A5103046129- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Biochemical Acid Research Studies
- Vascular Malformations and Hemangiomas
- Histiocytic Disorders and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Metabolism and Genetic Disorders
- Sarcoma Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Cardiac tumors and thrombi
- T-cell and Retrovirus Studies
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Disorders and Syndromes
- Gastrointestinal Tumor Research and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Platelet Disorders and Treatments
- Protein Degradation and Inhibitors
- Cardiac Imaging and Diagnostics
- Soft tissue tumor case studies
- Chronic Lymphocytic Leukemia Research
- Cardiac Arrhythmias and Treatments
Japanese Red Cross Society Wakayama Medical Center
2016-2025
Komatsu (Japan)
2016-2022
Hitachi (Japan)
2020
Boramae Medical Center
2019
Seoul National University
2019
Wakayama Medical University
2005-2013
Kobe Tokiwa University
2007
Shiga Medical Center for Adults
2006
Shiga Medical Center
2006
Fukushima Medical University
2001-2003
We analyzed 14 cases of new lesions inside implanted bare-metal stents. In every case, there was no angiographic restenosis within 3 years, but a lesion observed stented segment at long-term follow-up (>5 years). Fourteen were evaluated: 9 with Wiktor stents, 2 Palmaz-Schatz and ACS Multilink The interval from stent implantation to angiography 63-147 months (89 +/- 23). Thirteen treated by percutaneous coronary intervention (PCI) stenotic tissue obtained directional atherectomy (DCA) in 10...
We report five serial cases of ciliated muconodular papillary tumor (CMPT) the lung. CMPT is characterized as a low-grade malignant with columnar epithelial cells combined goblet cells, typically presenting peripheral lung and often causing diagnostic or therapeutic problems. In described here, all patients presented abnormal chest shadow but no definitive symptoms. Although tumors were peripheral, computed tomography (CT) revealed various radiographic findings including small nodules,...
While Annealing Machines (AM) have shown increasing capabilities in solving complex combinatorial problems, positioning themselves as a more immediate alternative to the expected advances of future fully quantum solutions, there are still scaling limitations. In parallel, Graph Neural Networks (GNN) been recently adapted solve showing competitive results and potentially high scalability due their distributed nature. We propose merging approach that aims at retaining both accuracy exhibited...
Abstract The co-occurrence of JAK2 V617F mutations and the BCR::ABL1 translocation in same patient is rare, current standard treatment for aggressive myeloid blast phase chronic leukemia (CML-myeloid BP) with remains inadequate, particularly transplant-ineligible patients. Asciminib, a first-in-class allosteric inhibitor kinase that specifically targets ABL1 myristoyl pocket, has emerged as novel alternative to tyrosine (TKI) therapy. Ropeginterferon alfa-2b (ropegIFNα2b) site-selective,...
Aims α-Fetoprotein (AFP)-producing gastric carcinoma (AFPGC) is one of the most aggressive GC subtypes. Frequent expression human epidermal growth factor receptor 2 (HER2) has previously been reported in hepatoid adenocarcinoma (HAC), a major histological subtype AFPGC originating from common-type (CGC). However, HER2 levels other subtypes are unknown. In this study, we analysed GCs with primitive phenotypes addition to HAC. Methods was evaluated representative complete sections 16 HACs, 19...
To clarify the cellular differentiation features and facilitate diagnosis of angiomatoid (malignant) fibrous histiocytoma (AFH), four cases AFH were examined by clinicopathologic, immunohistochemical ultrastructural analyses. The age patients ranged from 10 to 24 years (mean, 17 years) sex distribution was equal. All subcutaneous origin: three arose in trunk one upper extremity. presented with systemic symptoms, including inflammatory signs anemia. After a mean follow up 11 3 months, all...
Abstract We herein report a case of methotrexate‐associated lymphoproliferative disorder (MTX‐LPD) showing fibrin‐associated large B‐cell lymphoma‐like heart valve lesions, and Epstein‐Barr virus (EBV)‐positive mucocutaneous ulcer‐like cutaneous oral mucosal lesions. MTX‐LPD is critical complication that can occur in RA patients who are treated with MTX. EBV also plays defining or important role LPDs. Among the sites MTX‐LPD, 40−50% extranodal sites, including gastrointestinal tract, skin,...
