A5021503178- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Celiac Disease Research and Management
- Prenatal Screening and Diagnostics
- Neurological and metabolic disorders
- Retinopathy of Prematurity Studies
- Digestive system and related health
- Diet, Metabolism, and Disease
- Infant Nutrition and Health
- Helicobacter pylori-related gastroenterology studies
- Growth Hormone and Insulin-like Growth Factors
- Blood Pressure and Hypertension Studies
- Renal Transplantation Outcomes and Treatments
- Pressure Ulcer Prevention and Management
- Diet and metabolism studies
- Neurogenetic and Muscular Disorders Research
- Emotional Intelligence and Performance
- Skin Diseases and Diabetes
- Metabolism and Genetic Disorders
Children's Memorial Health Institute
2015-2024
Instytut Matki i Dziecka
2007-2015
Purpose To assess the optical coherence tomography angiography (OCTA) retinal vessel density and foveal avascular zone (FAZ) in children with type 1 diabetes (T1D) compare potential pathologic early changes this population to healthy age-matched controls. Methods This study included 130 pubescent children: 94 T1D (188 eyes) 36 of their control group (60 eyes). OCTA was performed using AngioVue (Avanti, Optivue). FAZ area (mm2) superficial plexus, whole capillary (wsVD), fovea (fsVD),...
Introduction The gut microbiota may be relevant in the development of type 1 diabetes (T1D). We examined effects Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 on beta-cell function children with newly diagnosed T1D. Research design methods Children aged 8–17 years (within 60 days) T1D were enrolled a double-blind, randomised controlled trial which they received L. B. at dose 10 9 colony-forming units or placebo, orally, once daily, for 6 months. follow-up was 12 primary outcome...
Abstract Background The incidence of childhood type 1 diabetes (T1D) varies greatly between populations, and the estimates and/or predictions rates would aid in adequate planning health care resources. study's aim was to assess T1D paediatric population eastern central Poland. Methods In this cohort study covering period from January 2010 December 2014, data were collected for children adolescents below 18 years age with newly diagnosed living A total 2174 included analysis. Central...
To assess the retinal and choroidal thickness ganglion cell complex (GCC) in pubescent children with type 1 diabetes (T1D) without diabetic retinopathy (DR), using spectral domain optical coherence tomography (SD-OCT).Sixty-four right eyes of 64 subjects T1D 45 age-matched healthy volunteers (control group) were enrolled this study. The mean age controls was 15.3 (±SD = 2.2) 14.6 1.5), respectively. SD-OCT performed RTVue XR Avanti. Ganglion (GCC), GCC focal loss volume (FLV), global (GLV),...
Recombinant human growth hormone (rhGH) treatment is an established management in patients with Prader–Willi syndrome (PWS), promotion and improvement body composition possibly the metabolic state. We compared anthropometric characteristics, insulin-like factor 1 (IGF1) levels, parameters bone age/chronological age index (BA/CA) 147 children PWS, divided according to of rhGH start into four groups, corresponding nutritional phases PWS. analysed time points: baseline, rhGH1 (1.21 ± 0.81...
There are several observations that the onset of coronavirus 19 (COVID-19) pandemic was associated with an increase in incidence diabetic ketoacidosis (DKA). However, due to heterogeneity study designs and country-specific healthcare policies, more national-level evidence is needed provide generalizable conclusions.To compare rate DKA Polish children diagnosed type 1 diabetes (T1D) between first year COVID-19 (15 March 2020 15 2021) preceding 2019 2020).Reference centers 13 regions (covering...
Aim. To evaluate the influence of metabolic parameters and treatment method in children with type 1 diabetes (T1D) on optical coherence tomography angiography (OCTA) results as early markers diabetic retinopathy (DR). Material Methods. This prospective study enrolled 175 consecutive T1D. OCTA was performed using AngioVue (Avanti, Optovue). Whole superficial capillary vessel density (wsVD), fovea (fsVD), parafovea (psVD), whole deep (wdVD), (fdVD), (pdVD), foveal thickness (FT), parafoveal...
Despite its characteristic symptoms, type 1 diabetes (T1D) is still diagnosed late causing the development of diabetic ketoacidosis (DKA). The aim this study was to estimate incidence DKA and factors associated with acidosis at T1D recognition in Polish children aged 0-17.The population consisted 2100 newly years 2010-2014 7 hospitals eastern central Poland. living these areas accounts for 35% population. defined as a capillary pH < 7.3, blood glucose > 11 mmol/L. analyzed data included age,...
Overweight children are growing problem as in the pediatric, well diabetic population. The aim of study was to research percentage overweight and obesity a group adolescents with type 1 diabetes, analyzethe lipid parameters, risk factors these abnormalities.The consist 60 (including 32 girls, 53.3%), aged above 12 years (mean age for girls 14.6+/-0,3years, boys 15.6+/-0.4 years) diabetes duration (girls 5.7+-0.6 years, 4.4+/-0.8 years). Statistical analysis performed using Statistica v 9.0...
