A5029074453- Gastrointestinal Tumor Research and Treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Neurofibromatosis and Schwannoma Cases
- Chronic Myeloid Leukemia Treatments
- Tracheal and airway disorders
- Parathyroid Disorders and Treatments
- Appendicitis Diagnosis and Management
- Renal cell carcinoma treatment
- Cancer survivorship and care
- Chronic Lymphocytic Leukemia Research
- Abdominal vascular conditions and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Cancer Genomics and Diagnostics
- Otolaryngology and Infectious Diseases
- Metastasis and carcinoma case studies
- Aortic aneurysm repair treatments
- Gallbladder and Bile Duct Disorders
Shonan Kamakura General Hospital
2011-2024
Teikyo University
2024
Weatherford College
2021
Murata (Japan)
2021
National Cancer Center Hospital East
2004-2020
Japanese Red Cross Society Wakayama Medical Center
2015-2017
Sapporo Medical University
2009
Hyogo Medical University
2009
Niigata University
2009
Osaka University
2009
We report five serial cases of ciliated muconodular papillary tumor (CMPT) the lung. CMPT is characterized as a low-grade malignant with columnar epithelial cells combined goblet cells, typically presenting peripheral lung and often causing diagnostic or therapeutic problems. In described here, all patients presented abnormal chest shadow but no definitive symptoms. Although tumors were peripheral, computed tomography (CT) revealed various radiographic findings including small nodules,...
Abstract Background Pre-operative kidney function is known to be associated with surgical outcomes. However, in emergency surgery, the pre-operative may reflect chronic disease (CKD) or acute injury (AKI). We examined association of CKD and/or AKI in-hospital outcomes colorectal surgery. Methods conducted a retrospective cohort study including adult patients undergoing surgery 38 Japanese hospitals between 2010 and 2017. classified into five groups according status (defined as baseline...
Surgery is the most effective treatment for early-stage lung cancer; however, it poses a higher physical burden than other options. Therefore, understanding perioperative course of patients important. Using Short Form Health Survey 36, we prospectively measured quality life who underwent anatomical pulmonary resection non-small cell cancer at Shonan Kamakura General Hospital, Kanagawa, Japan (n = 87). In preoperative setting, had lower performance status and lived alone significantly worse...
Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are powerful molecular targeted therapeutic agents for lung cancer. We recently developed an original immunocytology and glass slide-based circulating tumor cell (CTC) detection platform both CTC enumeration EGFR mutation analysis with DNA extracted from CTCs. Methods: Using this platform, we conducted a pilot clinical study in peripheral blood (PB), pulmonary arterial (PA), venous (PV) 33 patients cancer (Stage...
The short-term efficacy of virtual-assisted lung mapping (VAL-MAP), a preoperative bronchoscopic multi-spot lung-marking technique, has been confirmed in 2 prospective multicentre studies. objectives this study were to analyse the local recurrence and survival patients enrolled these studies, long-term.Of 663 559 patients' follow-up data collected. After excluding those who did not undergo VAL-MAP, whose resection was for curative intent, underwent concurrent without or eventually lobectomy...
10015 Background: Patients with GIST resistant to both imatinib (IM) and sunitinib (SU) have a poor prognosis few therapeutic options. The objective of this study is investigate efficacy safety nilotinib as third line therapy for Japanese pts who shown resistance and/or intolerance sunitinib. Methods: A single arm, open-label trial was conducted in 8 hospitals Japan. key eligibility criteria included histologically confirmed KIT-positive progression on or treatment. Pts were treated 400 mg...
Bleeding in the small bowel rarely occurs, and its treatment is challenging. Surgery sometimes required unstable patients; however, intraoperative identification of bleeding site extremely difficult. Many methods have been reported, but no standard strategy has established yet. Here, we aimed to assess safety feasibility angiography with indocyanine green staining accurately identify sites.This retrospective study analyzed contrast-enhanced computed tomography images patients (n = 8)...
Several large-scale studies have assessed the endovascular and surgical treatments for nonocclusive mesenteric ischemia (NOMI); nonetheless, prognostic factors NOMI remain unclear.In this single-center study, we retrospectively reviewed electronic medical records of 197, 149 patients were retrieved from inpatient database our hospital January 2011 to 2020; 79 with observed. A total 44 who underwent laparotomy statistically analyzed divided into survivor non-survivor groups. Prognostic...
Background: Several large-scale studies have assessed endovascular and surgical treatment methods for nonocclusive mesenteric ischemia (NOMI); however, the prognostic factors NOMI remain unclear. Therefore, this study aimed to evaluate risk in-hospital mortality among patients with who underwent laparotomy examine therapeutic strategies that may improve prognosis. Materials Methods: In multicenter retrospective study, we reviewed electronic medical records retrieved from inpatient database...
Abstract Background Precision medicine in non-small cell lung cancer requires attainment of a sufficient amount high-quality tumor tissue. Transbronchial cryobiopsy has emerged as new diagnostic method for non-neoplastic disease with better potential to assess morphology compared conventional methods. However, the influence on specimen quality, particularly detection protein expression, is unknown. We performed comparative immunohistochemical study specimens obtained by versus sampling...
