A5061387640- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Insect and Pesticide Research
- Biochemical effects in animals
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Ocular Surface and Contact Lens
- Phytochemistry Medicinal Plant Applications
- Phytochemistry and biological activity of medicinal plants
- Muscle metabolism and nutrition
- Biofield Effects and Biophysics
Bee Research Institute
2019-2024
Tottori University
2021-2022
Nutrasource
2021
Melinjo (Gnetum gnemon L.) seeds are rich in resveratrol (RES) and its dimers, gnetin C gnemonoside A. They have various pharmacological benefits, antioxidant anti-inflammatory properties; however, their pharmacokinetics, especially animal models, must be better understood. This study aimed to elucidate the pharmacokinetics of melinjo seed extract (MSE) components rats. Plasma samples were collected up 24 h after intergastric administration MSE (1000 mg/kg), C, or A (51 μmol/kg each). RES...
The unique fatty acids in royal jelly (RJ), 10-hydroxy-2-decenoic acid and 10-hydroxydecanoic are expected to be associated with many health benefits, but little is known on the pharmacokinetics metabolism. aim of this study confirm metabolism RJ humans. Twelve volunteers received capsules or enzyme treated (ETRJ) (800 mg). other group two doses ETRJ tablets mg 1600 Plasma samples were collected up 12 h after intake urine within 24 tablet consumption. analyzed by LC/MS/MS. A multivariate...
A new cinnamic acid derivative, (E)-3-[4-hydroxy-3-((E)-3-formyl-2-butenyl)phenyl]-2- propenoic (20) has been isolated from the ethanol extract of Brazilian green propolis along with three known derivatives, 3,4-dihydroxy-5-prenyl-(E)-cinnamic (4), capillartemisin (6), and 2,2-dimethylchromene-6-(E)-propenoic (8), a flavonoid, dihydrokaempferide (16) by liquid–liquid participation, series column chromatography preparative HPLC. Their structures have determined spectroscopic analyses chemical...
Prenylated cinnamic acid derivatives are the bioactive components of Brazilian green propolis (BGP). The effect other botanical on pharmacokinetic profiles these remains relatively unexplored. In present study, we investigated influence several herbal extracts (turmeric, ginkgo leaf, coffee fruit, soybean, and gotu kola) plasma concentrations after BGP consumption. When were co-administered with in clinical area under curve (AUC) values artepillin C drupanin, major plasma, significantly...
Phenolic glucuronides of artepillin C and drupanin were identified as the major metabolites in plasma after ingestion Brazilian green propolis.
Cinnamic acid derivatives, which are dietary phenolic compounds, attracting attention for their health benefits. Artepillin C, drupanin, baccharin, and p-coumaric major cinnamic derivatives in Brazilian green propolis (BGP) used as functional food materials. To investigate the metabolism of these each compound was administered to rats, metabolic profiles were compared with those BGP. C is metabolized hydroxylated metabolites (capillartemisin A), well glucuronide. Drupanin sulfate,...
The cough-suppressing effect of honey was demonstrated for the first time using a guinea pig model whereby cough induced by citric acid and capsaicin, new pyrrolyl pyridoindole, 1-(5-(hydroxymethyl)-1H-pyrrol-2-yl)-9H-pyrido[3,4-b]indole-3-carboxylic (1), named melpyrrole, flazin (2) were identified as active principle components. structures 1 2 estimated combination approach an activity-guided survey LC-MS/MS multivariate analysis finally established total synthesis comparison with...
Dry eye is a multifactorial disease characterized by ocular discomfort and visual impairment. Our previous studies have shown that royal jelly (RJ) has restored the capacity for tear secretion modulating muscarinic calcium signaling. RJ contains acetylcholine, which major cholinergic neurotransmitter, unique set of fatty acids with C 8 to 12 chains, are expected be associated health benefits. The purpose present study was investigate active components involved in capacity, focusing on...