Chunhui Zeng

ORCID: 0000-0003-0910-5178
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Research Areas
  • Streptococcal Infections and Treatments
  • Gout, Hyperuricemia, Uric Acid
  • Bacterial biofilms and quorum sensing
  • biodegradable polymer synthesis and properties
  • Antimicrobial Resistance in Staphylococcus
  • 3D Printing in Biomedical Research
  • Inflammasome and immune disorders
  • Medicinal plant effects and applications

Guangxi University of Chinese Medicine
2022-2024

Guangxi University
2023

Ethnopharmacological relevance Choerospondias axillaris (Roxb.) Burtt et Hill (CA) is a medicinal and edible plant fruit with national characteristics in China. CA commonly used folk medicine for treating kidney diseases, heart calming the mind. Modern pharmacological studies have demonstrated that exhibits effects such as protection against renal injury, antioxidation, anti-inflammation, calcium antagonism. Objective This study aimed to explore mechanism of stones through network...

10.3389/fphar.2025.1501386 article EN cc-by Frontiers in Pharmacology 2025-04-16

Abstract In the disease gout, monosodium urate (MSU) crystals nucleate in joints and cause acute painful arthritis that can damage affected joints. Similarly, deposition of other or irritant particles tissues elicits an inflammatory response disease. These various stimulate macrophages to produce proinflammatory cytokine interleukin 1β (IL-1β), which is a major driver ensuing inflammation. Here we show vivo vitro, broad spectrum cathepsin inhibitors, like VBY-825, blocked activation...

10.1101/2024.07.01.601464 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-07-03

Staphylococcus aureus is a prevalent cause of lung infections in hospitals and communities, can wide spectrum human infections. Due to the bottleneck caused by antibiotic resistance substantial increases morbidity mortality, targeting virulence factors released S. as an alternative prevention treatment method has become promising approach. Ampelopsin, component vine tea, potential for treating aureus-induced acute injury. In this study, effects ampelopsin were investigated on mouse model...

10.1016/j.micpath.2023.106316 article EN cc-by-nc-nd Microbial Pathogenesis 2023-08-25

Ethnopharmacological relevance: Polygonum multiflorum Thunb. (PM) is a Chinese herbal medicine. The processed PM (PPM) was by raw (RPM) with black bean juice, using the 'nine-steaming and nine-sun-curing' medicine processing method. After processing, efficacy of RPM changed. Many studies have reported on use to improve Alzheimer’s disease (AD), but there lack research this aspect PPM.Aim Study: This study aimed investigate effect degree PPM improving AD.Materials Methods: Wild-type (WT)...

10.2139/ssrn.4041781 article EN SSRN Electronic Journal 2022-01-01
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