A5040597512- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Esophageal and GI Pathology
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Pancreatic function and diabetes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- IgG4-Related and Inflammatory Diseases
- Hip disorders and treatments
- Tissue Engineering and Regenerative Medicine
- Biliary and Gastrointestinal Fistulas
- Total Knee Arthroplasty Outcomes
- Gastrointestinal Tumor Research and Treatment
- Hip and Femur Fractures
- Xenotransplantation and immune response
- Knee injuries and reconstruction techniques
- Helicobacter pylori-related gastroenterology studies
- Soft tissue tumor case studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Genetic and Kidney Cyst Diseases
Sapporo Medical University
2013-2024
Sendai Medical Center
2017-2023
Kushiro City General Hospital
2018-2020
Okayama University
2019
Takatsuki General Hospital
2018
Foundation for Biomedical Research and Innovation
2018
Kobe University
2000-2015
Shinshu University
2000-2011
Eisai (Japan)
2009
Ritsumeikan University
2008
omega-Agatoxin-TK (omega-Aga-TK), a 48-amino-acid peptide isolated from the venom of funnel web spider (Agelenopsis aperta), is selective and potent inhibitor P-type calcium channels in nervous system. We have synthesized that has amino acid sequence identified for native omega-Aga-TK. The synthetic omega-Aga-TK, however, showed 80-90-fold less inhibition channels, compared with Enantiomer analysis omega-Aga-TK revealed D-serine at position 46, omega-[D-Ser46]Aga-TK had same potency as...
In the treatment of diffuse panbronchiolitis, azithromycin (AZM), a new macrolide antibiotic with 15-membred lactone ring, was studied for its efficacy and safety.AZM, 250 mg, intermittently administered to total 60 patients twice weeks, 3 months as rule, clinically evaluated in 52 safety 55.The rate 84.6%(44/52). Clinical findings 12 weeks after start administration showed decrease sputum volume 30 46 amelioration dyspnea on exertion 23 patients, no worsening symptoms observed patients....
In this study, we aimed to evaluate the predictive value of localized stenosis main pancreatic duct (MPD) for early detection cancer.Among 689 patients who underwent endoscopic retrograde pancreatography from January 2008 September 2018, 19 with MPD findings were enrolled. These showed indicating suspicious cancer at an stage (FiCE); FiCE was defined as a single, in without detectable mass (using any other imaging methods) and diseases, such definite chronic pancreatitis, intraductal...
Abstract Background and study aims A newly developed peroral cholangioscopy (POCS) system, SpyGlassDS has high maneuverability. This aimed to evaluate acceptability of the accuracy accompanied by simultaneous POCS-guided biopsy compared with that a traditional POCS scope, CHF-B260, diagnose lateral extent extrahepatic cholangiocarcinoma (LEC). Patients methods who underwent surgical resection after preoperative examinations LEC were evaluated. CHF-B260 was performed if there discrepancy...
It is often difficult to manage acute cholecystitis after metal stent (MS) placement in unresectable malignant biliary strictures. The aim of this study was evaluate the feasibility endoscopic ultrasonography-guided gallbladder drainage (EUS-GBD) for cholecystitis.The clinical outcomes 10 patients who underwent EUS-GBD MS between January 2011 and August 2018 were retrospectively evaluated. procedural percutaneous transhepatic (PTGBD) with tube (n=11 cases) aspiration (PTGBA) (n=27 during...
This study aimed to identify the predictive factors for inaccurate endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) diagnosis of swollen lymph nodes without rapid on-site cytopathological evaluation.Eighty-three consecutive patients who underwent EUS-FNA abdominal or mediastinal from January 2008 June 2017 were included a prospectively maintained database and retrospectively reviewed. The sensitivity, specificity, accuracy detection neoplastic diseases calculated. Candidate...
We herein report the case of a 74-year-old man who underwent surgery 9 years after his initial visit and was pathologically diagnosed with signet-ring cell carcinoma (SRCC) derived from main-duct-type intraductal papillary mucinous neoplasm (MD-IPMN). At first imaging examination, only small pancreatic cyst mild dilation main duct (MPD) detected in head. Eventually, MD-IPMN mural nodules MPD (30 mm) developed body, while head remained unchanged. Total pancreatectomy performed as SRCC an...
Although both radial- and convex-arrayed endoscopic ultrasonography (EUS) scopes are widely used for observational EUS examinations, there have been few comparative studies on their power of visualization. The aim this study was to evaluate the capability these observation pancreatobiliary junction.The rate successful visualization junction retrospectively compared between a radial-arrayed echoendoscope, from prospectively maintained database. Study periods were defined as January 2010...
With the advent of deep submicron age, circuit performance is strongly impacted by process variations and influence on delay to power-supply voltage increases more due CMOS feature size shrinkage. Power grid optimization which considers timing error risk caused IR drop becomes very important for stable hi-speed operation system-on-chip. Conventionally, a lot power algorithms have been proposed, most them use as their object functions. However, an indirect metric we suspect that it vague real...
Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory characterized by the infiltration of IgG4-positive plasma cells and fibrosis in organs throughout body. IgG4-RD involvement gastrointestinal (GI) tract (IgG4-related GI disease; IgG4-GID) rare, concept remains unclear. Generally, IgG4-GID has been reported with morphological changes, including ulcers, strictures, submucosal tumors. Here, we report case persistent diarrhea abdominal pain which typical endoscopic findings...