A5005954648- Sepsis Diagnosis and Treatment
- Urinary Tract Infections Management
- Antibiotic Resistance in Bacteria
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Emergency and Acute Care Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Clinical Reasoning and Diagnostic Skills
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Statistical Methods in Clinical Trials
- Advanced Causal Inference Techniques
- Escherichia coli research studies
- Liver Disease and Transplantation
- Prostate Cancer Diagnosis and Treatment
- Surgical site infection prevention
- Hemodynamic Monitoring and Therapy
- Abdominal vascular conditions and treatments
- Liver Diseases and Immunity
- Family and Patient Care in Intensive Care Units
- Genital Health and Disease
Lund University
2017-2025
Helsingborgs lasarett
2019-2025
Early administration of antibiotics is associated with better survival in sepsis, thus screening and early detection for sepsis clinical importance. Current risk stratification scores used bedside example Quick Sequential Organ Failure Assessment (qSOFA) National Warning Score 2 (NEWS2), are primarily validated death intensive care. The primary aim this study was to compare the diagnostic accuracy qSOFA NEWS2 a composite outcome organ dysfunction, infection-related mortality within <72 h,...
ABSTRACT Objective: Rapid and early detection of patients at risk to develop sepsis remains demanding. Heparin-binding protein (HBP) has previously demonstrated good prognostic properties in detecting organ dysfunction among with suspected infections. This study aimed evaluate the plasma levels HBP as a biomarker for infection-induced seeking medical attention emergency department. Design: Prospective, international multicenter, convenience sample study. Setting: Four general departments...
Sepsis-related acute kidney injury (AKI) accounts for major morbidity and mortality among the critically ill. Heparin-binding protein (HBP) is a promising biomarker in predicting development prognosis of severe sepsis septic shock that has recently been proposed to be involved pathophysiology AKI. The objective this study was investigate added predictive value measuring plasma HBP on admission intensive care unit (ICU) regarding We included 601 patients with or from prospective,...
Abstract Background Heparin-binding protein (HBP) is a neutrophil-derived pro-inflammatory protein, an inducer of endothelial dysfunction and vascular permeability promising prognostic biomarker in sepsis. This exploratory study aims to describe the kinetics plasma HBP during septic shock investigate association between repeated measures concentration cardiovascular organ severity. Methods We included patients at or above 18 years with suspected on admission intensive care unit (ICU) 2014...
To allow early identification of patients at risk sepsis in the emergency department (ED), a variety stratification scores and/or triage systems are used. The first aim this study was to develop score for based upon vital signs and biomarkers using statistical approach. Second, we aimed validate Rapid Emergency Triage Treatment System (RETTS) sepsis. RETTS combines with symptoms stratification.We retrospectively analysed data from two prospective, observational, multicentre cohorts studies...
Background: There are no clinical or laboratory markers that can diagnose acute mesenteric ischemia (AMI) accurately. This study aimed to find differences in and between arterial occlusive AMI other abdominal diseases where was initially suspected. Methods: a post hoc of an international prospective multicenter data on patients with suspected were collected. Independent factors associated evaluated multivariable logistic regression analysis. Results: The number 231, consisting thrombotic (n...
Abstract Background Patients with COVID-19 and hypoxaemia despite conventional low-flow oxygen therapy are often treated high-flow nasal cannula (HFNC) in line international guidelines. Oxygen delivery by helmet continuous positive airway pressure (CPAP) is a feasible option that enables higher end-expiratory (PEEP) may theoretically reduce the need for intubation compared to HFNC but direct comparative evidence lacking. Methods We plan perform an investigator-initiated, pragmatic,...
Transient elastography (TE) has largely replaced liver biopsy to evaluate fibrosis stage and cirrhosis in chronic hepatitis C. Previous studies have reported excellent reliability of TE but agreement metrics not been reported. This study aimed assess interrater repeated measurements.
Background Transrectal prostate biopsy (TRbx) transfers colonic bacteria into prostatic tissue, potentially causing infectious complications, including sepsis. Our objective was to determine whether needle shape, surface properties and sampling mechanism affect the number of transferred through colon wall, evaluate a novel with improved properties.Methods The standard Tru-Cut used today evaluated for mechanisms bacterial transfer in pilot study. A (Forsvall prototype) developed. TRbx...
Abstract Background Oral treatment alternatives for febrile urinary tract infections are limited in the era of increasing antimicrobial resistance. We aim to evaluate if combination pivmecillinam and amoxicillin/clavulanic acid is non-inferior current step-down therapy adult patients with infection. Methods plan perform an investigator-initiated non-inferiority trial. Adult hospitalised treated 1–5 days intravenous antibiotics acute infection caused by extended spectrum beta-lactamase (ESBL)...
Abstract · Background : Oral treatment alternatives for febrile urinary tract infections are limited in the era of increasing antimicrobial resistance. We aim to evaluate if combination pivmecillinam and amoxicillin/clavulanic acid is non-inferior current step-down therapy adult patients with infection. Methods plan perform an investigator-initiated non-inferiority trial. Adult hospitalised treated 1-5 days intravenous antibiotics acute infection caused by extended spectrum beta-lactamase...
Abstract Background : Patients with COVID-19 and hypoxemia despite conventional low-flow oxygen therapy are often treated High-flow Nasal Cannula (HFNC) in line international guidelines. Oxygen delivery by Helmet Continuous Positive Airway Pressure (CPAP) is a feasible option that enables higher positive end-expiratory pressure (PEEP) may theoretically reduce the need for intubation compared to HFNC but direct comparative evidence lacking. Methods We plan perform an investigator-initiated,...
Abstract Background : Patients with COVID-19 and hypoxemia despite conventional low-flow oxygen therapy are often treated High-flow Nasal Cannula (HFNC) in line international guidelines. Oxygen delivery by Helmet Continuous Positive Airway Pressure (CPAP) is a feasible option that enables higher positive end-expiratory pressure (PEEP) may theoretically reduce the need for intubation compared to HFNC but direct comparative evidence lacking. Methods We plan perform an investigator-initiated,...
Abstract Background Transient elastography (TE) has largely replaced liver biopsy to evaluate fibrosis stage and cirrhosis in chronic hepatitis C. Previous studies report excellent reliability of TE but agreement metrics have not been reported. This study aimed assess inter-rater repeated measurements. Methods Two operators performed independently, directly after each other. The primary outcome was disagreement, defined as a difference results between ≥ 33%, well the smallest detectable...
Background: The aim of this study was to provide a descriptive account carbapenem resistance and risk factors for mortality from invasive Acinetobacter infections in the south Sweden.Methods: Blood isolates with growth species between 2010 2019 Skåne county were subtyped using MALDI-TOF subjected susceptibility testing against clinically relevant antibiotics. Association 30-day analysed univariate multivariate logistic regression models.Results: There 179 bacteraemia episodes 176 patients...