A5018702403- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Bone Tumor Diagnosis and Treatments
- Cancer-related cognitive impairment studies
- Chromatin Remodeling and Cancer
- Cancer-related molecular mechanisms research
- Ocular Oncology and Treatments
- Testicular diseases and treatments
- Epigenetics and DNA Methylation
- Electrolyte and hormonal disorders
- Pharmacological Effects and Toxicity Studies
- Chemotherapy-induced organ toxicity mitigation
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Acute Myeloid Leukemia Research
- Cardiac tumors and thrombi
- Mycobacterium research and diagnosis
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Transplantation: Methods and Outcomes
Duchess of Kent Children's Hospital
2020-2023
University of Hong Kong
2022
University College London
2021
SickKids Foundation
2021
Hospital for Sick Children
2016-2021
Great Ormond Street Hospital
2021
Tuen Mun Hospital
2016-2020
Despite being the most common pediatric solid tumors, incidence and outcome of CNS tumors in Chinese children have not been systematically reported. We addressed this knowledge gap by comparing epidemiology Hong Kong United States.Data between 1999 2016 from a population-based cancer registry Kong, China, on patients < 18 years old with (Hong cohort) US SEER Program (Asian/Pacific Islander all ethnicities) were compared. Incidence overall survival (OS) histology evaluated.During study...
Abstract Objective The aim of this study was to review clinical outcomes and prognosis paediatric patients with acute lymphoblastic leukaemia (ALL) TCF3‐PBX1 rearrangement. Patients All children in Hong Kong diagnosed ALL rearrangement over the past two decades were included. Methods Six hundred twenty‐four newly from four consecutive studies enrolled 1997 2016. carrying at intermediate risk without gene expression compared for characteristics, overall survival event‐free (EFS). Results...
Childhood intracranial germ cell tumor (GCT) survivors are prone to radiotherapy-related neurotoxicity, which can lead neurocognitive dysfunctions. Diffusion kurtosis imaging (DKI) is a diffusion MRI technique that sensitive brain microstructural changes. This study aimed investigate the association between DKI metrics versus cognitive and functional outcomes of childhood GCT survivors. was performed on (n = 20) who had received cranial radiotherapy, age gender-matched healthy control...
Abstract INTRODUCTION Infantile glioblastoma is rare with poor prognosis. Recent molecular study for infantile hemispheric high grade glioma found its association ALK/ROS1/NTRK/MET pathway. This suggested the potential use of targeted therapy refractory / relapse patients. CASE: A newborn presented apnea, CT brain showed intracranial haemorrhage. MRI then a left parietal tumour bleeding and mass effect. Craniotomy achieved subtotal resection. Chemotherapy VCR/CPM alternating CDDP/VP-16 was...
We report a case series of 14 children with intracranial germ cell tumor and concomitant central diabetes insipidus, who developed hyponatremia secondary to renal salt-wasting syndrome (RSWS) following the administration carboplatin. Clinicians prescribing platinum-based chemotherapy for this group patients should be alert risk RSWS. Regular monitoring performed as can asymptomatic until it is severe.
Abstract INTRODUCTION Magnetic resonance imaging (MRI) is the gold-standard for neuroimaging, yet details from anatomical scans might be inconclusive in certain scenarios. This study aimed to investigate utility of amino-acid tracer positron emission tomography-magnetic (PET-MRI) based on a territory-wide Pediatric Neuro-Oncology cohort Hong Kong. METHODS We reviewed PET-MRI pediatric patients with suspected/confirmed CNS neoplasms co-managed by Kong Children’s Hospital and St. Teresa’s...
We present the clinical course of a 4-year-old girl with neurofibromatosis type 1-associated, unresectable, symptomatic urinary bladder ganglioneuroma. She was initially trialed on sirolimus without response and subsequently responded to MEK inhibitor trametinib, improvement clinically radiographically over 10 months. This report broadens repertoire therapeutic strategies for inhibition in diseases related MAPK pathway.
Abstract Central nervous system germ cell tumors (CNS-GCT) are malignant neoplasms that arise predominantly during adolescence and young adulthood. These typically sensitive to treatment, but resulting long-term health deficits common. Additional clinical challenges include surgical risks associated with tumor biopsy, need determine treatment response for adapting radiotherapy protocols. The aim of this study was establish the detectability circulating-tumor DNA (ctDNA) from cerebrospinal...
