A5044118809- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Airway Management and Intubation Techniques
- Mechanical Circulatory Support Devices
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- COVID-19 Impact on Reproduction
- Injury Epidemiology and Prevention
- Inhalation and Respiratory Drug Delivery
- Lipoproteins and Cardiovascular Health
- Vaccine Coverage and Hesitancy
- Thermal Regulation in Medicine
- Computational Drug Discovery Methods
- Immune cells in cancer
- Family and Patient Care in Intensive Care Units
- Pharmaceutical Economics and Policy
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Antibiotic Resistance in Bacteria
Agostino Gemelli University Polyclinic
2021-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2023
Università Cattolica del Sacro Cuore
2020-2023
University of The Sacred Heart
2021
University of the Sacred Heart
2021
University of Campania "Luigi Vanvitelli"
2019
<h3>Importance</h3> High-flow nasal oxygen is recommended as initial treatment for acute hypoxemic respiratory failure and widely applied in patients with COVID-19. <h3>Objective</h3> To assess whether helmet noninvasive ventilation can increase the days free of support COVID-19 compared high-flow alone. <h3>Design, Setting, Participants</h3> Multicenter randomized clinical trial 4 intensive care units (ICUs) Italy between October December 2020, end follow-up February 11, 2021, including 109...
Rationale: The respective effects of positive end-expiratory pressure (PEEP) and support delivered through the helmet interface in patients with hypoxemia need to be better understood. Objectives: To assess (noninvasive ventilation [NIV]) continuous airway (CPAP) compared high-flow nasal oxygen (HFNO) on effort breathe, lung inflation, gas exchange (PaO2/FiO2 ⩽ 200). Methods: Fifteen underwent 1-hour phases (constant FiO2) HFNO (60 L/min), NIV (PEEP = 14 cm H2O, 12 H2O), CPAP H2O) randomized...
<h3>BACKGROUND:</h3> The efficacy of noninvasive oxygenation strategies (NIOS) in treating COVID-19 disease is unknown. We conducted a prospective observational study to assess the rate NIOS failure subjects treated ICU for hypoxemic respiratory due COVID-19. <h3>METHODS:</h3> Patients receiving first-line treatment university hospital were included this study; laboratory data collected upon arrival, and 28-d outcome was recorded. After propensity score matching based on Simplified Acute...
The effects of awake prone position on the breathing pattern hypoxemic patients need to be better understood. We conducted a crossover trial assess physiological in with acute respiratory failure.Fifteen failure and PaO2/FiO2 < 200 mmHg underwent high-flow nasal oxygen for 1 h supine 2 position, followed by final 1-h phase. At end each study phase, following parameters were measured: arterial blood gases, inspiratory effort (ΔPES), transpulmonary driving pressure (ΔPL), rate esophageal...
Background Positive end-expiratory pressure (PEEP) benefits in acute respiratory distress syndrome are driven by lung dynamic strain reduction. This depends on the variable extent of alveolar recruitment. The recruitment-to-inflation ratio estimates recruitability across a 10–cm H2O PEEP range through simplified maneuver. Whether is uniform or not this unknown. hypotheses study that represents an accurate estimate PEEP-induced changes strain, but may show nonuniform behavior conventionally...
(1) Background: Colistin-only susceptible (COS) Acinetobacter baumannii (AB) ventilator-associated pneumonia (VAP) represents a clinical challenge in the Intensive Care Unit (ICU) due to negligible lung diffusion of this molecule and low-grade evidence on efficacy its nebulization. (2) Methods: We conducted prospective observational study 134 ICU patients with COS-AB VAP describe 'real life' use high-dose (5 MIU q8) aerosolized colistin, using vibrating mesh nebulizer. Lung pharmacokinetics...
