A5044052874- Astro and Planetary Science
- Economic Growth and Productivity
- Force Microscopy Techniques and Applications
- Isotope Analysis in Ecology
- Regional Development and Policy
- Nuclear Physics and Applications
- Economic Policies and Impacts
- Fiscal Policy and Economic Growth
- Gamma-ray bursts and supernovae
- Regional Economics and Spatial Analysis
- Economic Growth and Development
- Innovation Policy and R&D
- Cellular Mechanics and Interactions
- Labor market dynamics and wage inequality
- Advanced Thermodynamics and Statistical Mechanics
- Particle Detector Development and Performance
- Advanced Electron Microscopy Techniques and Applications
- Astrophysical Phenomena and Observations
- Composite Material Mechanics
- Astronomical Observations and Instrumentation
- Employment and Welfare Studies
- Mechanical and Optical Resonators
- Firm Innovation and Growth
- Material Dynamics and Properties
- Pulsars and Gravitational Waves Research
Centre National de la Recherche Scientifique
2012-2023
Aix-Marseille Université
2020-2023
Laboratoire Adhésion et inflammation
2020-2023
Inserm
2020-2023
Centre Interdisciplinaire de Nanoscience de Marseille
2020-2022
Organisation de Coopération et de Développement Economiques
2019
Laboratoire de Physique de l'ENS
2019
Laboratoire de Géologie de l’École Normale Supérieure
2019
Sorbonne Université
2019
Université Paris Cité
2019
Stretching experiments on single molecules of arbitrary length opened the way for studying statistical mechanics small systems. In many cases in which thermodynamic limit is not satisfied, different macroscopic boundary conditions, corresponding to ensembles, yield force-displacement curves. We formulate analytical expressions and develop Monte Carlo simulations quantitatively evaluate difference between Helmholtz Gibbs ensembles a wide range polymer models biological relevance. consider...
Significance We propose a mechanistic description of fusion synaptic vesicle with target membrane executed by team zippering SNARE complexes (SNAREpins). In the context neurotransmitters release, this process naturally decomposes in two steps rates that depend on number SNAREpins <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mi>N</mml:mi> </mml:math> . The first step is synchronized escape from metastable half-zippered state, which gets exponentially more...
We present a statistical mechanics analysis of the finite-size elasticity model polymers, consisting domains that can exhibit transitions between more than one stable state at large applied force. The constant-force (Gibbs) and constant-displacement (Helmholtz) formulations single-molecule stretching experiments are shown to converge in thermodynamic limit. Monte Carlo simulations continuous three-dimensional polymers variable length carried out, based on this formulation. demonstrate...
Recent developments of microscopic mechanical experiments allow the manipulation individual polymer molecules in two main ways: uniform stretching by external forces and non-uniform fields. Many results can be thereby obtained for specific kinds polymers geometries. In this work, we describe a single, non-branched molecule an field (e.g., fluid motion, or electric field) universal physical framework, which leads to general conclusions on different types polymers. We derive analytical both...
ABSTRACT Two meteorite pieces have been recovered in Italy, near the town of Cavezzo (Modena), on 2020 January 4th. The associated fireball was observed evening New Year’s Day by eight all-sky cameras PRISMA network, a partner FRIPON. computed trajectory had an inclination angle approximately 68° and velocity at infinity 12.8 km s−1. Together with relatively low terminal height, estimated as 21.5 km, those values were indicating significant possibility dropping event, additionally confirmed...
The effective transport properties of heterogeneous nanoscale materials and structures are affected by several geometrical physical factors. Among them the presence imperfect interfaces plays a central role being often at origin scale effects. To describe real contacts between different phases some classical schemes have been introduced in literature, namely low high conducting interface models. Here, we introduce generalized formalism, which is able to take into account both previous and,...
Manca F. Human capital composition and economic growth at the regional level, Regional Studies. This paper analyses impact of human on catch-up for Spain over period 1960–1997. Empirical evidence shows that has a non-linear convergence both NUTS-2 NUTS-3 geographical disaggregation levels. Tertiary education drives catch-up, while accumulation non-technical slows down this convergence. When one controls development stage regions, strong complementarities seem to arise between different types...
Based on the Community Innovation Survey, this paper suggests new indicators of innovation adoption. The magnitude adoption is assessed for 22 EU countries and different industries. most striking feature correlation between activities rate. Countries with strong R&D human resources high output exhibit highest rates. This supports idea that requires an absorption capability. In addition, specificities each country regarding prevailing types (product or process, cooperation-based internal...
Abstract The killing of tumor cells by ionizing radiation beams in cancer radiotherapy is currently based on a rather empirical understanding the basic mechanisms and effectiveness DNA damage radiation. By contrast, mechanical behaviour encompassing sequence sensitivity elastic transitions to plastic responses much better understood. A novel approach proposed here micromechanical Silicon Nanotweezers device. This instrument allows detailed biomechanical characterization bundle exposed an...
Bundles of fibers, wires, or filaments are ubiquitous structures in both natural and artificial materials. We investigate the bundle degradation induced by an external damaging action through a theoretical model describing assembly parallel progressively damaged random population cracks. Fibers our interact means lateral linear coupling, thus retaining structural integrity even after substantial damage. Monte Carlo simulations Young's modulus for increasing crack density demonstrate...
The statistical mechanics of arbitrary holonomic scleronomous systems subjected to external forces is described by specializing the Lagrange and Hamilton equations motion those Brownian on a manifold. In this context, Klein‐Kramers Smoluchowski are derived in covariant form, it demonstrated that these have equilibrium solutions corresponding Gibbs distribution, agreement with standard thermodynamics. At last, Langevin dynamics limit found exactly correspond smooth These results find...
Background Information Leukocytes migrate in an amoeboid fashion while patrolling our organism the search for infection or tissue damage. Their capacity to has been proven integrin independent, however, non‐specific adhesion confinement remain a requisite current models of cell migration. This idea challenged twice within last decade with human neutrophils and effector T lymphocytes, which were shown free suspension, phenomenon termed swimming. While relevance leukocyte swimming vivo remains...
Abstract History tells that institutions evolve gradually over time, pushing new ideas across borders and cultures. Globalization is argued to accelerate this process. We examine the spatial links of different political borders. Applying various tests for proximity, we do not find evidence contemporaneous links. This result robust measures distance cultural proximity countries. Instead, when analyse long-run dynamics, diffusion seems occur only gradually. Acknowledgements Peter Claeys...
Single-molecule force spectroscopy techniques allow for the measurement of several static and dynamic features macromolecules biological origin. In particular, atomic microscopy, used with a variable pulling rate, provides valuable information on folding/unfolding dynamics proteins. We propose here two different models able to describe out-of-equilibrium statistical mechanics chain composed bistable units. These latter represent protein domains, which can be either folded or unfolded. Both...
The statistical mechanics and the thermodynamics of small systems are characterized by non-equivalence ensembles. When concerning a polymer chain or an arbitrary independent units, this concept leads to different force-extension responses for isotensional (Gibbs) isometric (Helmholtz) thermodynamic ensembles limited number units (far from limit). While average response has been largely investigated in both Gibbs Helmholtz ensembles, full characterization thermo-mechanical behavior not...
The role of force application in immune cell recognition is now well established, the being transmitted between actin cytoskeleton to anchoring ligands through receptors such as integrins. In this chain, mechanics receptor link, though clearly crucial, remains poorly understood. To probe we combine mechanical extraction membrane tubes from T cells using optical tweezers, and fitting resulting curves with a viscoelastic model taking into account relevant molecules. We solicit link four...