Two cases of 8p trisomy in one sibship are presented. The father was a balanced carrier translocation rep (8;13) (p11; q34). Case 1 2‐year‐old boy with multiple minor anomalies and severe mental retardation. Giemsa banding studies revealed that he trisomic for the greater part (8p11 → pter). When his mother became pregnant again, amniocentesis carried out 17th week gestation. fetus (Case 2) shown to have same as 1. pregnancy terminated 22nd week. An autopsy no major anomalies. Clinical...
Solid papillary carcinoma (SPC) of the breast is a rare cancer that accounts for less than 1% all cancers. The optimal clinical management SPC remains controversial. Here, we report case invasive with neuroendocrine differentiation in addition to review current literature.A premenopausal 46-year-old female presented mass her left tended increase size over 10-month period. Mammography and ultrasonography revealed upper-inner quadrant. resulting images suggested category 3 tumor according...
Although treatments for adult T-cell leukemia/lymphoma in the past two decades have advanced, current standard treatment aggressive leukemia/lymphoma, particularly patients who are not eligible stem cell transplantation, remains inadequate; therefore, to prolong duration of remission and provide relevant benefits terms survival quality life needed. Adult tumor cells express CD30 some cases increased expression is considered be one causes constitutive NF-κB activation cells. Brentuximab...
Adult T cell leukemia/lymphoma (ATL) is incurable with conventional chemotherapies, and allogeneic stem transplantation (SCT) the only curative treatment. Direct antitumor effects immune responses are important factors that need to be considered in treatment of ATL. A phase II study reported long overall survival despite short progression-free patients, implying lenalidomide confers a benefit through immunomodulation for patients We herein report low-dose as maintenance therapy maintained...
Intravascular large B-cell lymphoma (IVLBCL) is a rare type of aggressive extranodal characterized by the selective growth cells within lumina blood vessels, particularly capillaries. IVLBCL lacks mass formation, and its diagnosis can be challenging. We analyzed utility insulin-like factor II mRNA-binding protein 3 (IMP3) immunohistochemistry for in various organs. Double staining with paired box 5 (PAX5) was performed validation. Overall, 152 pathological specimens (111 positive 41 negative...
The binding of the pyruvate dehydrogenase (E1) component and E1-specific kinase to core-forming dihydrolipoyl acetyltransferase (E2) facilitates a severalfold enhancement in rate at which phosphorylate E1 (i.e. versus free phosphorylating E1). associate with small exterior linker region-connected domains E2 structure. binds one two lipoyl domains, domain E2s structure between region inner domain. Sixty latter assemble form dodecahedron-shaped core. Binding detached enhanced activity. This...
We present a case of perivascular epithelioid cell tumor (PEComa), which clinically and histologically mimics gastrointestinal stromal (GIST). A 42-year-old woman was found to have mass in the left flank during her annual medical checkup. Computed tomography examination revealed submucosal descending colon. Surgeons radiologists suspected that lesion GIST, hemicolectomy performed without biopsy. Microscopic showed composed spindle cells, were immunohistochemically negative for c-kit positive...
Key Clinical Message Although the clinical significance of hypothyroidism in TAFRO syndrome is unknown, vascular endothelial growth factor (VEGF) levels decreased with improvements condition our refractory cases after thyroxine supplement therapy. Our results indicate that elevated VEGF are a potential pathogenesis and anasarca hypothyroidism.
// Yusuke Takei 1,* , Chiyuki Ueshima Tatsuki R. Kataoka Masahiro Hirata 1 Akihiko Sugimoto Mariyo Rokutan-Kurata Koki Moriyoshi 1,2 Kazuo Ono 3 Ichiro Murakami 4 Sanju Iwamoto 5 and Hironori Haga Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan 2 Medical Center, Red Cross Society Wakayama Wakayama, School Medicine, Kochi Faculty Nankoku, Pharmacology, Toxicology & Therapeutics, Division Physiology Showa Pharmacy, Tokyo, * These authors have equally contributed to...
A relationship has been reported between myelodysplastic syndrome (MDS) and autoimmune disease. Behçet's disease is a multisystem inflammatory disorder with mucocutaneous, articular, gastrointestinal, neurological, vascular manifestations. The co-occurrence of MDS trisomy 8 Behçet's-like was recently demonstrated. We herein describe case that shows the acquisition occurrence Immune dysregulation altered T-cell hemostasis play an important role in pathogenesis 8.