A5101892013- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Nanoparticles: synthesis and applications
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Effects of Radiation Exposure
- Pesticide Exposure and Toxicity
- Free Radicals and Antioxidants
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Electrochemical Analysis and Applications
- Mitochondrial Function and Pathology
- Nanocluster Synthesis and Applications
- Cholinesterase and Neurodegenerative Diseases
- Plant chemical constituents analysis
- Metabolism and Genetic Disorders
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Carbon Nanotubes in Composites
- Metal complexes synthesis and properties
- Radiation Therapy and Dosimetry
- RNA Interference and Gene Delivery
- BRCA gene mutations in cancer
- Acute Lymphoblastic Leukemia research
University of Belgrade
2016-2025
Vinča Institute of Nuclear Sciences
2004-2021
Institute of Economic Sciences
2004-2021
Vienna Institute for Nature Conservation & Analyses
2013
Ben-Gurion University of the Negev
2008
Institute of Pharmacology
2007
Chemical Dynamics (United States)
2004-2005
University of Alberta
2002
Carbon nanotubes are unique one-dimensional macromolecules with promising applications in biology and medicine. Since their toxicity is still under debate, here we present a study investigating the genotoxic properties of purified single wall carbon (SWCNTs), multiwall (MWCNTs), amide functionalized SWCNTs on cultured human lymphocytes employing cytokinesis block micronucleus assay enumeration γH2AX foci as measure double strand breaks (DSBs) DNA normal fibroblasts. induce micronuclei (MN)...
Metals are integral components of the natural environment, and their presence in food supply is inevitable complex. While essential metals such as sodium, potassium, magnesium, calcium, iron, zinc, copper crucial for various physiological functions must be consumed through diet, others, like lead, mercury, cadmium, toxic even at low concentrations pose serious health risks. This study comprehensively analyzes presence, importance, consequences chain. We explore pathways which enter supply,...
Pesticides are very important in modern agriculture, protecting crops against pests and diseases to ensure food safety. However, the use of pesticides production has raised significant concerns regarding their potential impacts on human health environment. This review provides comprehensive insights into current status, future projections, debates surrounding food. Beginning with a historical overview pesticide types commonly used presence residues commodities explored. The environmental...
Fanconi anemia (FA) is characterized by sensitivity to DNA cross-linking agents, mild cellular, and marked clinical radio sensitivity. In this study we investigated telomeric abnormalities of non-immortalized primary cells (lymphocytes fibroblasts) derived from FA patients the FA-D2 complementation group, which provides a more accurate physiological assessment than possible with transformed or animal models.We analyzed telomere length, dysfunction-induced foci (TIFs), sister chromatid...
Fanconi anaemia (FA) is a genetic cancer predisposition disorder associated with cytogenetic instability, bone marrow failure and pleiotropic cellular phenotype, including low thresholds of responses to oxidative stress, cross-linking agents selected cytokines. This study was aimed at defining the scope abnormalities in gene expression using publicly available FA Transcriptome Consortium (FTC) database (Gene Expression Omnibus, 2009 as GSE16334). We evaluated data set that included...
Among patients with bone marrow failure (BMF) syndrome, some are happened to have underlying Fanconi anemia (FA), a genetically heterogeneous disease, which is characterized by progressive pancytopenia and cancer susceptibility. Due nature of the single genetic test, as in vitro response DNA cross-linking agents, usually not enough make correct diagnosis. The aim this study was evaluate whether measuring repair kinetics radiation-induced double-strand breaks (DSBs) can distinguish from other...
The aim of this study was to evaluate whether or not low radiation doses can induce an adaptive response in human lymphocytes exposed vivo. We examined chromosome aberrations, micronuclei, radiosensitivity, and apoptosis the peripheral blood young workers (mean age 35.8 ± 9) with 14.9 5.2 years occupational exposure ionizing radiation. Adaptive estimated using two parameters radiosensitivity: micronuclei apoptosis. Baseline radiation-induced (2 Gy, 60Co γ-rays) were assessed cytochalasin...
Biological Effects of Echinacea Purpurea on Human Blood Cells The aim this study was to investigate radioprotective properties purpurea tablets in vivo . We analysed lymphocyte chromosome aberrations (CA), micronuclei (MN), apoptosis leukocytes and haematological parameters a group radiation workers who were identified as carrying dicentric chromosomes their lymphocytes. All taking two 275 mg b.i.d. , according pharmacist's recommendation. before after the two-week treatment. At end...
The aim of this study was to identify active principles Gentianella austriaca responsible for the reduction incidence micronuclei in irradiated lymphocytes vitro. radioprotective effects ether (EF) and methanolic (MeF) fractions, water-soluble xanthones demethylbellidifolin (1), 8-O-glucoside (2), bellidifolin (3), flavonoid swertisin (4) against chromosomal damage induced by γ-rays were determined using micronucleus test. EF MeF showed better protection treatment human after γ-irradiation...
The aim of the present study was to establish extent in vitro radioresponse lymphocytes among 62 healthy adults both genders and estimate distribution baseline micronuclei radiosensitivity individuals population using cytochalasin block micronucleus test. A younger group consisted 10 males (mean age, 22.4 years; range, 21-27) 12 females 24.8 20-29), whereas an older 18 35.1 30-44) 22 38.5 30-48). For evaluation blood samples were irradiated 60Co g-ray source. radiation dose employed 2 Gy,...
Abstract Fanconi anemia (FA) is a rare cancer-prone genetic disorder characterized by progressive bone marrow failure, chromosomal instability and redox abnormalities. There much biochemical data, which strongly suggest that FA cells experience increased oxidative stress. The present study was designed to elucidate if differences in oxidant state exist between control, idiopathic failure (idBMF) cells, analyze of heterozygous carriers as well. results the confirm an vivo prooxidant clearly...