A5080093408- Helminth infection and control
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Nematode management and characterization studies
- Insect symbiosis and bacterial influences
- Vector-borne infectious diseases
- Genetic and phenotypic traits in livestock
- Malaria Research and Control
- Parasitic Infections and Diagnostics
- Coccidia and coccidiosis research
- Mosquito-borne diseases and control
- Toxoplasma gondii Research Studies
- Genomics and Phylogenetic Studies
- Trypanosoma species research and implications
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Insect and Pesticide Research
- Aquaculture disease management and microbiota
- Parasitic Diseases Research and Treatment
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- Microbial infections and disease research
- Genetic diversity and population structure
- Ruminant Nutrition and Digestive Physiology
- Virology and Viral Diseases
University of Edinburgh
2016-2025
Long Island University
2024-2025
University of Surrey
2020-2024
St. George's University
2023-2024
Roslin Institute
2016-2024
Quaid-i-Azam University
2022
University of Veterinary and Animal Sciences
2014-2021
University of Calgary
2014-2020
Scotland's Rural College
2019
University of Delhi
2013
Abstract Despite only 8% of cattle being found in Europe, European breeds dominate current genetic resources. This adversely impacts research other important global breeds, especially those from Africa for which genomic resources are particularly limited, despite their disproportionate importance to the continent’s economies. To mitigate this issue, we have generated assemblies African been integrated with data 294 diverse into a graph genome that incorporates diversity. We illustrate how...
Abstract Haemonchus contortus is a globally distributed and economically important gastrointestinal pathogen of small ruminants has become key nematode model for studying anthelmintic resistance other parasite-specific traits among wider group parasites including major human pathogens. Here, we report using PacBio long-read OpGen 10X Genomics long-molecule methods to generate highly contiguous 283.4 Mbp chromosome-scale genome assembly resolved sex chromosome the MHco3(ISE).N1 isolate. We...
Like other pathogens, parasitic helminths can rapidly evolve resistance to drug treatment. Understanding the genetic basis of anthelmintic in nematodes is key tracking its spread and improving efficacy sustainability parasite control. Here, we use an vivo cross between drug-susceptible multi-drug-resistant strains Haemonchus contortus a natural host-parasite system simultaneously map loci for three major classes anthelmintics. This approach identifies new alleles benzimidazoles levamisole...
Abstract Background Ivermectin is an endectocide against many parasites. Though being a macrocyclic lactone, its activity bacteria has been less known, possibly due to the fact that micromolar concentrations at tissue levels are required achieve therapeutic effect. Among pathogenic of major medical significance, Staphylococcus aureus cause number diseases in wide variety hosts including humans and animals. It attributed as one most organisms. The emergence methicillin resistance made...
The antiparasitic drug ivermectin plays an essential role in human and animal health globally. However, resistance is widespread veterinary helminths there are growing concerns of sub-optimal responses to treatment related humans. Despite decades research, the genetic mechanisms underlying poorly understood parasitic helminths. This reflects significant uncertainty regarding mode action helminths, complexity these organisms; have large, rapidly evolving genomes differences evolutionary...
The parasitic nematode Haemonchus contortus is an economically and clinically important pathogen of small ruminants, a model system for understanding the mechanisms evolution traits such as anthelmintic resistance. Anthelmintic resistance widespread major threat to sustainability livestock agriculture globally; however, little known about genome architecture parameters recombination that will ultimately influence rate at which may evolve spread. Here, we performed genetic cross between two...
Abstract Background The giant roundworm Ascaris is an intestinal nematode, causing ascariasis by infecting humans and pigs worldwide. Recent estimates suggest that infects over half a billion people, with chronic infections leading to reduced growth cognitive ability. Ascariasis affects innumerable worldwide known reduce production yields via decreased condemnation of livers. predominant anthelminthic drugs used treat are the benzimidazoles. Benzimidazoles interact β-tubulins block their...
Trypanosomes are parasitic protozoa that cause severe diseases in humans and animals. The most important species of Trypanosmes include Trypanosoma evansi brucei gambiense. well-known human sleeping sickness Africa Chagas disease South America. identified animal Nagana the African tsetse fly belt Surra Asia, North Africa, Middle East. is caused by evansi. Diminazene resistance an emerging threat T. infecting underlying mechanism diminazene poorly understood. gambiense causes sickness....
Anthelmintic resistant gastrointestinal helminths have become a major cause of poor health in sheep and goats. Sensitive specific molecular markers are needed to monitor the genotypic frequency resistance field parasite populations. Gastrointestinal nematode benzimidazole is caused by mutation one three positions within isotype 1 β-tubulin gene. In absence for other broad spectrum anthelmintic classes, these provide relevant study example. Determination prevalence single nucleotide...
Abstract Gastrointestinal nematodes (GINs) are a common threat faced by pastoral livestock. Since their major introduction to the UK in early 1990s, South American camelids have been cograzed with sheep, horses, and other livestock, allowing exposure range of GIN species. However, there no molecular-based studies investigate populations present these camelids. In current study, we sampled nine alpaca herds from northern England southern Scotland used high-throughput metabarcoded sequencing...
The impact of drug selection pressure on the overall genetic diversity parasitic nematode populations in field is poorly understood. In this study, we address issue for small ruminant parasite Haemonchus contortus Punjab, Pakistan. This region provides an opportunity to compare H. that have been subjected a prolonged period frequent benzimidazole treatments government farms with exposed little or no treatment neighbouring pastoral herds. Adult worms were collected from abomasa ruminants...