This paper examines the link between CNS tumor biology and heterogeneity use of genome-wide DNA methylation profiling as a clinical diagnostic platform. tumors are most common solid in children, their prognosis remains poor. study retrospectively analyzed pediatric patients with embryonal Hong Kong 1999 2017, using data from territory-wide registry available formalin-fixed paraffin-embedded tissue. After processing archival tissue via extraction, quantification, profiling, were by web-based...
Low-grade fibromyxoid sarcomas (LGFMSs) are typically adult-onset tumors that arise from the extremities. Here, we report an exceptional case of primary thoracic LGFMS in 8-year-old girl resulted mediastinal syndrome. In reporting this case, discuss clinical challenges, role molecular profiling and review reported cases pediatric LGFMSs.
This journal suppl. entitled: Abstracts from the 17th International Symposium on Pediatric Neuro-Oncology (ISPNO), June 12-15, 2016, Liverpool, United Kingdom
Abstract OBJECTIVE To review local infantile high-grade glioma (IHG) patients and their outcome. BACKGROUND Infantile is diagnosed in less than 12 months of age. Studies have shown that it displays a more stable genome, are usually single mutation driven. The most identifiable mutations receptor tyrosine kinase (RTK) fusion, such as NTRK family, ROS1, ALK MET. current principal treatment remains to be surgery, but challenging for complete resection due hemispheric involvement....
Abstract OBJECTIVES To review the clinical features, pathology and survivals of infants with brain tumours. METHODS A retrospective findings, pathology, treatment survival outcome in RESULTS From 1999 to 2018, there were 507 children (&lt;18 years) who diagnosed have tumours Hong Kong. The patients treated five public hospitals. data collected by Kong Paediatric Haematology Oncology Study Group, cross-checked Cancer Registry. In this group patients, 36 (birth 365 days age) i.e. 7.1%...
Abstract BACKGROUND Childhood intracranial germ cell tumour (iGCT) survivors are prone to radiotherapy-related neurotoxicity which can lead neurocognitive dysfunction. Diffusion kurtosis imaging (DKI) is a MRI technique that quantifies microstructural changes in the grey and white matter of brain. This study aims investigate associations between MR-DKI metrics, cognitive functional outcomes childhood iGCT survivors. METHOD 20 who had received cranial radiotherapy were recruited. DKI...
Primitive myxoid mesenchymal tumour of infancy (PMMTI) a rare and aggressive soft tissue driven by alteration in the BCOR gene. Localised disease may be cured surgical resection but metastatic often displays suboptimal chemotherapy response. Here we report course patient with widely PMMTI, where durable control was achieved combination apatinib, VEGFR inhibitor, irinotecan/temozolomide.
Abstract Here we describe the clinical course and unique molecular findings in a female neonate with infantile hemispheric glioma (IHG). The patient presented at age of 17 days macrocephaly suboptimal weight gain. MRI brain revealed an 8.5cm mass over right frontal region significant effect entrapment ventricles. Urgent ventriculoperitoneal shunt insertion biopsy highly vascular lesion was performed. Pathology compatible glioblastoma multiforme. Methylation profiling classified sample as...
Abstract A 3-month-old girl had left cerebral infantile hemispheric glioma (IHG), H3 wild type (wt), Grade IV (WHO2020) with diffuse leptomeningeal and spinal metastasis. Craniotomies were performed twice which achieved partial resection. Histopathology revealed high grade glioma, Ki67 30-40%, mitosis widespread necrosis. IHC showed H3wt, IDH-, retained INI-1. RNAseq found ETV6-NTRK3 fusion. She was treated per Baby POG-9233, however after 3 cycles, there mixed response (static for primary,...
Abstract Genome-wide DNA methylation profiling has emerged as an important diagnostic tool that complements histopathology for CNS tumors in children and adults. Literature describing its application Asian countries is nonetheless limited. Herein, we report the feasibility utility of adopting such platform diagnosed with Hong Kong. A multi-institutional cohort (n=94, 97% Chinese ethnicity) embryonal or high grade neuroepithelial (HGNET) Kong from 1996–2020 was assembled based on tissue...
Abstract The incidence of central nervous system non-germinomatous germ cell tumor (NGGCT) is four times higher in Chinese children than the Western population. Reports on outcome Asian patients are nonetheless limited. Here we aim to summarize experience treating pediatric NGGCT Hong Kong. Leveraging a population-wide oncology database, with diagnosed from 2002–2020 (n=43) were retrospectively studied. diagnoses made either elevation markers (AFP/hCG; n=19), or by histology with/without...