown mediate glucose-induced apoptosis cells. We have studied role BASP1 albumin-induced death. expression experimental puromycin aminonucleoside-induced nephrotic syndrome rats...
Preclinical studies suggest that Gremlin participates in renal damage and could be a potential therapeutic target for human chronic kidney diseases. Inflammation is common characteristic of progressive disease, therefore novel anti-inflammatory targets should investigated. The Notch signaling pathway involved development activated but whether regulates the has not been In cultured tubular cells, up-regulated gene expression several components, increased production canonical ligand Jagged-1,...
The Notch pathway regulates key processes in the kidney involved embryonic development and tissue damage. Local activation of has been described many human chronic renal diseases, suggested that several components could be considered as biomarkers Experimental studies done using Notch-components genetic modified mice well pharmacological approaches, such γ-secretase inhibitors block activation, have demonstrated role this regeneration, podocyte apoptosis, proliferation fibroblasts induction...
Oxidized low-density lipoprotein (oxLDL) is associated with cardiac damage and causes injury to multiple cell types. We aimed investigate the role of oxLDL in ventricular stress. first examined association between circulating N-terminal pro-brain natriuretic peptide (NT-proBNP), a marker myocardial stress, young subjects (30–50 years) or without stable coronary artery disease (SCAD). NT-proBNP were significantly higher at high cardiovascular risk (CVR) than low CVR independently traditional...