A5025733264- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Iron oxide chemistry and applications
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Geomagnetism and Paleomagnetism Studies
- Advanced Photocatalysis Techniques
- Nanoplatforms for cancer theranostics
- Cellular Mechanics and Interactions
- Biosensors and Analytical Detection
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
- Magnetic Properties and Synthesis of Ferrites
- Catalysis and Oxidation Reactions
- Advancements in Battery Materials
- Anodic Oxide Films and Nanostructures
- Ferroelectric and Negative Capacitance Devices
- Bacteriophages and microbial interactions
- Extracellular vesicles in disease
- ZnO doping and properties
- Minerals Flotation and Separation Techniques
- Advanced Nanomaterials in Catalysis
- Catalytic Processes in Materials Science
- Microfluidic and Bio-sensing Technologies
University of Michigan
2022-2024
Korea University
2014-2023
BioSurfaces (United States)
2022-2023
Seoul Institute
2017-2019
Government of the Republic of Korea
2017-2019
Circulating tumor DNA (ctDNA) detection has been acknowledged as a promising liquid biopsy approach for cancer diagnosis, with various ctDNA assays used early and treatment monitoring. Dispersible magnetic nanoparticle-based electrochemical methods have proposed candidates based on the performance features of platform material. This study proposes nanoparticle surface-localized genetic amplification by integrating Fe3O4–Au core–shell nanoparticles into polymerase chain reactions (PCR). These...
Abstract Developing materials with the capability of changing their innate features can help to unravel direct interactions between cells and ligand‐displaying features. This study demonstrates grafting magnetic nanohelices displaying cell‐adhesive Arg‐Gly‐Asp (RGD) ligand partly a material surface. These enable nanoscale control rapid winding (“W”) unwinding (“UW”) nongrafted portion, such as directional changes in nanohelix (lower, middle, upper directions) by position permanent magnet...
Cell adhesion occurs when integrin recognizes and binds to Arg-Gly-Asp (RGD) ligands present in fibronectin. In this work, submolecular ligand size spacing are tuned via template-mediated situ growth of nanoparticles for dynamic macrophage modulation. To tune liganded gold nanoparticle (GNP) from 3 20 nm, localized assemblies GNP arrays on nanomagnetite templates engineered. nm-spaced stimulate the binding integrin, which mediates macrophage-adhesion-assisted pro-regenerative polarization as...
Of various molecular diagnostic assays, the real-time reverse transcription polymerase chain reaction is considered gold standard for infection diagnosis, despite critical drawbacks that limit rapid detection and accessibility. To confront these issues, several nanoparticle-based methods have been developed to a great extent, but still possess challenges. In this study, novel nucleic acid amplification method termed surface localized (nSLAM) paired with electrochemical (ECD) develop...
Zinc oxide (ZnO)-based nanocomposites have shown promising potential for various biomedical applications, including vaccine development, owing to their multifunctionality and biocompatibility. Here, we synthesized radially grown ZnO nanowires (NWs) on poly-l-lactic acid (PLLA) microfibers with unique 3-dimensional structure applied them as therapeutic cancer vaccines. This inorganic-organic hybrid nanocomposite has mild cellular toxicity but efficiently delivers a tumor antigen into...
The development of heat-generating magnetic nanostructures is critical for the effective management tumors using hyperthermia. Herein, we demonstrate that polyethylene glycol (PEG)-coated iron oxide (magnetite, Fe3O4) multigranule nanoclusters (PEG-MGNCs) can enhance efficiency hyperthermia-based tumor suppression in vitro and vivo. MGNCs consisting granules (crystallites) measuring 22.9 nm diameter were prepared via hydrothermal polyol method, followed by surface modification with...
Abstract Mesocrystals are assemblies of smaller crystallites and have attracted attention because their nonclassical crystallization pathway emerging collective functionalities. Understanding the mesocrystal mechanism in chemical routes is essential for precise control size microstructure, which influence function mesocrystals. However, microstructure evolution from nucleus stage through various pathways remains unclear. We propose a unified model on basis observation two pathways, with...
In the crystallisation of nanomaterials, an assembly-based mechanism termed 'oriented attachment' (OA) has recently been recognised as alternative crystal growth that cannot be explained by classical theory. However, attachment alignment during OA is not currently tuneable because its poorly understood. Here, we identify crystallographic disorder-order transitions in magnetite (Fe3O4) mesocrystals depending on types organic surface ligands building blocks, which produce different grain...
