A silica-based mesoporous nanosphere (MSN) controlled-release drug delivery system has been synthesized and characterized. The uses L-cysteine derivatized gold nanoparticles (AuNPs), bound to the MSNs using Cu2+ as a bridging ion. AuNPs serve removable caps that hinder release of molecules inside amino functionalized MSN framework. modified themselves exhibit negligible cytotoxicity living cells, revealed 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. requires one...

A solution method for preparing surface functionalized colloidal silicon quantum dots (SiQDs) is presented. SiQDs prepared by this are reasonably monodispersed and can be further via thiol–ene click reactions to introduce specific functionalities (i.e. –NH2, –COOH, –SO3−, alkane, alkene).

Fluorescence lifetime imaging microscopy is successfully demonstrated in both one- and two-photon cases with surface modified, nanocrystalline silicon quantum dots the context of bioimaging. The technique further combination Förster resonance energy transfer studies where color nanoparticles tuned by using organic dye acceptors directly conjugated onto nanoparticle surface.

In this study, we describe a solution procedure for the preparation and surface modification of photostable colloidal silicon quantum dots (SiQDs) imaging cancer cells. Photoluminescent SiQDs were synthesized by reduction halogenated silane precursors using microemulsion process. It was shown that 1,8-nonadiyne molecules could be grafted onto hydrogen-terminated via ultraviolet (UV)-promoted hydrosilylation, demonstrated Fourier transform infrared spectroscopy (FTIR) measurements. addition,...

Detecting proteins in ultralow concentrations complex media is important for many applications but often relies on complicated techniques. Herein, a single-molecule protein analyzer with the potential high-throughput reported. Gold-coated magnetic nanoparticles DNA-labeled antibodies were used target recognition and separation. The immunocomplex was loaded into microdroplets generated centrifugation. Immuno-PCR amplification of DNA enabled quantification at level single molecules. As an...

Silver nanoparticles capped with mercaptoacetic acid and 2-aminoethanethiol short-chain alkanethiols were prepared by a one-step method in aqueous solution for monitoring pH range of heavy metal ions. The mode transduction is optical, based on the change aggregation solution. Because different ionic interactions between modified nanoparticles, these nanoparticle sensors can rapidly detect Pb(2+), Cu(2+) Fe(2+), detection limits as low 1 × 10(-5) M, 5 10(-7) M respectively, well having...

We experimentally demonstrate laser generation for the first time by using PbSe quantum dots (QDs) as lasing gain medium in an all-fiber ring resonator. The resonator is configured with QD-doped fiber (QDF), pumping diode, wavelength division multiplexer, Bragg grating, isolator, and coupler. An obvious excitation threshold up to several tens of milliwatts observed experiment upon 980-nm pump. only when this reached or exceeded, then output power increases linearly pump level. multimode QDF...

Herein, a pipette-tip-enabled digital nucleic acid analyzer for high-performance COVID-19 testing is demonstrated. This achieved by loop-mediated isothermal amplification (digital LAMP or dLAMP) using common laboratory equipment and materials. It shown that simply fixing glass capillary inside conventional pipette tips enables the generation of monodisperse, water-in-oil microdroplets with benchtop centrifugation. LAMP, ORF1a/b gene, standard test region screening, can be amplified without...

Increasing attention is paid to poly-adenine (poly-A) DNA-functionalized gold nanoparticles due the high cost of thiols. Freezing an effective approach for immobilizing poly-A DNA on nanoparticles, but its mechanism remains elusive. To cope with this issue, in paper, some experimental insights are provided. It shown that (1) loading density independent length poly-A. (2) densely packed and biointerface peculiarly stable, which not line existing "wrapping" model. (3) Using a DNA-staining dye,...

Single-molecule fluorescence microscopy is used to follow dynamic ligand reorganization on the surface of single plasmonic gold nanorods. Fluorescently labeled DNA attached nanorods via a gold–thiol bond using low-pH loading method. No activity initially observed from fluorescent labels nanorod surface, which we attribute collapsed geometry metal. Upon several minutes laser illumination, marked increase in observed, suggesting that shell reorganizes collapsed, quenched an upright, ordered...

The creation of multiple emission pathways in quantum dots (QDs) is an exciting prospect with fundamental interest and optoelectronic potential.

Herein is presented a proof-of-concept study of protease sensing that combines nontoxic silicon quantum dots (SiQDs) with Förster resonance energy transfer (FRET). The SiQDs serve as the donor and an organic dye acceptor. covalently attached to using peptide linker. Enzymatic cleavage leads changes in FRET efficiency. combination interfacial design optical imaging this work opens opportunities for use relevant intracellular imaging.

We describe an unsaturated gain-loss model in regards to colloidal PbSe quantum dot (QD)-doped fiber laser realized previously. Based on experimental observation the laser, numerical simulation indicates there exists a pumping threshold that depends QD doping concentration. There is defined range of concentration, within which can be generated. Available density length, following exponential decrease with increased length. Our suggests reasonable lifetime 100 ns for upper level QDs...

Abstract Gold nanorods (AuNRs) are an important class of advanced plasmonic materials, but unlike gold nanospheres (AuNSs) their surface modification is difficult due to the specific surfactant layer cetyltrimethylammonium bromide (CTAB) resulted from synthesis. In this paper, a freeze‐induced strategy proposed for AuNRs. Freezing AuNRs right after simple wash step can facilitate binding ligands and allow assembly functional biointerface in fast time scale. This simple, fast, versatile,...

Aluminum quantum dots (AlQDs) are an emerging class of optical material due to their unique photoluminescence in the ultraviolet waveband. Herein, a strategy is presented control emission. The synthesized AlQDs displayed from UV-B region (<320 nm) near-ultraviolet (∼425 and high yields. Our investigation revealed that surfactants phosphonic acids (PAs) were competitively bound surface AlQDs, this was affected by space volume charge head groups. steady-state time-resolved spectroscopic data...

Abstract Metal nanoclusters with distinct photophysical and photochemical properties have drawn intense research interests for their applications in optoelectronics, catalysis, biomedicine. Herein, strong evidence is provided that light metal capable of generating comparable optical responses noble nanoclusters, but at much shorter wavelength. Air‐stable, size‐uniform, sub‐3 nm aluminum nanocrystals are prepared simple solution based synthetic procedures, photoluminescence located the...