A5046030770- Escherichia coli research studies
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- Cell death mechanisms and regulation
- Bacterial Genetics and Biotechnology
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Genomic variations and chromosomal abnormalities
- Genetics, Aging, and Longevity in Model Organisms
- Salmonella and Campylobacter epidemiology
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Antibiotic Resistance in Bacteria
- Cerebrovascular and genetic disorders
Boston Micromachines (United States)
2024
UK Research and Innovation
2018
Imperial College London
2010-2016
The genus Salmonella contains two species, S. bongori and enterica. Compared to the well-studied enterica there is a marked lack of information regarding genetic makeup diversity bongori. has been found predominantly associated with cold-blooded animals, but it can infect humans. To define phylogeny this compare enterica, we have sequenced 28 isolates representing most known This cross-species analysis allowed us confidently differentiate ancestral functions from those acquired following...
The human pathogens enteropathogenic (EPEC) and enterohemorrhagic Escherichia coli the related mouse pathogen Citrobacter rodentium subvert a variety of host cell signaling pathways via their plethora type III secreted effectors, including triggering an early apoptotic response. EPEC-infected cells do not develop late symptoms, however. In this study we demonstrate that NleH family homologs Shigella effector kinase OspG, blocks apoptosis. During EPEC infection, effectors inhibit elevation...
Enteropathogenic Escherichia coli (EPEC) strains are diarrhoeal pathogens that use a type III secretion system to translocate effector proteins into host cells in order colonize and multiply the human gut. Map, EspI NleH1 conserved EPEC effectors possess C-terminal class I PSD-95/Disc Large/ZO-1 (PDZ)-binding motif. Using PDZ array screen we identified Na(+)/H(+) exchanger regulatory factor 2 (NHERF2), scaffold protein involved tethering recycling ion channels polarized epithelia contains...
Clostridium difficile is a leading cause of nosocomial infections, causing spectrum diseases ranging from diarrhoea to pseudomembranous colitis triggered by range virulence factors including C. toxins A (TcdA) and B (TcdB). TcdA TcdB are monoglucosyltransferases that irreversibly glycosylate small Rho GTPases, inhibiting their ability interact with effectors, guanine nucleotide exchange factors, membrane partners, disruption downstream signalling pathways cell death. In addition, targets the...
Cancer treatments have traditionally entailed system wide toxicity with debilitating side effects for the patient. The demand targeted therapies is clearly exhibited in pipeline of large pharmaceuticals where need to identify delivery vehicles that offer prospects more targeted, efficacious fewer paramount. Historically a number technologies been tried and tested including antibody drug conjugates, nanoparticles, cell surface markers targeting tumor microenvironment. Unfortunately, these...