Abstract Objective The aim of this case-control study was to assess the efficacy dapagliflozin combined with metformin for type-2 diabetes mellitus (T2DM) obstructive sleep apnea hypopnea syndrome (OSAHS). Methods A total 36 patients newly-diagnosed T2DM and OSAHS were randomized divided into two groups. Eighteen T2DM, who treated metformin, assigned as group. These given 24 weeks between February 2017 2018. Another 18 glimepiride weeks, control Fasting plasma glucose (FPG) level,...

BACKGROUND Our study aimed to explore the levels of nerve growth factor (NGF) and brain derived neurotrophic (BDNF) in healthy participants, type 2 diabetes mellitus (T2DM) patients, diabetic peripheral neuropathy (DPN) patients order find their effects on DPN. MATERIAL AND METHODS The clinical data 110 participants (age: 57.3±8.2 year, height: 165.4±5.5 cm, weight: 64.1±7.5 kg), 83 T2DM 56.5±7.9 164.8±6.2 63.6±6.6 65 DPN 58.2±7.3 166.7±6.7 63.1±5.8 kg) were observed. ELISA was applied...

The potential etiological and diagnostic values of the gut microbiota in children with neurodevelopmental disorders are encouraging but controversial. In particular, composition characteristics autism spectrum disorder (ASD) attention deficit hyperactivity (ADHD) remain largely unidentified. Herein, we analyzed stool samples from 113 participants a clinical diagnosis ASD, 43 ADHD, 8 both ASD 120 healthy controls between 2 11 years age using 16S rRNA sequencing. We observed that diagnosis,...

Background. Visfatin/PBEF/Nampt is an adipose-derived hormone proposed to exert insulin-mimicking effects and play a positive role in attenuating insulin resistance. However, the precise mechanisms underlying beneficial of visfatin/PBEF/Nampt on sensitivity remain unknown.

Background: Type 2 diabetes mellitus (T2DM) is strongly correlated with Alzheimer's disease (AD). Rapamycin has important uses in oncology, cardiology and transplantation medicine. This study aims to investigate effects of rapamycin on AD hippocampus T2DM rat by AMPK/mTOR signaling pathway.Methods: Morris water maze test was applied evaluate the learning memory abilities. The fasting plasma glucose (FBG), glycosylated haemoglobin, total cholesterol, triglyceride serum insulin level were...

Diabetes mellitus (DM) is a systemic metabolic disease. Tanshinone IIA (Tan‑IIA) presents potential benefits for DM. The purpose of this study was to investigate the efficacy Tan‑IIA in type 2 DM rats and explore its mechanism renal cells. A rat model established administered with or PBS. It demonstrated that treatment significantly reduced levels total cholesterol, non‑esterified fatty acids, triglyceride low‑density lipoprotein cholesterol experimental compared control group. results...

Alzheimer disease (AD) has been recognized as a progressive neurodegenerative disorder. This study aims to investigate the effects of estrogen receptor α (ERα) gene promoter methylation on cognitive function and quality life (QOL) patients with AD.A total 132 AD 135 healthy individuals were recruited for this study. The DNA in peripheral blood was extracted treated bisulfite; then methylation-specific polymerase chain reaction reverse transcription quantitative performed determine status ERα...

Abstract Diabetes is associated with neurological complications, and accumulated evidence shows that biological pathways in diabetes are targeted by noncoding RNA transcripts. In this study, the role of long intergenic (lincRNA) p21/microRNA‐221 (miR‐221)/fructooligosaccharide (FOS) axis was investigated mice treatment. The streptozotocin‐induced diabetic mouse model established. learning ability pathological changes were analyzed. After that, interaction among miR‐221, lincRNA p21, FOS...

Background: Frailty is a common biological syndrome in elderly people, and the aging process regulates thyroid function. The present study aimed to determine prevalence of frailty an older inpatient cohort using FRAIL scale evaluate association with hormone levels.

