A5031188583- Sleep and related disorders
- Sleep and Wakefulness Research
- Workplace Health and Well-being
- Sleep and Work-Related Fatigue
- Circadian rhythm and melatonin
- Employment and Welfare Studies
- Youth Substance Use and School Attendance
- Resilience and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- Intensive Care Unit Cognitive Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Anesthesia and Neurotoxicity Research
- Child Abuse and Trauma
- COVID-19 and Mental Health
- Physical Activity and Health
- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Neuroscience and Neural Engineering
- Job Satisfaction and Organizational Behavior
- Eating Disorders and Behaviors
- Maternal Mental Health During Pregnancy and Postpartum
- Balance, Gait, and Falls Prevention
- Stress and Burnout Research
Stanford University
2024-2025
Tokyo Medical University
2014-2024
Tokyo Institute of Psychiatry
2022
In-Q-Tel
2022
Introduction: Remote work was widely promoted in 2020, as a result of the COVID-19 pandemic. However, effects remote on psychological and physical stress responses presenteeism workers remain unclear. This research aims to provide empirical evidence implications for people organizations this new scenario working from home. Methods: A two-wave panel survey before after pandemic performed investigate these aspects among office workers. total 3,123 23 tertiary industries responded...
Sleep affects adolescents in various ways. However, the effects of multiple factors on sleep hygiene remain unclear. A comprehensive assessment life habits high-school students was conducted.A cross-sectional survey 344 high school (age range 15-17; 171 boys, 173 girls) Tokyo, Japan conducted 2015. Complete responses were provided by 294 students. Demographic variables, Pittsburgh Quality Index (PSQI), diurnal type scale, Pediatric Daytime Sleepiness Scale (PDSS), and such as dinnertime,...
Occupational mental health, work environment, sleep presenteeism, and loss of productivity caused by health problems are all public concerns. Although affects the associations between disturbance, job stressors, stress responses, presenteeism have remained unclear. We hypothesized that stressors affect office workers through disturbance analyzed association among these factors.In 2017, a cross-sectional survey adult was performed. A total 2899 subjects who provided written consent were...
There is a lack of evidence regarding answers for clinical questions about treating insomnia disorder. This study aimed to answer the following questions: (1) how use each hypnotic and non-pharmacological treatment differently depending on situations (2) reduce or stop benzodiazepine hypnotics using alternative pharmacological treatments.Experts were asked evaluate choices based 10 disorder nine-point Likert scale (1 = "disagree" 9 "agree"). The responses 196 experts collected, categorized...
Although physical activity and exercise are generally thought to have favorable effects on mental health, excessive may unfavorable effects. In this study, the associations between states of health with U-shaped dose-response curves were hypothesized, ranges resulting in optimal investigated.A cross-sectional survey was conducted 1,237 adult volunteers 2017 2018. Of these volunteers, 526 participants validly answered self-administered questionnaires asking about activity, depression,...
Presenteeism has attracted much attention in the research into mental health. However, how cognitive complaints and depressive symptoms affect presenteeism remains unknown. Therefore, this study examined correlation between subjective impairment, symptoms, work limitations.We collected data from 477 adult workers Japan. We evaluated function using Cognitive Complaints Bipolar Disorder Rating Assessment (COBRA), with Patient Health Questionnaire 9 (PHQ-9), limitations Work Limitations 8...
Postoperative delirium (POD) is a severe neuropsychiatric state characterized by acute fluctuating various mental symptoms. Despite its prevalence, the underlying mechanisms of POD remain largely unknown, and effective biomarkers for detection are lacking. We have successfully developed novel method, bispectral electroencephalography (BSEEG) which has shown excellent performance in outcome prediction. From there, similar to clinical situation, we hypothesize that BSEEG scores can serve as...
Post-operative delirium (POD) is a common complication after surgery especially in elderly patients, characterized by acute disturbances consciousness and cognition, which negatively impacts long-term outcomes. Effective treatments remain elusive due to the unclear pathophysiology of POD. To address knowledge gap, we investigated DNA methylation profiles gene expression changes brain cells from POD non-POD patients who underwent resection for medication refractory epilepsy. analysis revealed...
