A5055857436- Effects and risks of endocrine disrupting chemicals
- Estrogen and related hormone effects
- RNA and protein synthesis mechanisms
- Immunotoxicology and immune responses
- PI3K/AKT/mTOR signaling in cancer
- Advanced biosensing and bioanalysis techniques
- Hormonal Regulation and Hypertension
- RNA modifications and cancer
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Cholesterol and Lipid Metabolism
- Helicobacter pylori-related gastroenterology studies
- S100 Proteins and Annexins
- Connective tissue disorders research
- Phagocytosis and Immune Regulation
- Adipose Tissue and Metabolism
- Inflammatory mediators and NSAID effects
- RNA regulation and disease
- DNA and Nucleic Acid Chemistry
- Pesticide Exposure and Toxicity
- Alzheimer's disease research and treatments
- Inflammatory Bowel Disease
- Hypothalamic control of reproductive hormones
- Wnt/β-catenin signaling in development and cancer
- Graphene and Nanomaterials Applications
Italian Institute of Technology
2023-2025
University of Pavia
2020-2024
Istituto Universitario di Studi Superiori di Pavia
2020-2024
University of Bologna
2024
The interaction between RAD51 and BRCA2 plays a key role in homologous recombination (HR), critical DNA repair mechanism essential for the survival of cancer cells. Disrupting this increases sensitivity cells to chemotherapeutic agents. Here, we employed silico methods design novel class aptamers-customized single-stranded oligonucleotides-specifically engineered bind RAD51. These aptamers were developed with aim selectively modulating RAD51's nuclear recruitment its processes. leading...
Abstract The RAD51-BRCA2 interaction is central to DNA repair through homologous recombination. Emerging evidence indicates RAD51 overexpression and its correlation with chemoresistance in various cancers, suggesting inhibition as a compelling avenue for intervention. We previously showed that combining olaparib (a PARP inhibitor (PARPi)) RS -35d BRCA2-RAD51 inhibitor) was efficient killing pancreatic ductal adenocarcinoma (PDAC) cells. However, impaired cell viability even when administered...
Receptor for activated C kinase 1 (RACK1) has an important role in immune activation, and is regulated through a balance between glucocorticoid androgen levels. We have previously demonstrated that RACK1 expression can serve as marker evaluation of immunotoxic profiles hormone-active substances, such endocrine-disrupting chemicals (EDCs). In this study, we investigated the effects three bisphenols (BPA, BPAF, BPS) on innate responses THP-1 human promyelocytic cell line, validated model...
Amyloid Precursor Protein (APP) and its cleavage processes have been widely investigated in the past, particular context of Alzheimer's Disease (AD). Evidence an increased expression APP amyloidogenic-related enzymes, β-secretase 1 (BACE1) γ-secretase, at hit axon terminals following Traumatic Brain Injury (TBI), firstly suggested a correlation between TBI AD. Indeed, mild severe recognised as influential risk factors for different neurodegenerative diseases, including In present work, we...
Several intracellular pathways that contribute to the adaptation or maladaptation environmental challenges mediate vulnerability and resilience chronic stress. The activity of hypothalamic-pituitary-adrenal (HPA) axis is fundamental for proper maintenance brain processes, it related functionality isoform alfa beta glucocorticoid receptor (Gr), primary regulator HPA axis. Among downstream effectors axis, scaffolding protein RACK1 covers an important role in regulating synaptic mediates...
Given the role of Receptor for Activated C Kinase 1 (RACK1) in both immune cell activation and maintenance intestinal epithelial barrier integrity, we investigated whether it was involved inflammatory bowel disease (IBD).
Abstract The innovative framework of a fully small molecule-induced synthetic lethality gained increasing attention for its promising application in the selective eradication cancer cells. Disrupting interaction between BRCA2 and RAD51, key players DNA repair by homologous recombination (HR), represents an interesting option within paradigm. We previously showed that combining PARP inhibitor (PARPi) olaparib with BRCA2-RAD51 disruptor RS-35d , racemic dihydroquinolone pyrazoline-derivative...