MnOx-based catalysts have been applied to the selective catalytic reduction of NOx with ammonia (NH3) owing their high removal efficiency and stability. In general, fabrication a variety nanomaterials in complex structure requires complicated processes, including heat treatment series cleaning steps. addition, MnO2 which has diverse polymorphs, exhibits different effects depending on its crystalline structure. Among them, synthesizing ε-MnO2 phase, functions as nanocatalyst, most difficult...
Abstract Magnetic‐plasmonic nanoparticles have received considerable attention for widespread applications. These (NPs) exhibiting surface‐enhanced Raman scattering (SERS) activities are developed due to their potential in bio‐sensing applicable non‐destructive and sensitive analysis with target‐specific separation. However, it is challenging synthesize these NPs that simultaneously exhibit low remanence, maximized magnetic content, plasmonic coverage abundant hotspots, structural...
Barcode nanowires (BNWs) composed of multiple layered segments different materials are attractive to bioengineering field due their characteristics that allow the adjustment physicochemical properties and conjugation with two or more types biomolecules facilitate tasks. Here, we report a metallic Fe (iron)–Au (gold) BNW-based platform for capturing CD8 T cells interferon-γ (γ) they secrete, both which play key roles in controlling infectious diseases such as tuberculosis, at single-cell...
Abstract The artificial construction of nature‐mimic inorganic–organic heterostructures is an emerging technological interest for protective surface applications. Mimicking the spikiness sea urchin spicules their function, here, synthesis zinc oxide (ZnO) nanometer‐scale grown from micrometer‐scale polylactic acid (PLA) beads and fibers as super‐hydrophilic bactericidal surfaces reported. thermodynamic mechanism behind interfacial assembly pre‐entrapped ZnO nanoparticles right at PLA–water...
Cell Adhesion In article number 2110340, Ramasamy Paulmurugan, Young Keun Kim, Heemin Kang, and co-workers report template-mediated in situ tuning of nanoligand size spacing. They demonstrate that submolecular ligand spacing magnetic anchoring facilitate adhesion-structure assembly-mediated pro-healing polarization host macrophages. Increasing the significantly suppresses macrophage adhesion whereas increasing both slightly inhibits it.
Rotavirus is a leading cause of death in young children worldwide. Although vaccines are currently available and reduce the disease burden, most low-income countries rely on diagnosis by point-of-care testing owing to its rapidity, simplicity, affordability; however, sensitivity remains problem. Magnetically assisted antigen enrichment improves with increased fluorescence intensity. However, magnetic nanoparticles (NPs) strongly absorb ultraviolet light, limiting combination NPs quantum dots...
Fan-shaped ZnO nanowire arrays can mediate intracellular delivery of non-covalently associated peptides and DNA.
Abstract Tertiary lymphoid structures (TLSs) provide specialized niches for immune cells, resulting in improved prognoses patients undergoing cancer immunotherapy. Shaping TLS‐like may improve anti‐cancer immunity and overcome the current limitations of cell‐based Here, it is shown that stromal vascular fraction (SVF) from adipose tissues can enhance dendritic cell (DC)‐mediated T by inducing ectopic lymphocyte clusters. SVF cells expanded ex vivo have phenotypes functions similar to those...
Arsenic (As)-contaminated soil inevitably exists in nature and has become a global challenge for sustainable future. Current processes As capture using natural structurally engineered nanomaterials are neither scientifically nor economically viable. Here, we established feasible strategy to enhance As-capture efficiency ecosystem health by reorganizing iron oxyhydroxide, stabilizer. We propose crystallization reorganize FeOOH-acetate nanoplatelets (r-FAN), which is universal either scalable...
Abstract Mesocrystals, consisting of small subunits, have gained research interests owing to their ability simultaneously modify material‐specific properties and interactions among subunits. However, despite these unique characteristics, most mesocrystals are composed a single material, there is disjunction between academic discovery practical application. In this study, the synthesis multi‐component mesocrystalline nanoparticles Fe 3 O 4 , ZnFe 2 ZnO subunits using polymerization induced...
Magnetite nanoparticles combined with polymers produce white-light emission under multiphoton laser irradiation.