4078 Background: STI 571, (Gleevec), is a specific inhibitor of BCR-ABL, c-kit, and PDGFR tyrosine kinases. After demonstration efficacy against KIT- positive GISTs, STI571 was approved for the treatment GISTs in US EU. This Phase II open-labelled, multicenter trial investigated efficacy, tolerability, PK Japanese pts with unresectable and/or metastatic malignant GISTs. Methods:The inclusion criteria were KIT-positive measurable lesions, adequate organ function, PS (ECOG)of 0–2, life...
10064 Background: This retrospective non-randomized study investigated the effect on survival of imatinib (IM) plus best supportive care (BSC) after IM and sunitinib (SU) treatment for pts with locally advanced or metastatic gastrointestinal stromal tumor. Methods: 39 who had previously been exposed to both SU were refractory intolerant their latest therapy regimen enrolled in this study. 13 excluded due participating clinical trials. 26 included Treatment was BSC either without (400mg/day...
We report here a rare case of primary hyperparathyroidism that was associated with an ectopic parathyroid adenoma located in the mediastinum. A 66-year-old woman suffering from had been followed-up on outpatient basis for over 10 years. She suffered persistent urolithiasis and osteopenia due to hypercalcemia. After technetium-99-sestamibi (99mTc-MIBI) scintigraphy revealed superior mediastinum, thoracoscopic resection tumor performed. Subsequently, her serum hormone (PTH) level decreased...
The Nuss procedure is currently the mainstream of pectus excavatum (PE) surgery; however, it considered to be more difficult for asymmetric cases than symmetric ones. Sternocostal elevation (SCE), which was performed at our hospital, a surgical method that determines extent resection costal cartilage while comparing left and right balance during thus, highly useful correcting rib cage with strong asymmetry.
Several methods can be used to intraoperatively identify pulmonary lesion using radiation technology. However, little is known about patient exposure during chest surgery. We aimed measure patients' from cone-beam computed tomography (CBCT) in a hybrid operating room. This retrospective study included patients who underwent surgical treatment room between April 2019 and December 2023 at the Teikyo University Hospital. All data was obtained prospectively, but approved by IRB as because of...
Bilateral empyema is a rare and severe condition deciding on treatment quite difficult. Additionally, infections caused by group A Streptococcus (GAS [Streptococcus pyogenes]) are known to be invasive. We successfully treated without surgery previously healthy 59-year-old woman with bilateral due GAS, repeated drainages, antibiotics, fibrinolytic therapy. To our knowledge, there have not been any published reports cases of GAS infection. In rare, organisms such as physicians managing the...
10560 Background: KIT or PDGFRA mutations are found in gastrointestinal stromal tumors (GIST) and correlated with imatinib (IM) effects. Most reports studied only hot-spots of each gene using paraffin sections extracted DNA. Here we examined full sequence the genes frozen section GI mesenchymal tumors. Methods: Histologic Dx was done HE immunohistochemistory (IH). Using RNA obtained from fresh samples serial 209 pts GIST (n=174), myogenic (21), neurogenic (11), sarcoma (3), cDNA amplified by...
Ehlers-Danlos症候群（EDS）はコラーゲンやその修飾酵素の遺伝子異常により結合組織脆弱性を来す遺伝性疾患群である．血管型EDSはIII型コラーゲン遺伝子変異により動脈や管腔臓器，肺が脆弱化し突然の破裂を来す常染色体優性疾患であり，EDSのうちで最重症とされる．今回我々は，死後に血管型EDSの確定診断がついた1例を報告する．症例は60代男性で，左気胸，腸管穿孔と3回の腹部動脈瘤破裂歴があった．胸痛を主訴に救急外来を受診し，右多発肋間動脈瘤破裂に伴う血胸と大量喀血を認めた．動脈塞栓術により活動性出血を停止させ，開胸血腫除去術により気道出血を停止させた．しかし，右心不全増悪により29病日に死亡した．死亡直前に皮膚生検と採血を行い，専門機関にて血管型EDSの確定診断を得た．動脈瘤破裂，消化管穿孔，血気胸の既往があれば，血管型EDSの可能性を考慮し，その特徴を踏まえた迅速な対応が必要になる．
e20501 Background: Size, mitosis and locus are important for risk stratification of gastrointestinal stromal tumors (GIST). Genotype cell cycle suggested related to aggressiveness progression, considered have prognostic impact, although most reports analyzed expression proteins or mRNAs. In this study, we examined the biological values CDK activities in primary GIST with R0 surgery. Methods: Histologic Dx was done HE IH. Using lysate frozen materials from 76 pts (n=70), leiomyoma (2),...
e15133 Background: In Japan, sunitinib malate (SUTENT) was approved in April 2008 for unresectable or metastatic RCC and GIST. As recommended by the Japanese Ministry of Health Labor Welfare guidance, we conducted an all-cases PMS to further evaluate safety following its approval Japan supplement information already available this agent. We report here interim results from 1,027 patients (773 with 254 GIST). Methods: All were examined eligibility registered study before initial treatment...
The incidence of acute empyema has increased in various countries; some elderly patients with have contraindications for surgery under general anesthesia. Therefore, suitable management based on a patient's clinical condition is required.We evaluated the different surgical and nonsurgical therapeutic approaches available empyema. This was retrospective study 57 who received treatment our department between May 2015 February 2019. For did not initially improve drainage or combined...