A5025783551- Dementia and Cognitive Impairment Research
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Neurological Disease Mechanisms and Treatments
- Migration, Health and Trauma
- Down syndrome and intellectual disability research
- Obstructive Sleep Apnea Research
- Nerve injury and regeneration
- Neurological Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease Mechanisms and Treatments
- Biosimilars and Bioanalytical Methods
- Cardiovascular and Diving-Related Complications
- Migration and Labor Dynamics
- Racial and Ethnic Identity Research
New York Hospital Queens
2023-2024
Institute on Aging
2024
Columbia University
2022-2024
NewYork–Presbyterian Hospital
2023-2024
Texas Health Dallas
2023
Columbia University Irving Medical Center
2023
University of Pennsylvania
2018-2022
Secondary prevention clinical trials for Alzheimer's disease (AD) target amyloid accumulation in asymptomatic, amyloid-positive individuals, but it is unclear to what extent other pathophysiological processes, such as small vessel cerebrovascular disease, account participant performance on the primary cognitive outcomes those trials. White matter hyperintensities are areas of increased signal T2-weighted magnetic resonance imaging (MRI) that reflect disease. They associated with functioning...
Abstract Background and Objectives Hypertensive disorders of pregnancy (HDP) are associated with a long‐term risk maternal cognitive decline. Limited data exist regarding brain structure in midlife after HDP. We examined the association between prior HDP neuroimaging markers microvascular injury, detected on high‐resolution MRI. Methods conducted pilot study embedded within nuMoM2b Heart Health Study, multicenter prospective cohort nulliparous US individuals recruited 2010 2013 first...
Abstract In the intermediate stages of amyotrophic lateral sclerosis (ALS), surviving motor neurons (MNs) that show intrinsic resistance to TDP-43 proteinopathy can partially compensate for loss their more disease-susceptible counterparts. Elucidating mechanisms this compensation may reveal approaches attenuating impairment in ALS patients. rNLS8 mouse model ALS-like pathology driven by doxycycline-regulated neuronal expression human lacking a nuclear localization signal (hTDP-43ΔNLS), slow...
Abstract We determined the extent to which obstructive sleep apnea (OSA) is associated with increased cerebrovascular disease and amyloid burden, relation of two processes across clinical Alzheimer’s (AD) diagnostic groups in adults Down syndrome (DS). Adults DS from Biomarkers Disease Syndrome (ADDS) study were included given available research MRI (n = 116; 50 ± 8 years; 42% women) PET scans 71; 7 39% at time analysis. Participants characterized as cognitively stable (CS; 64%), mild...
High-grade carotid artery stenosis may alter hemodynamics in the ipsilateral hemisphere, but consequences of this effect are poorly understood. Cortical thinning is associated with cognitive impairment dementia, head trauma, demyelination, and stroke. We hypothesized that hemodynamic impairment, as represented by a relative time-to-peak (TTP) delay on MRI hemisphere to stenosis, would be cortical hemisphere.We used baseline data from NINDS-funded Carotid Revascularization Medical Management...
Abstract Background The characterization of Alzheimer’s disease (AD) and AD related dementias (ADRD) pathophysiology has been revolutionized by the development highly sensitive blood‐based biomarkers. Although biomarkers allow for greater access, cost effectiveness, scalability, there are limitations their implementation in resource‐constrained low‐ middle‐income countries (LMICs) rural settings, where access to equipment, freezers, assays is often limited. Dried blood spot (DBS) collection...
Objective: Previous research established that white matter hyperintensities (WMH), a biomarker of small vessel cerebrovascular disease, are strong predictors cognitive function in older adults and associated with clinical presentation Alzheimer’s disease (AD), particularly when distributed posterior brain regions. Secondary prevention trials, such as the Anti-Amyloid Treatment Asymptomatic (A4) study, target amyloid accumulation asymptomatic positive individuals, but it is unclear extent to...
Objective: Neuropsychiatric symptoms concerning mood are common in Alzheimer's disease (AD), but it is unclear if they etiologically related to AD pathophysiology or due factors considered be non-pathogenic, such as small vessel cerebrovascular disease. New generation clinical trials for often enroll participants with evidence of pathophysiology, indexed by amyloid PET scanning, who cognitively asymptomatic. We used screening data from the Anti-Amyloid Treatment Asymptomatic (A4) study...
Objective: Alzheimer’s disease (AD) pathophysiology, including β-amyloid (Aβ), can be appreciated with molecular PET imaging. Among older adults, the distribution of Aβ standard uptake value ratios (SUVR) is typically bimodal and a diagnostic cut applied to define those who are amyloid ‘positive’ ‘negative’. However, it unclear whether dynamic range SUVRs in positive negative individuals meaningful associated cognition. Previous work by Insel colleagues (2020) used screening data from...
Abstract Background Health and Aging in Africa Longitudinal Study of an INDEPTH community South (HAALSI) is a sister study to the US‐based Retirement Study. The purpose HAALSI characterize social, economic, biological, physical, mental health factors population‐representative cohort older adults rural Agincourt, Africa. Beginning 2020, as part Alzheimer’s disease related disorders (ADRD) substudy, we conducted neuropsychological evaluations structural magnetic resonance imaging (MRI) subset...