In non-COVID-19 acute hypoxaemic respiratory failure, the entity of dyspnoea has been associated with severity hypoxaemia, and represents a factor predicting noninvasive ventilation (NIV) need for endotracheal intubation mortality [1]. #COVID19 patients, presence moderate-to-severe is marker disease correlated to clinical outcomes <https://bit.ly/3Bp2G1b> We are grateful all intensive care unit physicians, residents, nurses personnel from participating centres, whose sacrifice, efforts,...
Abstract Background There is growing interest towards the use of helmet noninvasive ventilation (NIV) for management acute hypoxemic respiratory failure. Gas conditioning through heat and moisture exchangers (HME) or heated humidifiers (HHs) needed during facemask NIV to provide a minimum level humidity in inspired gas (15 mg H 2 O/L). The optimal strategy remains be established. Methods Twenty patients with failure (PaO /FiO < 300 mmHg) underwent consecutive 1-h periods (PEEP 12 cmH O,...
Introduction Remdesivir and Dexamethasone represent the cornerstone of therapy for critically ill patients with acute hypoxemic respiratory failure caused by Coronavirus Disease 2019 (COVID-19). However, clinical efficacy safety concomitant administration (Rem-Dexa) in severe COVID-19 on high flow oxygen (HFOT) or non-invasive ventilation (NIV) remains unknown. Materials methods Prospective cohort study that was performed two medical Intensive Care Units (ICUs) a tertiary university...
Abstract Background Long-term outcomes of patients treated with helmet noninvasive ventilation (NIV) are unknown: safety concerns regarding the risk patient self-inflicted lung injury and delayed intubation exist when NIV is applied in hypoxemic patients. We assessed 6-month outcome who received or high-flow nasal oxygen for COVID-19 respiratory failure. Methods In this prespecified analysis a randomized trial versus (HENIVOT), clinical status, physical performance (6-min-walking-test 30-s...
We conducted a proof of concept study where Anapnoguard endotracheal tubes and its control unit were used in 15 patients with COVID-19 acute respiratory distress syndrome. system provides suction, venting, rinsing subglottic space controls cuff pressure detecting air leakage through the cuff. Alpha-amylase pepsin levels, as oropharyngeal gastric microaspiration markers, assessed from 85 tracheal aspirates first 72 h after connection to system. Oropharyngeal occurred 47 cases (55%). Episodes...
Introduction: T-wave amplitude variability (TAV) is a noninvasive index of beat-to-beat variations in ventricular repolarization.Aim the study was to evaluate whether this parameter might reflect changes repolarization process induced by myocardial reperfusion, setting acute ischemia.Methods and results: 97 patients with diagnosis non-ST-elevation infarction (NSTE-MI) eligible for coronary revascularization were studied.In each patient, 20 minute three pseudo-orthogonal lead recording...
COVID-19 vaccination has been proved to be effective in preventing hospitalization and illness progression, even though data on mortality of vaccinated patients the intensive care unit (ICU) are conflicting. The aim this study was investigate characteristics admitted ICU according their immunization cycle outline risk factors for 28-day mortality. This observational included adult acute respiratory failure (ARF) due SARS-CoV-2 who had received at least one dose vaccine.Fully defined as a...
Abstract Background: Although widely applied, noninvasive ventilatory support (NIVS) efficacy in COVID-19 disease is unknown. Early identification of treatment failure warranted to avoid delays endotracheal intubation and protective ventilation. We conducted a study determine the rate factors associated NIVS critically ill patients with disease, compare that matched cohort hypoxemic respiratory other origins. Methods: All consecutive receiving first-line for due ICU University Hospital Italy...
Abstract Anapnoguard endotracheal tubes and control unit were used in 15 patients with COVID-19 acute respiratory distress syndrome. system provides suction, venting, rinsing of subglottic space controls cuff pressure detecting air leakage through the cuff. Alpha-amylase pepsin levels, as oropharyngeal gastric microaspiration markers, detected from 85 tracheal aspirates.Oropharyngeal occurred 47 cases (55%). Episodes weren’t detected. There wasn’t correlation enzyme levels between prone...