A5015577727- Parasites and Host Interactions
- Helminth infection and control
- Parasite Biology and Host Interactions
- Vector-borne infectious diseases
- Insect symbiosis and bacterial influences
- Neurotransmitter Receptor Influence on Behavior
- Vector-Borne Animal Diseases
- Salmonella and Campylobacter epidemiology
- Insect and Pesticide Research
- Nematode management and characterization studies
- Scientific Computing and Data Management
- Pharmaceutical and Antibiotic Environmental Impacts
- Business Process Modeling and Analysis
- Parkinson's Disease Mechanisms and Treatments
- Ion channel regulation and function
- Cannabis and Cannabinoid Research
- Viral Infections and Vectors
- Forensic Toxicology and Drug Analysis
- Antibiotic Resistance in Bacteria
- Mosquito-borne diseases and control
- Insect Resistance and Genetics
- Artificial Intelligence in Healthcare
- Big Data and Business Intelligence
Animal and Plant Health Agency
2024
University of Surrey
2020-2024
Kingston University
2007-2022
Liverpool School of Tropical Medicine
2021
Abstract Background The giant roundworm Ascaris is an intestinal nematode, causing ascariasis by infecting humans and pigs worldwide. Recent estimates suggest that infects over half a billion people, with chronic infections leading to reduced growth cognitive ability. Ascariasis affects innumerable worldwide known reduce production yields via decreased condemnation of livers. predominant anthelminthic drugs used treat are the benzimidazoles. Benzimidazoles interact β-tubulins block their...
The treatment coverage of control programs providing benzimidazole (BZ) drugs to eliminate the morbidity caused by soil-transmitted helminths (STHs) is unprecedently high. This high drug pressure may result in development BZ resistance STHs and so there an urgent need for surveillance systems detecting molecular markers associated with resistance. A critical prerequisite develop such understanding gene family encoding β-tubulin proteins, principal targets drugs.First, families Ascaris...
Abstract Schistosoma spindale and indicum are ruminant-infecting trematodes of the group that widespread across Southeast Asia. Though neglected, these parasites can cause major pathology mortality to livestock leading significant welfare socio-economic issues, predominantly amongst poor subsistence farmers their families. Here we used mitogenomic analysis determine relationships between two sympatric species schistosome characterise S. diversity in order identify possible cryptic...
The efficacy of benzimidazole anthelmintics can vary depending on the target parasite, with Ascaris nematodes being highly responsive, and whipworms less responsive. Anthelmintic resistance has become widespread, particularly in strongyle such as Haemonchus contortus ruminants, recently been detected hookworms humans dogs. Past work shown that there are multiple β-tubulin isotypes helminths, yet only a few these contribute to interactions resistance. ascarids soil-transmitted helminths were...
Control of tropical theileriosis, caused by the apicomplexan Theileria annulata, depends on use a single drug, buparvaquone, efficacy which is compromised emergence resistance. The present study was undertaken to improve understanding role mutations conferring buparvaquone resistance in T. and effects selection pressures their spread. First, we investigated genetic characteristics cytochrome b locus associated with 10 susceptible 7 resistant annulata isolates. 129G (GGC) mutation found Q01...
Abstract Ascaris species are soil-transmitted helminths that infect humans and livestock mainly in low middle-income countries. Benzimidazole (BZ) class drugs have predominated for many years the treatment of infections, but persistent use BZs has already led to widespread resistance other nematodes, failure is emerging . Benzimidazoles act by binding β-tubulin proteins destabilising microtubules. Three mutations protein family associated with BZ resistance. Seven shared isotypes were...
The Primary Care Data Quality programme (PCDQ) is a quality-improvement which processes routinely collected general practice computer data. Patient data from wide range of different brands clinical systems are aggregated, processed, and fed back to practices in an educational context improve the quality care. Process modelling well-established approach used gain understanding systematic appraisal, identify areas improvement business process. Unified language (UML) purpose technique for this...
Cannabis is one of the most commonly used recreational drugs worldwide. Rrecent epidemiology studies have linked increased cardiac complications to cannabis use. However, this literature predominantly based on case incidents and post-mortem investigations. This study elucidates molecular mechanism Δ9-tetrahydrocannabinol (THC), its primary metabolites 11-Hydroxy-Δ9-THC (THC-OH) 11-nor-9-carboxy-Δ⁹-tetrahydrocannabinol (THC-COOH). Treatment myocytes with THC-OH THC-COOH cell migration...
Cocaine is one of the most widely abused illicit drugs worldwide and has long been recognised as an agent cardiac dysfunction in numerous cases drug overdose. previously shown to up-regulate cytoskeletal rearrangements morphological changes tissues; however, previous literature observes such primarily clinical case reports addiction studies. An investigation into fundamental parameters migration, adhesion proliferation were studied determine cytotoxic basis cocaine cells. Treatment myocytes...
Ticks are the main arthropod vector of pathogens to humans and livestock in British Isles. Despite their role as a disease, many aspects tick biology, ecology, microbial association poorly understood. To address this, we investigated composition microbiome adult nymphal Ixodes ricinus ticks. The ticks were collected on dairy farm Southwest England RNA extracted for whole genome sequencing. Sequences detected from range microorganisms, particularly tick-associated viruses, bacteria,...
ABSTRACT Babesia divergens , a major cause of bovine babesiosis with zoonotic potential, was analyzed through genomes Bdiv23B and Bdiv24B following Illumina sequencing DNA extracted from PCR-positive cattle blood. The comprised 3888 4032 predicted coding sequences, respectively, comparable to the reference genome, Rouen 1987, highlighting genomic consistency across isolates.
Abstract Ascaris species are soil-transmitted helminths that infect humans and livestock mainly in low middle-income countries. Benzimidazole (BZ) class drugs have predominated for many years the treatment of infections, but persistent use BZs has already led to widespread resistance other nematodes, failure is emerging . Benzimidazoles act by binding β-tubulin proteins destabilising microtubules. Three mutations protein family associated with BZ resistance. Seven shared isotypes were...
Abstract Control of tropical theileriosis depends on the use a single drug, buparvaquone, efficacy which is compromised by emergence resistance. The present study was undertaken to improve understanding role mutations conferring buparvaquone resistance in Theileria annulata , and effects selection pressures their spread. First, we investigated genetic characteristics cytochrome b locus associated with 10 susceptible 7 resistant T. isolates. 129G (GGC) mutation found Q 01 binding pocket 253S...
Abstract Background Despite considerable recent reductions in antimicrobial use, the UK gamebird industry continues to struggle with production diseases during rearing season, necessitating significant antibiotic use. This observational study investigated presence of genes conferring resistance β‐lactam antibiotics within industry‐reared pheasants and red‐legged partridges UK. Methods DNA was extracted from 60 pooled caecal samples collected gamebirds at routine postmortem examinations...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Abstract Ascaris species are soil-transmitted helminths that infect humans and livestock mainly in low middle-income countries. Benzimidazole (BZ) class drugs have predominated for many years the treatment of infections, but persistent use BZs has already led to widespread resistance other nematodes, failure is emerging . Benzimidazoles act by binding β-tubulin proteins destabilising microtubules. Three mutations protein family associated with BZ resistance. Seven shared isotypes were...