Puberty in children with Prader-Willi syndrome (PWS) is usually delayed and/or incomplete but some patients premature/early adrenarche observed. We assessed the premature (PA) PWS during recombinant human growth hormone (rhGH) therapy and influence of PA on course central puberty (CP), rhGH efficacy safety, patients’ metabolic state. Forty-nine were treated rhGH, 11 presented (group 1) 14 had normal 2). was observed 22.5% rhGH. The mean time between start adrenarche, dose, velocity...
Abstract Aim The seasonal variation of incidence type 1 diabetes (T1D) theory supports the hypothesis that environmental factors play a role in onset disease. aim this study is to assess seasonality month diagnosis children with T1D Poland. Material and methods group consisted 2174 from eastern central Poland diagnosed between 2010 2014. Analysis was performed different age groups, based on place residence (rural/urban area) depending sex. Results We noted significant peak January minimum...
Neurological complications of diabetic ketoacidosis are considered to be a serious clinical problem. The most common complication is cerebral edema. However, these neurological also include less entities such as ischemic or hemorrhagic stroke, venous and sinus thrombosis peripheral neuropathy. We present case 9-year old girl admitted our intensive care unit with new onset type 1 diabetes, ketoacidosis, edema, multifocal vasogenic brain lesions bilateral lower limb paresis. patient developed...
Patients with type 1 diabetes (T1D) are at higher risk of celiac disease (CD). Recently, intestinal fatty acid binding protein (I-FABP) has been shown to be a serological biomarker impaired barrier in CD. Thus, the aim this study was verify whether I-FABP could an early marker CD pediatric T1D patients. measured sera patients (n = 156), active 38), (T1D-CD, n= 51), and age-matched healthy children 55). Additionally, determined negative serology least one year before diagnosis (T1D-CD-1, n...
Biochemical abnormalities in the course of type 1 diabetes (T1D) may cause production/activation various proteins and peptides influencing treatment causing a risk complications. The aim this study was to assess concentrations selected serum substances involved pathogenesis T1D correlate their with duration T1D. included patients (n = 156) at age 3-17, who were divided according disease into those newly diagnosed 30), after 3-5 77), 6-7 25), over 7 24) years from onset T1D, age-matched...
Sleep-related breathing disorders (SRBDs) can be present in children with simple obesity and Prader–Willi syndrome (PWS) influence an individual diagnostic treatment approach. We compared frequency severity of SRBDs PWS, both without on recombinant human growth hormone (rhGH) treatment, correlation insulin resistance tests. A screening polysomnography-polygraphy (PSG), the oral glucose tolerance test (OGTT) homeostasis model assessment (HOMA-IR) were analysed three groups patients—with...
Sleep-related breathing disorders (SRBD) are commonly present in patients with Prader-Willi syndrome (PWS). Recombinant human growth hormone (rhGH) treatment is reported to improve function PWS, but the findings not explicit.Screening polysomnography- polygraphy (PSG), assessing nasal respiratory flow, effort, and blood oxygen saturation, was used. Group 1 - before rhGH therapy (n = 11, mean age 3.0 years); PSG repeated after start of a time 0.9 years six (Group 1a). 2 on treatment, for four...
Objective To assess the influence of thyroid hormones status and coexistence autoimmune thyroiditis on optical coherence tomography (OCT) angiography (OCTA) results in children with Type 1 diabetes (T1D). Research Design Methods In prospective, observational study (n = 175) we analyzed impact OCT differences between matched groups T1D 84; age 13.14 ± 3.6; duration 5.99 3.3 years) (AT) 20; 13.94 6.7 4 years). We following parameters: fovea avascular zone (FAZ), foveal thickness (FT),...
Genotype–phenotype correlation in patients with Prader–Willi syndrome (PWS) has still not been fully described. We retrospectively analysed data of 147 and compared groups according to genetic diagnosis: paternal deletion chromosome 15q11-q13 (DEL 15, n = 81), maternal uniparental disomy (UPD 10), excluded DEL 15 or imprinting centre defect, UPD/ID, 30). Group had an earlier diagnosis recombinant human growth hormone (rhGH) start (p 0.00), a higher insulin-like factor 1 (IGF1) level group...
To assess choroidal thickness (CT) in children with type 1diabetes (T1D) regarding their pubertal status and seek for factors influencing this parameter, using optical coherence tomography.333 eyes out of 167 T1D without symptoms diabetic retinopathy (mean age 12.81 ± 3.63 years, diabetes duration 4.59 3.71 years) were enrolled. CT all quadrants was evaluated. The studied population divided into three groups: prepubertal, postpubertal. multivariate regression model carried metabolic...