A5050802566- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Neural and Behavioral Psychology Studies
- Behavioral Health and Interventions
- Stress Responses and Cortisol
- Face Recognition and Perception
- Death Anxiety and Social Exclusion
- Personality Traits and Psychology
- Psychological Well-being and Life Satisfaction
- Psychosomatic Disorders and Their Treatments
- Child and Animal Learning Development
- Neuroscience, Education and Cognitive Function
- Psychological Treatments and Assessments
- Motivation and Self-Concept in Sports
- Emotional Intelligence and Performance
- Early Childhood Education and Development
- Autism Spectrum Disorder Research
- Cognitive Abilities and Testing
- Neurotransmitter Receptor Influence on Behavior
- Resilience and Mental Health
- Maternal Mental Health During Pregnancy and Postpartum
Charité - Universitätsmedizin Berlin
2015-2021
Freie Universität Berlin
2018-2021
Humboldt-Universität zu Berlin
2018-2021
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018
Background Bipolar disorder (BD), with the hallmark symptoms of elevated and depressed mood, is thought to be characterized by underlying alterations in reward-processing networks. However, date neural circuitry abnormal responses during reward processing BD remains largely unexplored. The aim this study was investigate whether euthymic aberrant ventral striatal (VS) activation patterns altered connectivity prefrontal cortex response monetary gains losses. Method During functional magnetic...
Altered connectivity of dorsolateral prefrontal cortex (DLPFC) and hippocampus during working memory is considered an intermediate phenotype for schizophrenia (SCZ), but the relevance other mental disorders with shared genetic background remains unknown. Here we investigated its presence in unaffected first-degree relatives patients bipolar disorder (BD) or major depressive (MDD). Furthermore, aimed to provide independent replication this SCZ patients. We acquired functional magnetic...
The formation of a coherent and unified self-concept represents key developmental stage during adolescence.Imaging studies on self-referential processing in adolescents are rare, it is not clear whether neural structures involved self-reflection also reflections familiar others.In the current study, 41 were asked to make judgments about trait adjectives functional magnetic resonance imaging (fMRI): they had indicate word describes themselves, their friends, teachers or politicians.Findings...
Adolescence is a critical maturation period for human cognitive control and executive function. In this study, large sample of adolescents (n = 85) performed reversal learning task during functional magnetic resonance imaging. We analyzed behavioral data using reinforcement model to provide individually fitted parameters imaging with regard reward prediction errors (PE). Following model-based approach, we formed two groups depending on whether individuals tended update expectations...
As evidenced by a multitude of studies, abnormalities in Theory Mind (ToM) and its neural processing might constitute an intermediate phenotype schizophrenia. If so, alterations during ToM should be observable unaffected relatives patients as well, since they share considerable amount genetic risk. While behaviorally, impaired function is confirmed meta-analytically relatives, evidence on aberrant the network sparse inconclusive. The present study therefore aimed to further explore...
Students' sense of belonging presents an essential resource for academic and health outcomes, whereas social exclusion at school negatively impacts students' well-being performance. Aiming to understand how feelings school-related shape the structural brain development, this study applied longitudinal questionnaire-based data MRI from 71 adolescent students (37 females, Mage t1 = 15.0; t2 16.1 years). All were white participants Germany. Voxel-based morphometry revealed only association (and...
Objectives Behavioral deficits in the Theory of Mind (ToM) have been robustly demonstrated bipolar disorder. These may represent an intermediate phenotype disease. The aim this study was: (i) to investigate alterations neural ToM processing euthymic patients with disorder, and (ii) examine whether similar effects are present unaffected relatives disorder suggesting that functional activation be, part, due genetic risk for Methods A total 24 21 first‐degree relatives, 81 healthy controls...
The amygdala is essential for processing emotions, including the of aversive faces. aim this multimethodological study was to relate reactivity students (N = 88) toward teachers' fearful and angry faces, students' relationship with their teachers. Furthermore, neural responses during perception faces were tested as predictors test anxiety (controlling neuroticism a potential trait effect). Multiple regression analysis revealed that reporting high-quality teacher-student relationships showed...
The present interdisciplinary study explored whether perceived loneliness is associated with ventromedial prefrontal cortex (vMPFC) activation during self- and social judgments (friends teachers) in adolescents. Moreover, we examined how vMPFC activity related to the academic self-concept (ASC). Results of manifest path analysis indicated that high was lower neural response self-judgments. In turn, self-judgments positively ASC, whereas there a trendwise negative association between...
This multi-methodological study applied functional magnetic resonance imaging (fMRI) to investigate neural activation in a group of adolescent students (N = 88) during probabilistic reinforcement learning task. We related patterns emerging brain activity and individual rates socio-motivational (in-)dependence manifested four different motivation types (MT): (1) peer-dependent MT, (2) teacher-dependent (3) peer-and-teacher-dependent (4) peer-and-teacher-independent MT. A multinomial...
Abstract Mid-adolescence is a critical time for the development of stress-related disorders and it associated with significant social vulnerability. However, little known about normative neural processes accompanying psychosocial stress at this time. Previous research found that emotion regulation strategies critically influence relationship between psychiatric symptoms during adolescence. Using functional magnetic resonance imaging (fMRI), we examined responses to acute analyzed whether...
Following the relational-developmental systems approach, this three-wave study examines whether acute stress (T2) mediates relationship between development of personality traits from beginning 8th grade (T1, M age = 15.63, SD 0.59; 22 girls) to end 9th (T3). Using Montréal Imaging Stress Task, which is a task that provokes social by negative feedback, combined functional magnetic resonance imaging (fMRI), heart rate, and longitudinal survey data 41 adolescents. Mediation analysis revealed...
Abstract The level of functioning individuals with autism spectrum disorder (ASD) varies widely. To better understand the neurobiological mechanism associated high-functioning ASD, we studied rare case a female patient an exceptional professional career in highly competitive academic field Mathematics. According to Research Domain Criteria (RDoC) approach, which proposes describe basic dimensions by integrating different levels information, conducted four fMRI experiments targeting (1)...