A5059090693- Diabetes and associated disorders
- Growth Hormone and Insulin-like Growth Factors
- Childhood Cancer Survivors' Quality of Life
- Thyroid Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Genetic Syndromes and Imprinting
- Adrenal Hormones and Disorders
- Pituitary Gland Disorders and Treatments
- Pancreatic function and diabetes
- Diabetes Management and Research
- Digestive system and related health
- Metabolism, Diabetes, and Cancer
- Ovarian function and disorders
- Electrolyte and hormonal disorders
- Bone health and treatments
- Bone Metabolism and Diseases
- Prenatal Screening and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Diabetes Treatment and Management
- Neuroblastoma Research and Treatments
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Parasitic Infections and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Pediatric health and respiratory diseases
Jagiellonian University
2015-2024
Uniwersytecki Szpital Dziecięcy
2006-2024
Child, Adolescent and Family Mental Health
2022
Interruption of spinal cord (SC) continuity leads to functional loss below the lesion level. The purpose this study was evaluate safety and efficacy bone marrow nucleated cell (BMNC) multiple mesenchymal stem (MSC) transplantations in injury (SCI). A patient with total SC interruption at Th2-3 level underwent experimental therapy BMNC MSC followed intensive neurorehabilitation treatment. At admission, 6 h after SCI, scored ASIA A, had a Th1 sensation level, paraplegia sphincter palsy,...
The aim of the study was to evaluate clinical phenotypes glucokinase-maturity-onset diabetes young (GCK-MODY) pediatric patients from Southwest Poland and search for phenotype-genotype correlations.We conducted a retrospective analysis data on 37 CGK-MODY consisting 21 girls 16 boys ages 1.9-20.1 (mean 12.5±5.2) years, treated in our centre time period between 2002 2013.GCK-MODY carriers were found frequency 3% among 1043 mellitus (DM) constituted second most numerous group DM patients,...
<b>Aims:</b> To investigate the relationship between bone-derived osteocalcin (OC), osteoprotegerin (OPG), Receptor Activator of Nuclear Factor NF-ĸB ligand (RANKL), and fat tissue-derived leptin adiponectin with a clinical outcome type 1 diabetes mellitus (T1DM) in children adolescents. <b>Methods:</b> 78 patients (43 girls 35 boys), aged 11.5±4.3 years T1DM 11 age- BMI-matched controls were included into study. Patients divided 3 groups according to HbA1c level, I – below 7% [53 mmol/mol],...
Recombinant human growth hormone (rhGH) treatment is an established management in patients with Prader–Willi syndrome (PWS), promotion and improvement body composition possibly the metabolic state. We compared anthropometric characteristics, insulin-like factor 1 (IGF1) levels, parameters bone age/chronological age index (BA/CA) 147 children PWS, divided according to of rhGH start into four groups, corresponding nutritional phases PWS. analysed time points: baseline, rhGH1 (1.21 ± 0.81...
Numerous clinical and experimental studies suggest that growth factors may contribute to the development of diabetic microvascular complications. The aim study was test hypothesis in adolescents with type-1 diabetes mellitus microalbuminuria (MA) there are specific disorders serum insulin-like factor-1 (IGF-1) concentrations its binding proteins, IGFBP-1 IGFBP-3, could be importance pathogenesis complications.25 MA, 24 without complications, 17 controls were examined. There no differences...
To present the outcomes of ultrasound (US) follow-ups in children with autoimmune thyroid disease who did not have a nodule on admission but developed papillary carcinoma (PTC) and to characterize parenchymal changes gland prior development PTC.A retrospective US scan review 327 patients diagnosed AIT was performed. Forty (40/327, 12.2%) presented nodular variant normoechogenic background. Eleven (11/327, 3.4%, 11/40, 27.5%) presenting this were PTC (nine females-mean age 15.3 years; two...
Introduction Autoimmune disorders, IgA deficiency, and allergies seem to be common among individuals with 18q deletion syndrome [OMIM 601808]. We aimed determine the prevalence, mechanism, genetic background of autoimmunity, immune allergy in a cohort patients deletions. Material Methods Medical registries social media were used recruit patients. Microarray oligonucleotide comparative genomic hybridization (aCGH) (Agilent, Santa Clara, CA, USA) was performed all identify size location...
