A5040617174- Nutritional Studies and Diet
- Multiple Myeloma Research and Treatments
- Digestive system and related health
- Neuropeptides and Animal Physiology
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Emergency and Acute Care Studies
- Diet and metabolism studies
- Cancer Treatment and Pharmacology
- Apelin-related biomedical research
- Sepsis Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cardiac Arrest and Resuscitation
- Receptor Mechanisms and Signaling
- Nutrition and Health in Aging
- Long-Term Effects of COVID-19
- Radiopharmaceutical Chemistry and Applications
- Cardiac Imaging and Diagnostics
- Hypothalamic control of reproductive hormones
- Galectins and Cancer Biology
- Chemical Synthesis and Analysis
- Eosinophilic Esophagitis
- T-cell and B-cell Immunology
- Pneumocystis jirovecii pneumonia detection and treatment
Association pour l'Utilisation du Rein Artificiel dans la région Lyonnaise
2023-2024
Université Sorbonne Paris Nord
2020-2023
Inserm
2020-2023
Hôpital Avicenne
2020-2023
University Hospital Ulm
2014-2023
Université Paris Cité
2020-2023
Assistance Publique – Hôpitaux de Paris
2021-2023
Sorbonne Paris Cité
2020-2023
Equipe de Recherche en Epidémiologie Nutritionnelle
2021-2022
Centre de Recherche Épidémiologie et Statistique
2021
Clinical features of COVID-19 have been mostly described in hospitalized patients with and without ICU admission. Yet, up to 80% are managed an outpatient setting. This population is poorly documented. In France, health authorities recommend management presenting mild-to-moderate symptoms. The aim this study was describe their clinical characteristics. took place emergency medical dispatching center located the Greater Paris region. Patients included survey met confirmed infection criteria...
The quantity and activation state of adipose tissue macrophages (ATMs) impact the development obesity-induced metabolic diseases. Appetite-controlling hormones play key roles in obesity; however, our understanding their effects on ATMs is limited. Here, we have shown that human mouse express NPFFR2, a receptor for appetite-reducing neuropeptide FF (NPFF), NPFFR2 expression upregulated by IL-4, an M2-polarizing cytokine. Plasma levels NPFF decreased obese patients high-fat diet-fed mice...
Through the development of a new class unnatural ornithine derivatives as bioisosteres arginine, we have designed an orally active peptidomimetic antagonist neuropeptide FF receptors (NPFFR). Systemic low-dose administration this compound to rats blocked opioid-induced hyperalgesia, without any apparent side-effects. Interestingly, also observed that potentiated analgesia. This derivative provides novel therapeutic approach for both improving analgesia and reducing hyperalgesia induced by...
Zusammenfassung Ziel: Für die endovaskuläre Brachytherapie stehen unterschiedliche Radionuklide zur Verfügung. Ein interessantes Konzept ist Nutzung eines flüssigen Betastrahlers in einem Ballonkatheter. Re-188 kann aus Generatorsystem gewonnen werden und steht somit täglich Es sollten dosimetrische Daten erhoben werden. Methode: wurde radiale Abnahme der Dosis von bei typischen Dilatationskatheter (Durchmesser 3 mm, Länge 20 mm) berechnet mit TLD-Messungen verglichen. Ergebnisse: Bei einer...
Sepsis causes a high rate of mortality and long-term morbidity, associated with an imbalance innate immunity against infections inflammation. Obesity diabetes increase the risk for disease severity. Monocyte dysfunction plays major role justify further investigations.To investigate distribution inflammatory phenotypes in circulating monocyte subsets patients manifesting sepsis including septic shock without obesity diabetes.A total 235 blood samples were tested from critically ill adult...
(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, mono-saccharides polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS). Our aim was to study FODMAP consumption controls IBS participants a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort completed Rome IV IBS-SSS questionnaire cross sectional study. Among them, 27,949 eligible had previously three 24-h recalls...
A highly-sensitive sandwich enzyme-linked immunosorbent \(ELISA) procedure was developed for detecting human fetuin \(HFA), a speci c biomarker plethora of various infection and in ammation associated diseases.In this one-step antibody \(Ab) immobilization, the capture anti-HFA Ab formed stable complex with 3-aminopropyltriethoxysilane \(APTES), via ionic hydrophobic interactions.The adsorbed on microtiter plate \(MTP) as an ELISA platform HFA, exhibited linearity from 4.9 pg mL -1 to 20 ng...
Abstract Introduction In cardiac arrest (CA), time is directly predictive of patient prognosis. The increase in mortality resulting from delayed cardiopulmonary resuscitation has been quantified minute by minute. Times reported such a situation could reflect bias referred to as “digit preference”. This phenomenon leads privilege certain numerical values (like 2, 5, or 10) over others 13). We investigated this times during management national register. Methods analyzed data the French...
A number of results emphasize autoimmune characteristics in psychiatric diseases, including Affective (AF) and Schizophrenic (SZ) Spectrum Disorders. In this study, serum/plasma samples n=34 AF (ICD-10 F30-F33) n=47 SZ F20-F25) patients, as well n=10 healthy controls (HDs), were tested for autoantibodies directed against cytokines different Type I, II III interferons using Luminex® technology. Significant amounts found. Specifically, IFN- λ (AF n=4, n=4), ω n=2, n=3), TNF-α n=1) selectively...
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: The therapeutic landscape in multiple myeloma (MM) has changed dramatically recent years. Pharmacological innovation resulted increased complexity of treatment choice. Discrepancies within Europe are observed regarding reimbursement availability MM drugs. Real practice differs from clinical trial designs needs to be investigated against official guidelines. Aims: Identify patterns EU5 countries based on real-world...
Abstract COVID-19, the pandemic infection caused by SARS-CoV-2, may take highly variable clinical courses, ranging from symptom-free and pauci-symptomatic to fatal disease. The goal of current study was assess association COVID-19 courses controlled patients’ adaptive immune responses without progression severe disease with Human Leukocyte Antigen (HLA) genetics, presence or absence near-loss-of-function delta 32 deletion mutant C-C chemokine receptor type 5 (CCR5) AB0 blood group antigens....