Background: Posttraumatic stress disorder (PTSD) is associated with metabolic syndrome and various addictive behaviours. Food addiction (FA) obesity, individuals PTSD have higher rates of FA than those without. It unclear whether addictive-like eating patterns contribute to the dysfunction in PTSD.Objective: We examined relative contributions PTSD, FA, sex - as well their interactive effects systemic inflammation (CRP) components (MetS: waist circumference, glucose, triglycerides, HDL...

Abstract The relationship between the structure and a property of chemical compound is an essential concept in chemistry guiding, for example, drug design. Actually, however, we need economic considerations to fully understand fate drugs on market. We are performing here first time exploration quantitative structure-economy relationships (QSER) large dataset commercial building block library over 2.2 million chemicals. This investigation provided molecular statistics that shows average what...

Neuroendocrine tumors are a heterogeneous group of located mainly in the gastrointestinal tract or respiratory system. We aimed to determine concentrations IGF-1R, ERK2, and EGFR using ELISA method serum samples from patients with NETs control group. Results were evaluated selected demographic, clinicopathological, biochemical characteristics. The analyses performed on (80 study 62 group) showed that concentration neuroendocrine was significantly higher (p < 0.001) compared Additionally,...

Background: Potency is the broadest available biological activity data type. In turn, Ligand Efficiency (LE) a molecular descriptor that probes ratio of potency vs Heavy Atom Count (HAC), which emphasizes low HAC more than and thus has drawbacks as an estimator drug candidates. The objective was to design novel transform probe interaction in would be balanced evenly. Methods: this study, ChEMBL, PubChem, FDA approvals (fragments) were analysed. A descriptor, product pAC50 value with HAC,...

Ligand efficiency (LE) is a molecular descriptor that probes the ratio of potency vs. heavy atom count (HAC).As an estimator drug candidates, LE emphasizes low more than potency.The objective was to design novel transform where and HAC would be balanced evenly.A series descriptors SCORE were defined evaluate co-influence HAC.In particular, product ligand (PLE) designed tested using data ChEMBL, PubChem as well selected drugs drug-fragments.

Introduction: Sudden cardiac arrest is the cessation of muscle function leading to clinical death and one causes in developed countries. Disturbed functioning heart action causing sudden may result from asystole, ventricular fibrillation electromechanical dissociation. Materials methods: The purpose this work was describe a series neurological neuropsychological disorders as taking place outside hospital resuscitation lasting 20 minutes. Conclusions: Cardiac lead irreversible brain damage,...

<title>Abstract</title> The aim of the study was to identify prevalence food addiction (FA) and binge eating (BE) in a nonclinical population, explore differences between these constructs, examine psychological among individuals with any disordered pattern (FA, BE, FA+BE groups). Participants aged 18 55 completed questionnaires: Yale Food Addiction Scale (YFAS 2.0), Binge Eating (BES), PTSD Checklist for DSM-5 (PCL-5), Life Events Checklist, Adverse Childhood Experiences (ACE), Short...

Background: Posttraumatic stress disorder (PTSD) is associated with metabolic syndrome and various addictive behaviors. Food addiction (FA) obesity, individuals PTSD have higher rates of FA than those without. It unclear whether addictive-like eating patterns contribute to the dysfunction in PTSD. Objective: We examined relative contributions PTSD, FA, gender – as well their interactive effects systemic inflammation (CRP) components (MetS: waist circumference, glucose, triglycerides, HDL...

This study aimed to confirm the factorial structure of Polish Weight Self-Stigma Questionnaire (WSSQ) and test structural validity, internal consistency measurement invariance questionnaire across gender, Body Mass Index (BMI) other psychological measures. The sample was recruited from general population (N=1055), age 18–55. Participants completed WSSQ, Yale Food Addiction Scale (YFAS 2.0), Emotional Eating Restrained subscales Dutch Behavior (DEBQ), Depression, Anxiety Stress – 21 (DASS-21)...

Food addiction (FA) and posttraumatic stress disorder (PTSD) are each associated with obesity adverse psychological outcomes. The goal of this study was to generate symptom profiles based on varying levels FA PTSD symptoms. We hypothesized four profiles: PTSD+FA; PTSD; FA; healthy. In a general Polish population (N=2245), scores Checklist for DSM-5 (PCL-5), Lifetime Events (LEC), Yale Scale (YFAS) were used as indicators in the latent profile analysis. Gender Negative Urgency (SUPPS-P)...

Introduction: Neuroendocrine tumors are a diverse group of predominantly found in the gastrointestinal tract or respiratory system. Methods: This study aimed to measure serum concentrations LRP6, SFRP3, and DVL1 using ELISA method patients with NETs (N=80) control (N=62). We evaluated results against various demographic, clinicopathological, biochemical characteristics. Results: Our analyses revealed that concentration SFRP3 neuroendocrine was significantly elevated (p&amp;amp;lt;0.001)...

Introduction: Neuroendocrine tumors are a diverse group of predominantly found in the gastrointestinal tract or respiratory system. Methods: This retrospective study aimed to measure serum concentrations LRP6 (low-density lipoprotein receptor-related protein 6), SFRP3 (secreted frizzled-related 3), and DVL1 (segment polarity dishevelled homolog) using ELISA method patients with NETs (N = 80) control 62). We evaluated results against various demographic, clinicopathological, biochemical...

Streszczenie Sestryny to wysoce konserwatywne białka, które regulują wzrost, metabolizm, przeżycie i proliferację komórek w warunkach stresu oksydacyjnego, genotoksycznego, hipoksji czy retikulum endoplazmatycznego. wpływają na sygnalizację komórkową przez hamowanie wytwarzania reaktywnych form tlenu, aktywację kinazy białkowej aktywowanej AMP (AMPK), szlaku mTOR, a działają jako pozytywny regulator autofagii. W związku z tym coraz częściej wskazuje się ich rolę ochronną przed chorobami...

Objective: The objective of the study was to determine whether students take psychoactive substances during exam time and it affects their academic performance. assessment a subjective evaluation by student. purpose work also which are most popular among students, feel under pressure, in environment, produce best results. Method: An anonymous online survey about use conducted between November 1, 2017 March 31, 2018. It addressed Polish universities. In total 610 took part survey. More than...

Whipple’s disease is a rare, chronic systemic infection caused by gram-positive Tropheryma whipplei actinobacterium. So far, the reasons for have not been explained. Clinical symptoms are non-specific and may suggest other diseases, mainly gastrointestinal disease. Nervous system such as personality disorders, behavioral depressive disturbances of consciousness also observed. The aim study to collect information on neuropsychological disorders found in Central nervous (CNS) involvement can...