Background: Some studies suggest that IL-6 is connected with glucose metabolism and insulin action, so like IGF-IGFBPs system it could play the role in diabetes etiopathogenesis.
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Wędrychowicz A, Hull B, Tyrawa K, Kalicka-Kasperczyk Zieliński G, Starzyk J. Cushing disease in children and adolescents – assessment of the clinical course, diagnostic process, effects treatment experience from a single paediatric centre. Pediatric Endocrinology Diabetes Metabolism. 2019;25(3):127-143. doi:10.5114/pedm.2019.87179. APA Wędrychowicz, A., Hull, B., Tyrawa, K., Kalicka-Kasperczyk, Zieliński, G., &...
Total parenteral nutrition (TPN) is still of great importance for haematopoietic stem cell transplantation (HSCT) patients because one the major adverse effects high-dose therapy followed by HSCT an inadequate oral intake. The aim study was analysis TPN young in period. Twenty-two 1·8–20·8 year-old, median 5·4, treated with and autologous malignancy were included into study. Grafts contained 1·35–7·9 × 10 6 , 3·75 CD34 + cells/kg. Engraftment occurred as follows: granulocytes >0·5 9 /l on...
Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in childhood. Because acute glycaemic com-plications account for concerns management T1DM children, special attention during challenging time global COVID-19 pandemic required to prevent deteriorations resulting hospitalization.is assess how influenced incidence and causes hospitalizations emergency room visits adolescents with established type mellitus, characterize admitted population.The study was conducted as a...
Survivors of pediatric hematopoietic stem cell transplantation (HSCT) are known to be at risk developing endocrine abnormalities, but occurrence diabetes mellitus (DM) is a relatively recent observation. We present 17.5-year-old girl with DM after high-dose radio- and chemotherapy followed by allogeneic HSCT for the treatment acute lymphoblastic leukemia, diagnosed when she was 10 years old. In posttransplantation period, multiple chronic complications occurred. Among them, we observed graft...
The aim of our study was to determine the relationship between neuropeptide B (NPB), W (NPW), nutritional and antioxidant status selected fat- bone-derived factors in type 1 diabetes mellitus (T1DM) treated using pens (T1DM pen group) or insulin pumps pump order investigate potential role NPB NPW clinical outcomes T1DM.
Background: Cyclic Cushing's disease (CD) has been described in about 15% of adult patients with CD. In the pediatric population, diagnosis CD is rare and cyclic presentations are not adequately understood or described. Moreover, prepubertal usually do present typical signs symptoms CD, which can obscure delay diagnosis. this paper, we report a case age girls whose etiology was pituitary corticotropinoma. Case presentation: A Caucasian 7.8 year old girl admitted to endocrinology for...
Patients with heterozygous inactivating mutations in the gene encoding glucokinase, which causes type 2 maturity-onset diabetes of young (MODY2), have mild fasting hyperglycemia that usually remains considerably stable during life and requires only diabetic diet as treatment. Atypical course disease is uncommon. An 11-year-old, prepubertal, Caucasian overweight boy (BMI 22.5 kg/m2) gynecomastia/steatomastia was diagnosed on basis an oral glucose tolerance test without any typical symptoms...
The aim of our study was to analyze the incidence and clinical characteristic celiac disease (CD) in pediatric population with type 1 diabetes mellitus (T1DM).The data 880 patients T1DM, 429 girls, mean age 12.14 ±4.0 years retrospectively retrieved from medical records. Patients T1DM CD were selected a detailed analysis prevalence its at time diagnosis performed. compared previous center published decade ago.CD suspected 85/880 (9.65%) on base results serological tests, but finally...
Oncologic treatment can affect the adrenal glands, which in stressful situations may lead to life threatening crisis. The aim of study was assess function pediatric acute lymphoblastic leukemia (ALL) survivors and identify best markers for this assessment.Forty-three ALL survivors, mean age 8.5±3.6 years 45 sex-matched healthy controls were recruited study. patients assessed once within five following oncological completion. Fasting blood samples collected from all participants measure:...