A5033922813- Parathyroid Disorders and Treatments
- Cardiac electrophysiology and arrhythmias
- Magnesium in Health and Disease
- Endoplasmic Reticulum Stress and Disease
- Neurological and metabolic disorders
- Chronic Kidney Disease and Diabetes
- Cardiovascular Effects of Exercise
- Vitamin D Research Studies
- Inflammasome and immune disorders
- Muscle and Compartmental Disorders
- Cardiac Health and Mental Health
- Pancreatitis Pathology and Treatment
- Cardiovascular Function and Risk Factors
- Medical Imaging and Pathology Studies
- Pulmonary Hypertension Research and Treatments
- Connective tissue disorders research
- Receptor Mechanisms and Signaling
- Genetic Syndromes and Imprinting
- GDF15 and Related Biomarkers
- Cardiomyopathy and Myosin Studies
- Acute Kidney Injury Research
- NF-κB Signaling Pathways
- Biomedical Research and Pathophysiology
- Cell death mechanisms and regulation
Hospital Universitario 12 De Octubre
2020-2025
Research Institute Hospital 12 de Octubre
2024
Abstract Ischaemic heart disease (IHD) remains a major cause of death and morbidity. Klotho is well‐known anti‐ageing factor with relevant cardioprotective actions, at least when renal dysfunction present, but its actions are much less known function preserved. This study investigated as biomarker potential novel treatment IHD‐associated complications after myocardial infarction (MI) under preserved function. Association between circulating levels cardiac injury was in patients ST‐elevation...
Oxidized low-density lipoprotein (oxLDL) is associated with cardiac damage and causes injury to multiple cell types. We aimed investigate the role of oxLDL in ventricular stress. first examined association between circulating N-terminal pro-brain natriuretic peptide (NT-proBNP), a marker myocardial stress, young subjects (30–50 years) or without stable coronary artery disease (SCAD). NT-proBNP were significantly higher at high cardiovascular risk (CVR) than low CVR independently traditional...
Acute kidney injury (AKI) is associated with an elevated risk of cardiovascular major events and mortality. The pathophysiological mechanisms underlying the complex cardiorenal network interaction remain unresolved. It known that presence AKI its evolution are significantly alteration in anti-aging factor klotho expression. However, it unknown whether a deficiency might aggravate cardiac damage after AKI. We examined intracellular calcium (Ca2+) handling native ventricular isolated...
Background: Ischemic heart disease (IHD) remains a major cause of death and morbidity. New drugs are needed to treat IHD following myocardial infarction (MI). This study investigates Klotho as biomarker potential novel treatment IHD-associated complications after MI under preserved renal function.Methods: Association between circulating levels cardiac injury were investigated in patients ST-elevation (STEMI). Biochemical, vivo vitro function, histological molecular studies performed analyze...
Antecedentes y objetivo: En un fracaso renal agudo (FRA) se activa fuerte componente inflamatorio como respuesta al daño renal, uno de los principales mediadores este proceso es la interleuquina pro-inflamatoria 6 o IL-6. A su vez, ligado a fenómeno también producen alteraciones en distintos componentes del metabolismo mineral son aquellos dependientes factor crecimiento fibroblasto (FGF)23 el cofactor anti-envejecimiento klotho. El objetivo trabajo fue explorar asociación entre función...
Objective: Cardiorenal Syndrome type IV (CRS-IV) is a common complication of chronic kidney disease (CKD) and high-risk syndrome with poor prognosis. However, pathogenic mechanisms remain elusive. Our objective was to characterize early cardiac structural, functional, molecular alterations in Munich Wistar Frömter (MWF), rat model established CKD. Design method: Cardiac function, rhythm structure were analyzed aging 22- 45-week-old MWF rats (n=8/group) by electrocardiogram (ECG) magnetic...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): ISCIII, Ministerio de Universidades, Education and Research Council Madrid, Biomedicine Network Comunidad Madrid Background Acute kidney injury (AKI) is usually associated with an acute cardiac impairment known as cardiorenal syndrome type 3 (CRS3). AKI induces the activation immune system being connection disturbance in remote organs heart. In response to tissue damage,...
In acute kidney injury (AKI), a strong inflammatory component is activated in response to the renal damage, and one of main mediators behind this process pro-inflammatory interleukin 6 or IL-6. Beside phenomenon, there are also alterations different components mineral metabolism, such as those dependent on fibroblast growth factor (FGF)23 anti-ageing cofactor klotho. The aim work was explore association between function systemic levels IL-6, well FGF23 klotho early stages AKI, analysing...
Abstract Heart and kidney have a closely interrelated pathophysiology. Acute injury (AKI) is associated with significantly increased rates of cardiovascular events, relationship defined as cardiorenal syndrome type 3 (CRS3). The underlying mechanisms that trigger heart disease remain, however, unknown, particularly concerning the clinical impact AKI on cardiac outcomes overall mortality. Tumour necrosis factor‐like weak inducer apoptosis (TWEAK) its receptor fibroblast growth...