A5078738273- Lung Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Electron Spin Resonance Studies
- Advanced NMR Techniques and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cardiac Imaging and Diagnostics
- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Esophageal and GI Pathology
- CAR-T cell therapy research
- Soft tissue tumor case studies
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Solid-state spectroscopy and crystallography
- Management of metastatic bone disease
- Childhood Cancer Survivors' Quality of Life
- Integrated Circuits and Semiconductor Failure Analysis
- Ultrasound and Hyperthermia Applications
- Cardiovascular Function and Risk Factors
University of Southern California
2025
The University of Texas Southwestern Medical Center
2018-2023
Southwestern Medical Center
2022-2023
A significant subset of patients with stage II/III non-small cell lung cancer (NSCLC) cannot receive standard concurrent chemoradiotherapy owing to the risk toxic effects outweighing potential benefits. Without chemotherapy, however, efficacy conventional radiotherapy is reduced.To determine whether hypofractionated image-guided (IGRT) would improve overall survival in NSCLC who could not and therefore were traditionally relegated receiving only conventionally fractionated (CFRT).This...
Integration of hypofractionated body radiotherapy (H-RT) into immune checkpoint inhibitor (ICI) therapy may be a promising strategy to improve the outcomes ICIs, although sufficient data is lacking regarding safety and efficacy this regimen. We, hereby, reviewed combination in 59 patients treated with H-RT during or within 8 weeks ICI infusion compared results historical reports treatment alone. Most had RCC melanoma. Median follow-up was 11 months. received either Nivolumab alone...
Total body irradiation is an important part of the conditioning regimens frequently used to prepare patients for allogeneic hematopoietic stem cell transplantation (SCT). Volumetric-modulated arc therapy enabled total (VMAT-TBI), alternative conventional TBI (cTBI), a novel radiotherapy treatment technique that has been implemented and investigated in our institution. The purpose this study (1) report six-year clinical experience terms planning strategy delivery time (2) evaluate outcomes...
A 33-year-old man with no history of smoking or unusual exposures presented worsening cough unresponsive to several rounds antibiotics. His chest computed tomography (CT) revealed widespread centrilobular nodules in all pulmonary lobes a confluence the right middle and lower lobes, causing atelectasis (Fig. 1). Bronchoscopic biopsy performed February 2006 well-differentiated adenocarcinoma lung lepidic growth pattern. Fluorodeoxyglucose F 18 (FDG)–positron emission tomography-CT nodal...
Although single-institution series suggest potential benefit to dose escalation in definitive radiation therapy for esophageal cancer, randomized trials including intergroup-0123 and the recently presented A Randomized Trial of Dose Escalation Chemoradiotherapy patients with Oesophageal cancer (ARTDECO) trial showed no improvement outcomes higher dose. As such, there may be significant variation treatment cancer.The National Cancer Database was used identify who received a diagnosis...
Abstract Background: Approximately 50% of all cancer patients receive radiation therapy as a component their care. While has demonstrable benefit in improving survival patients, radiation-induced heart disease (RIHD) is major contributor to morbidity and mortality survivors with history thoracic radiation. Understanding metabolic changes underlying RIHD may enable development novel diagnostic therapeutic approaches for early detection treatment RIHD. The high energetic demands the require...
Abstract Background: Nearly half of all patients receive radiation therapy as a component their cancer care. Despite the efficacy treatment, cardiotoxicity is major concern in receiving chest radiotherapy. There are currently no standardized approaches for early detection radiation-induced stage that offers potential intervention. In this study, we employ hyperpolarized 13C- pyruvate magnetic resonance spectroscopy to non-invasively characterize metabolic changes heart response radiation....
Radiation-induced heart disease is a major source of morbidity and mortality in patients receiving thoracic radiation. In this study, radiation-induced changes cardiac metabolism investigated using hyperpolarized [1- 13 C]pyruvate MRI animals patients. Myocardial bicarbonate-to-lactate ratios decreased following radiation treatments while no change was observed the global strain, suggesting mitochondrial dysfunction heart. This translational study demonstrates clinical potential C pyruvate...