Ling Zhu

ORCID: 0000-0003-0950-5905
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About
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Research Areas
  • Respiratory viral infections research
  • Hepatitis B Virus Studies
  • Phytochemicals and Antioxidant Activities
  • Hepatitis C virus research
  • Viral gastroenteritis research and epidemiology
  • Advanced Proteomics Techniques and Applications
  • Machine Learning in Bioinformatics
  • Bioinformatics and Genomic Networks
  • Natural Antidiabetic Agents Studies
  • Phytochemistry and biological activity of medicinal plants
  • Treatment of Major Depression
  • Toxoplasma gondii Research Studies
  • Insect Resistance and Genetics
  • Immunotherapy and Immune Responses
  • Chromatography in Natural Products
  • Auditing, Earnings Management, Governance
  • CRISPR and Genetic Engineering
  • Mental Health Research Topics
  • Berberine and alkaloids research
  • Immune Response and Inflammation
  • Essential Oils and Antimicrobial Activity
  • Traditional Chinese Medicine Analysis
  • Cynara cardunculus studies
  • Stock Market Forecasting Methods
  • Herpesvirus Infections and Treatments

Huazhong University of Science and Technology
2022

Syngenta (United States)
2021

Triangle
2021

Inner Mongolia Medical University
2020

Institute of Biophysics
2020

Chinese Academy of Sciences
2020

Bristol-Myers Squibb (United States)
2014

Otsuka (United States)
2014

Wuhan University
2012-2013

Recent advances in the development of CRISPR-Cas genome editing technologies have made it possible to perform targeted mutagenesis and precise gene replacement crop plants. CRISPR-Cas9 CRISPR-Cas12a are two main types widely used systems. However, when machinery is expressed from a transgene, some chromosomal targets encountered low frequency important crops like maize soybean. Here, we report efficient methods directly generate edited lines by delivering Cas12a-gRNA ribonucleoprotein...

10.3389/fgeed.2021.670529 article EN cc-by Frontiers in Genome Editing 2021-05-12

AbstractAbstractThe authors investigate the effects and mechanisms of anti-hepatitis B virus (HBV) agent Bay 41-4109. HepG2.2.15 cells were used to antiviral 41-4109 by using real-time polymerase chain reaction (PCR), western blotting, immunofluorescence. The C terminally truncated core protein was ex-pressed purified. Changes in hepatitis capsid formation assayed dynamic light scattering transmission electronic microscopy. found be a highly selective potent inhibitor replication cells. This...

10.1179/joc.2008.20.4.458 article EN Journal of Chemotherapy 2008-08-01

This study evaluated the relationship between patient characteristics and augmentation strategies for treatment of major depressive disorder.This retrospective, cross-sectional used data from a psychiatric electronic medical record database patients with depression without psychosis or psychotic features who initiated therapy January 2001 June 2011. Medical records were to identify factors predicting use specific agents, multivariate logistic regression model was assess clinical demographic...

10.1176/appi.ps.201300288 article EN Psychiatric Services 2014-06-16

Abstract Motivation Data mining and data quality evaluation are indispensable constituents of quantitative proteomics, but few integrated tools available. Results We introduced obaDIA, a one-step pipeline to generate visualizable comprehensive results for proteomics data. obaDIA supports fragment-level, peptide-level protein-level abundance matrices from DIA technique, as well other proteomic techniques. The result contains matrix statistics, differential expression analysis, protein...

10.1093/bioinformatics/btaa893 article EN Bioinformatics 2020-10-02

Objective To investigate the impact of diet, way parenting and living environment on recurrent upper respiratory tract infections (rURTIs) in children, to discuss risk protective factors order explore new method for taking prevention measures. Methods From December 2008 May 2009, a total 230 children aged 3 6 years old who were admitted Department Child Health Care, Children Hospital Shanxi, including 151 boys (65.7%) 79 girls (34.3%). Among those 118 diagnosed as (case group)...

10.3877/cma.j.issn.1673-5250.2010.01.105 article EN Chung-Hua Fu Ch'an K'o Tsa Chih 2010-02-01

Abstract Motivation Data mining and data quality evaluation are indispensable constituents of quantitative proteomics, but few integrated tools available. Results We introduced obaDIA, a one-step pipeline to generate visualizable comprehensive results for proteomics data. obaDIA supports fragment-level, peptide-level protein-level abundance matrices from DIA technique, as well other proteomic techniques. The result contains matrix statistics, differential expression analysis, protein...

10.1101/2020.05.28.121020 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2020-05-31
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