A5101770256- Inhalation and Respiratory Drug Delivery
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Gastroesophageal reflux and treatments
- Electrospun Nanofibers in Biomedical Applications
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Drug Solubulity and Delivery Systems
- Pneumocystis jirovecii pneumonia detection and treatment
- High Altitude and Hypoxia
- Polyomavirus and related diseases
- Microencapsulation and Drying Processes
- Molecular Sensors and Ion Detection
- Granular flow and fluidized beds
- Advanced biosensing and bioanalysis techniques
- Pharmaceutical studies and practices
- Travel-related health issues
- Phagocytosis and Immune Regulation
- Drug Transport and Resistance Mechanisms
- Immune cells in cancer
Xuzhou Medical College
2015-2023
China Pharmaceutical University
2012-2015
This study aims to develop oseltamivir phosphate (OP) liposomes as inhalation powders by spray-drying based on the single factor investigation, which was mainly composed of lactose, l-leucine and mannitol. It found that ratio OP (1:10), inlet temperature (110 °C) airflow rate (2.3 mL/min) showed optimized physical properties liposomes. Deposition evaluated after aerosolization at 600 L/h via Aerolizer® into a twin-stage impinger. The concentrations carboxylate (OSCA) in rats plasma using...
Background: The clearance of nanomaterials (NMs) from the liver is essential for clinical safety, and their hepatic primarily determined by co-disposition process various types cells. Studies this subsequent routes are urgently needed organic NMs, which used as drug carriers more commonly than inorganic ones. Materials methods: In study, chitosan-based nanoparticles (CsNps) macrophages hepatocytes at both cellular animal levels well biological elimination were investigated. RAW264.7 Hepa1-6...
The performance of dry powder aerosol delivery systems depends not only on the formulation but also inhalers (DPIs). Effects turbulence, grid, mouthpiece, inlet size, air flow, and capsule DPIs have been investigated previously. Considering dispersion in is a time-dependent process, residence time supposed to great impact efficiency. This study sought investigate effect commercial DPI Aerolizer(®).A standard Aerolizer(®) (SD) five modified devices (MD1, MD2, MD3, MD4, MD5) were employed for...
Little has been investigated about the intracellular fate of organic nanoparticles (NPs), which is important for safety and drug delivery efficiency NPs. In this work, disassociation hydrolysis albumin NPs were detected based on FRET.