Introduction: Interleukin-11 (IL-11) is a cytokine involved in inflammatory processes and previous study showed that blocking or knocking down IL11 mice prolongs healthy lifespan. This investigates DNA methylation (DNAm) changes the IL-11 receptor subunit alpha (IL-11RA) gene across ages to reveal how aging might influence production sensitivity. Methods: A genome-wide DNAm database focusing on Cytosine-phosphate-Guanine (CpG) sites within IL11RA was analyzed. Hierarchical regression...
Recent studies have suggested that the interactions among several factors affect onset, progression, and prognosis of major depressive disorder. This study investigated how childhood abuse, neuroticism, adult stressful life events interact with one another symptoms in general population.A total 413 participants from nonclinical population completed Patient Health Questionnaire-9, Child Abuse Trauma Scale, neuroticism subscale shortened Eysenck Personality Questionnaire - Revised, Life...
The aim of this study was to examine the risk falls associated with use non-gamma amino butyric acid (GABA) sleep medications, suvorexant and ramelteon. This case-control case-crossover performed at Kudanzaka Hospital, Chiyoda Ward, Tokyo. A total 325 patients who had 1295 controls matched by sex age were included. inclusion criteria for case group hospitalized their first fall that control did not have a fall, between January 2016 November 2018. internal medications administered classified...
The aim of this study was to investigate the impact sleep problems on job stress in office workers.This included 4645 workers from 29 companies who completed questionnaires between April 2017 and 2019 Japan. Sleep duration assessed based participants' subjective schedule workdays free days. midpoint days (sleep-corrected) social jetlag were calculated accordance with Munich Chronotype Questionnaire. To assess stress, we used 57-item Brief Job Stress Questionnaire.Multivariate logistic...
Long working hours are detrimental to physical and mental health. However, the association between long psychosomatic symptoms have remained controversial, possibly because of existence mediators stress responses. We hypothesized that lifestyle habits, regarding sleep mealtimes, act as mediators, analyzed associations hours, duration, mealtime regularity, responses in office workers.From April 2017 March 2018, an online cross-sectional survey overtime work work-related stress, sleep, eating...
Objectives: Social jetlag (SJL), the discrepancy between an individual's inherent circadian rhythm and external social schedule, is associated with obesity. This study aimed to investigate whether SJL also influences body weight fat loss during dieting. Methods: was observational from 2015 2018 participants who had joined exercise nutrition program at a private personal training gym. Data 11,829 individuals provided by gym along their sleep logs were analyzed. Differences in change mass...
Delirium is a multifactorial medical condition characterized by impairment across various mental functions and one of the greatest risk factors for prolonged hospitalization, morbidity, mortality. Research focused on delirium has proven to be challenging due lack objective measures diagnosing patients, few laboratory models have been validated. Our recent studies report efficacy bispectral electroencephalography (BSEEG) in patients predicting patient outcomes. We applied BSEEG validate...
Previous studies have reported that physical activity can prevent the onset of depression and reduces anxiety. In present study, hypothesis total time influences depressive symptoms via state trait anxiety was tested by a path analysis. Self-administered questionnaires were used to survey 526 general adult volunteers from April 2017 2018. Demographic information, activity, investigated. The association between expressed as U-shape curve. results covariance structure analysis showed...
The complex interaction between parenting styles, job stressors, and the stress response has not been clarified to date. We hypothesized that neuroticism acts as a mediator in effects of quality on perceived stressors psychological physical (PPSR), tested this hypothesis using covariance structure analysis.We conducted research April 2017 2018 597 adult from community, 69 subjects were excluded owing missing data or nonworkers. Finally, total 528 participants analyzed following...
Background: Personality traits, such as neuroticism, that results in vulnerability to stress, and resilience, a measure of stress coping, are closely associated with the onset depressive symptoms, whereas regular physical activity habits have been shown reduce symptoms. In this study, mediating effects neuroticism resilience between duration symptoms were investigated by covariance structure analysis. Methods: Between April 2017 2018, 526 adult volunteers surveyed using self-administered...