A5047212534- Heavy Metal Exposure and Toxicity
- Arsenic contamination and mitigation
- Nanoparticle-Based Drug Delivery
- Drug-Induced Hepatotoxicity and Protection
- Trace Elements in Health
- 3D Printing in Biomedical Research
- SARS-CoV-2 and COVID-19 Research
- Graphene and Nanomaterials Applications
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
- Cancer Cells and Metastasis
- Medicinal Plant Extracts Effects
- Poisoning and overdose treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Nanoparticles: synthesis and applications
- Ferroptosis and cancer prognosis
- Chemotherapy-induced organ toxicity mitigation
- Medicinal Plants and Neuroprotection
- Immune cells in cancer
- Phytochemistry and Biological Activities
- Neurogenesis and neuroplasticity mechanisms
- Nanoplatforms for cancer theranostics
- Alkaloids: synthesis and pharmacology
- RNA Interference and Gene Delivery
Tehran University of Medical Sciences
2014-2023
University of Massachusetts Dartmouth
2021-2023
University of Basel
2020
Kettering University
2020
Tarbiat Modares University
2012-2013
There are increasing concerns regarding the toxic effects of chlorpyrifos (CPF) on human health. Curcumin (CUR) is a yellow pigment isolated from turmeric ground rhizome Curcuma longa Linn., which has been identified as an antioxidant agent. This study was designed to examine protective effect CUR and vitamin E (Vit E) CPF-induced lung toxicity. Rats were divided into seven groups: control, CPF (13.5 mg/kg, orally), + (100 300 respectively, α-tocopherol E, 150 intraperitoneally),...
Sepsis is a debilitating systemic disease and described as severe irregular inflammatory reaction syndrome (SIRS) against infection. We employed CLP (Cecal Ligation Puncture) model in rats to investigate anti-inflammatory antioxidant effects of phloretin, natural agent, its protective effect on liver tissue damage caused by sepsis.Male Wistar albino were randomly divided into three groups: sham group, induced sepsis group phloretin treated group. was method. 50 mmol/kg Phloretin administered...
The aim of this study was to investigate the possible protective effect ellagic acid (EA) against gentamicin (GEN)-induced nephrotoxicity using biochemical, molecular and histopathological approaches.Rats (n = 24) were divided into four groups: control, GEN (100 mg/kg, i.p.), EA (10 p.o.) plus EA. regimes administered for 10 successive days. 24 h after last treatment, kidney blood samples collected.Ellagic treatment significantly reduced plasma creatinine urea levels, which initially...
Despite many advances in cancer treatment, still remains a major global health problem owing to its high rate of recurrence, the tendency metastasize, and development drug resistance. In addition animal models, researchers can employ vitro tumor models mimic vivo microenvironment with purpose discovering new therapeutic approaches. order engineer realistic that recapitulate not only progression but also angiogenesis metastasis, complex interacting factors must be taken into account....
Context: The application of bleomycin is limited due to its side effects including lung toxicity. Silymarin a flavonoid complex isolated from milk thistle [Silybum marianum L. (Asteraceae)] which has been identified as an antioxidant and anti-inflammatory compound.
Disease type affects the natural targeting capacity of protein corona coated antiparticles.
Background: Among various theories for the origin of cancer, "stemness phenotype model" suggests a dynamic feature tumor cells in which non-cancer stem (non-CSCs) can inter-convert to CSCs. Differentiation with histone-deacetylase inhibitor, vorinostat (SAHA), induce differentiate as well enforces non-CSCs reprogram To avoid this undesirable effect, one block Wnt-βcatenin pathway. Thus, dual delivery system SAHA and blocker will be beneficial induction differentiation Protein corona (PC)...
It is estimated that around 140 million people are drinking highly contaminated water with arsenic (As) as a natural earth's crust component. On the other hand, prevalence of neurodegenerative disorders, especially Alzheimer's disease, constantly increasing. The aim present study was to investigate correlation between oral trioxide exposure and its impact on tau protein phosphorylation at Ser262. Fifty-four male mice were randomly divided into three groups freely accessed food 1 10 ppm for 3...
A campaign was conducted to assess the PM1 concentration and elemental composition on platforms adjacent outdoor areas of an underground subway station (Imam Khomeini) a surface (Sadeghiye) in Tehran from June 2014 November 2014. The respective mean concentrations Imam Khomeini were 42.04 30.92 µg/m3 for Sadeghiye 31.42 26.02 µg/m3. Statistical analyses demonstrated that stations influenced by ambient air these (p < 0.05). found be highly enriched with Fe metro systems, which more frequently...
Abstract Benzo[α]pyrene (BaP) can have significant role in the development of breast cancer via aryl hydrocarbon receptor (AhR) activation. AhR activation has been studied several functions such as survival, migration and invasion cells. In cancer, integrins contribute to migration/invasion process are regulated by nuclear factor activated T cells (NFAT) transforming growth (TGF) beta pathways. The aim present study was examine effect BaP, an activator cyclosporine A (CsA), inhibitor NFAT on...