In the quest to address critical shortage of donor organs for transplantation, xenotransplantation stands out as a promising solution, offering more abundant supply organs. Yet, its widespread clinical adoption remains hindered by significant challenges, chief among them being immunological rejection. Central this issue is role complement system, an essential component innate immunity that frequently triggers acute and chronic rejection through hyperacute immune responses. Such responses can...

Type 2 diabetes mellitus (T2DM) is a long‑term metabolic disorder characterized by high blood sugar levels, insulin resistance and relative lack of insulin. A previous study has reported that an association exists between γ‑aminobutyric acid (GABA) the hippocampus. The current therefore aimed to assess effect GABA receptor (GABA‑R) on potentiation (LTP) depotentiation hippocampal CA1 region in mice with T2DM. Mice were divided into four groups: normal group consisting healthy GABA‑R,...

Systemic lupus erythematosus (SLE) is an autoimmune disease of uncertain etiology that affects multiple tissues and organs. Arsenic trioxide (ATO) has been used in lupus-prone mice with a regulatory effect on immune abnormality. Tetra-arsenic tetra-sulfide (As 4 S ), traditional Chinese medicine, effective acute promyelocytic leukemia mild side effects than ATO. In this study, pilot study was performed to investigate the mechanism As BXSB mice. Improvement monocytosis ( p < 0.05) spleen...

Recently, the incidence of thyroid cancer (THCA) has been on rise. RNA binding proteins (RBPs) and their abnormal expression are closely related to emergence pathogenesis tumor diseases. In this study, we obtained gene data corresponding clinical information from TCGA database. A total 162 aberrantly expressed RBPs were obtained, comprising 92 up-regulated 70 down-regulated RBPs. Then, performed a functional enrichment analysis constructed PPI network. Through univariate Cox regression key...

1. The ferritin heavy chain (FHC) has a vital impact on follicular development in geese, due to its ability regulate apoptosis of granulosa cells (GCs) and atresia. However, specific regulatory mechanisms remain unclear. present study characterised how FHC regulates oxidative stress, cell proliferation goose GCs by interfering with overexpressing the

To investigate the clinicopathological features, molecular genetic and differential diagnosis of intraductal carcinomas (IDC) salivary glands.

Emerging evidence suggests that the bactericidal/permeability-increasing protein (BPI) is involved in process of cognitive impairment diabetes. However, its underlying mechanism remains elusive. In this study, we found BPI affects due to diabetes through lipopolysaccharide (LPS)-lipopolysacharide-binding (LBP)-toll-like receptor 4 (TLR4) signaling pathway. We examined expression BPI, LPS, LBP, CD14, and TLR4 established mouse models induced by high-fat diet (HFD) combination with...

Abstract Objective This meta-analysis was conducted to explore the relationship between serum level of IL-8 and obstructive sleep apnea syndrome (OSAS). Methods Electronic databases were retrieved according inclusion exclusion criteria, relevant studies exploring OSAS enrolled. Statistical analysis performed using STATA 12.0. Results Totally 199 retrieved, among which 10 qualified for criteria finally included in with 367 cases patients 335 control cases. Serum higher than healthy controls...

Multiple statin-associated muscle symptoms (SAMS) risk factors usually coexist in a given older diabetic patient, but the association between statin use and physical function Asian persons with T2MD remains uncertain. The present study therefore sought to provide insight into this uncertainty through focused assessment of outcomes Chinese adults.

Objective: To evaluate the diagnosic performance of a novel Mycobacterium tuberculosis (MTB) specific T-cell based assay for tuberculosis, which targets mRNA detection interferon gamma-induced protein 10 (IP-10). Methods: Suspected patients were prospectively and consecutively recruited in Beijing Chest Hospital between March 2018 November 2019, individuals with lower risk MTB infection also recruited. IP-10.TB T-SPOT.TB assays simulataneously performed on peripheral blood samples. The...